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Establishment of a new disease concept "the kidney and lung correlation through RAS in a renal damage"

Research Project

Project/Area Number 22590886
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionNagoya University

Principal Investigator

SATO Waichi  名古屋大学, 医学部附属病院, 講師 (90508920)

Co-Investigator(Kenkyū-buntansha) YUZAWA Yukio  藤田保健衛生大学, 医学部 (00191479)
MARUYAMA Shoichi  名古屋大学, 医学部附属病院, 講師 (10362253)
Co-Investigator(Renkei-kenkyūsha) KADOMATSU Kenji  名古屋大学, 大学院・医学系研究科, 教授 (80204519)
NISHIYAMA Akira  香川大学, 医学部, 教授 (10325334)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsミッドカイン / 急性腎障害(AKI) / 慢性腎臓病(CKD) / RAS / 急性腎障害(AKI) / 慢性腎臓病(CKD) / renin-angiotensin-system (RAS)
Research Abstract

The outcome to this research task was as follows. In the CKD model (5/6 nephrectomy), MK expression increased in a lung. In vitro,the amount of production of MK decreased by transfection of MK-siRNA into endothelial cells. Although the mouse was made to breathe in this siRNA, MK expression did not decrease. In another CKD model (L-NAME administration +Uninephrectomy), blood pressure did notelevated in MK deficient mice. there was no difference of ACE expression in serum or a lung between wild type mice and MK defficent mice. In the AKI model (bilateral IRI model and bilateral uninephrectomy), the change on neutrophil infiltration and edema was obserbed inthe lung. In the low oxygen exposure experiment which used the renal tubular cells, intracellular MK expression did not increase but the amount of production of MK in serum increased temporally. In the new ARDS/ALI patients, , mortality rate in the non-AKI group increased significantly rather than the AKI group as the long period of time of respirator management.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (90 results)

All 2013 2012 2011 2010 Other

All Journal Article (27 results) (of which Peer Reviewed: 21 results) Presentation (61 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats.2013

    • Author(s)
      Katsuno T
    • Journal Title

      Cell Transplant

      Volume: 22(2) Issue: 2 Pages: 287-97

    • DOI

      10.3727/096368912x655019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KDIGO (Kidney Disease: Improving Global Outcomes) criteria could be a useful outcome predictor of cisplatin-induced acute kidney injury2012

    • Author(s)
      Mizuno T, Sato W, Ishikawa K, Shinjo H, Miyagawa Y, Noda Y, Imai E, Yamada K
    • Journal Title

      Oncology

      Volume: 82(6) Pages: 354-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Midkine and the kidney: health and diseases2012

    • Author(s)
      Kosugi T, Sato W
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27(1) Pages: 16-21

    • Related Report
      2012 Final Research Report
  • [Journal Article] Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy.2012

    • Author(s)
      Tanabe K
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 303(9)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KDIGO (Kidney Disease: Improving Global Outcomes) criteria could be a useful outcome predictor of cisplatin-induced acute kidney injury.2012

    • Author(s)
      Mizuno T
    • Journal Title

      Oncology.

      Volume: 82(6) Issue: 6 Pages: 354-9

    • DOI

      10.1159/000338664

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Midkine and the kidney: health and diseases.2012

    • Author(s)
      Kosugi T
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 27(1) Issue: 1 Pages: 16-21

    • DOI

      10.1093/ndt/gfr652

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 3 ligand, polyIC, induces proteinuria and glomerular CD80, and increases urinary CD80 in mice.2012

    • Author(s)
      Ishimoto T
    • Journal Title

      Nephrol Dial Transplant.

      Volume: inpress

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis.2012

    • Author(s)
      Kojima H
    • Journal Title

      Am J Pathol.

      Volume: 182(2) Pages: 410-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy.2012

    • Author(s)
      Hirayama A
    • Journal Title

      Anal Bioanal Chem.

      Volume: 404(10) Issue: 10 Pages: 3101-9

    • DOI

      10.1007/s00216-012-6412-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of hydrogen sulfide (H(2)S)-producing enzymes and the roles of the H(2)S donor sodium hydrosulfide in diabetic nephropathy.2012

    • Author(s)
      Yamamoto J
    • Journal Title

      Clin Exp Nephrol.

      Volume: 17(1) Issue: 1 Pages: 32-40

    • DOI

      10.1007/s10157-012-0670-y

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete remission within 2 years predicts a good prognosis after methylprednisolone pulse therapy in patients with IgA nephropathy2012

    • Author(s)
      Tatematsu M
    • Journal Title

      Clin Exp Nephrol

      Volume: 16(6) Issue: 6 Pages: 883-91

    • DOI

      10.1007/s10157-012-0644-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin.2012

    • Author(s)
      Ito I
    • Journal Title

      Clin Exp Nephrol

      Volume: 16(3) Issue: 3 Pages: 490-4

    • DOI

      10.1007/s10157-012-0620-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective stimulation of VEGFR2 accelerates progressive renal disease2011

    • Author(s)
      Sato W, Tanabe K, Kosugi T, Hudkins K, Lanaspa MA, Zhang L, Campbell-Thompson M, Li Q, Long DA, Alpers CE, Nakagawa T
    • Journal Title

      Am J Pathol

      Volume: 179(1) Pages: 155-66

    • Related Report
      2012 Final Research Report
  • [Journal Article] Kato K, Kosugi T, Sato W, Tsuboi N, Tawada H, Matsuo S, Kadomatsu K, Maruyama S. (他4 名,3 番目)2011

    • Author(s)
      Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(3) Pages: 346-54

    • Related Report
      2012 Final Research Report
  • [Journal Article] Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis2011

    • Author(s)
      Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S
    • Journal Title

      Nephrol.Dial.Tranplant.

      Volume: 27(6) Issue: 6 Pages: 2511-6

    • DOI

      10.1093/ndt/gfr685

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin2011

    • Author(s)
      Kato K
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(3) Pages: 346-54

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of Fulminant Peritonitis Caused by Streptococcus mitis in a Patient on Peritoneal Dialysis2011

    • Author(s)
      Mizuno M
    • Journal Title

      Intern Med

      Volume: 50(16) Pages: 1719-23

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction2011

    • Author(s)
      Kato N
    • Journal Title

      Am J Pathol

      Volume: 178(2) Pages: 572-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production2011

    • Author(s)
      Saka Y
    • Journal Title

      Am J Pathol

      Volume: 178(2) Pages: 572-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Stimulation of VEGFR2 Accelerates Progressive Renal Disease2011

    • Author(s)
      Sato W
    • Journal Title

      Am J Pathol

      Volume: 179(1) Pages: 155-66

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis2011

    • Author(s)
      Suzuki Y
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(6) Pages: 962-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis2011

    • Author(s)
      Toda S
    • Journal Title

      Nephrol Dial Transplant

      Volume: (inpress)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Midkine and the kidney : health and diseases2011

    • Author(s)
      Kosugi T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27(1) Pages: 16-21

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney2010

    • Author(s)
      Nakayama T, Sato W, Yoshimura A, Kosugi T, Kojima H, Croker BP, Nakagawa T.
    • Journal Title

      Am J Pathol

      Volume: 176(5) Pages: 2198-208

    • Related Report
      2012 Final Research Report
  • [Journal Article] Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia.2010

    • Author(s)
      湯澤由紀夫
    • Journal Title

      Internal Medicine

      Volume: 49 Pages: 1139-42

    • NAID

      130000251642

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney.2010

    • Author(s)
      Nakayama T
    • Journal Title

      Ameircan journal of Pathology

      Volume: 176 Pages: 2198-208

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy

    • Author(s)
      Tanabe K, Tamura Y, Sato W, Nakagawa T.
    • Journal Title

      Am J Physiol Renal Physiol

    • Related Report
      2012 Final Research Report
  • [Presentation] 臓器連関障害を救済するための急性血液浄化療法の位置付け2012

    • Author(s)
      湯沢由紀夫
    • Organizer
      第23回日本急性血液浄化学会学術集会
    • Place of Presentation
      パステルホテル大宮
    • Year and Date
      2012-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 血液透析患者にお,けるアディポカインと心血管死の関連2012

    • Author(s)
      佐藤和一
    • Organizer
      第57回日本透析医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2012-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノチューブを介したオルガネラ交換-幹細胞治療の新たなメカニズム2012

    • Author(s)
      安田香
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 集中治療患者において、急性腎障害の診断基準である KDIGO 分類と AKIN 分類の比較2012

    • Author(s)
      新城響
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 成長因子ミッドカインの欠損は、半月体形成性腎炎の進展を促進する2012

    • Author(s)
      小島博
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 高血圧・内皮障害におけるミッドカインの役割2012

    • Author(s)
      佐藤由香
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of Diverticular Diseases by Computed Tomography Is Useful for Selection of Peritoneal Dialysis Modality and Asymptomatic Diverticulosis Is Not a Risk Factor for Peritonitis2011

    • Author(s)
      Yasuhiko Ito
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Growth Factor Midkine Ameliorates Crescentic Glomerulonephritis through Inhibiting Thrombosis2011

    • Author(s)
      Hiroshi Kojima
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Comparison of the Acute Kidney Injury Network and Kidney Disease : Improving Global Outcomes Criteria for Acute Kidney Injury in Critically Ill Patients2011

    • Author(s)
      Hibiki Shinjo
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lymphangiogenesis Develops during Peritoneal Fibrosis in Peritoneal Dialysis Patients and Rat Peritonitis Model2011

    • Author(s)
      Hiroshi Kinashi
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Distribution of Hydrogen Sulfide (H2S)-Producing Enzymes and the Roles of H2S in Diabetic Nephropathy2011

    • Author(s)
      Jun-ichiro Yamamoto
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Low Serum Cultured Adipose-Derived Mesenchymal Stem Cells, but Not Bone-Marrow Derived Mesenchymal Stem Cells, Ameliorate Rat Crescentic Glomerulonephritis by Functional Polarization of Macrophages into Immunoregulatory Phenotype2011

    • Author(s)
      Kazuhiro Furuhashi
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prognostic Value of Geriatric Nutritional Risk Index for Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients on Chronic Hemodialysis2011

    • Author(s)
      Kaoru Yasuda
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association of Adipokines with Cardiovascular Mortality in Patients on Hemodialysis2011

    • Author(s)
      Shoichi Maruyama
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Pivotal Role of Midkine on the Development of Hypertension in Endothelial Dysfunction2011

    • Author(s)
      Yuka Sato
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Low Serum Cultured Adipose Derived Stem Cells Ameliorate Zymosan Induced Severe Rat Peritonitis Model2011

    • Author(s)
      Hangsoo Kim
    • Organizer
      ASN
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性腎臓病患者におけるHMG-COA還元酵素阻害薬(ピタバスタチン)の腎機能に及ぼす影響の検討(P-STAR-CKD)2011

    • Author(s)
      安田宜成
    • Organizer
      第41回日本腎臓学会西部学術総会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性腎臓病患者におけるHMG-CoA還元酵素阻害薬(ピタバスタチン)の腎機能に及ぼす影響の検討(P-STAR-CKD)2011

    • Author(s)
      安田宜成
    • Organizer
      第41回日本腎臓学会西部学術総会
    • Place of Presentation
      徳島(徳島県郷土文化会館)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 組織学的に診断された重度腎孟腎炎合併移植腎の1症例2011

    • Author(s)
      伊藤裕紀子
    • Organizer
      第41回日本腎臓学会西部学術総会
    • Place of Presentation
      徳島(徳島県郷土文化会館)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糸球体病変を欠くANCA関連腎炎の2症例2011

    • Author(s)
      野中慶佑
    • Organizer
      第41回日本腎臓学会西部学術総会
    • Place of Presentation
      徳島(徳島県郷土文化会館)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂肪由来間葉系幹細胞を用いた壊死性半月体形成腎炎への新たな治療法の確立~骨髄由来間葉系細胞にはなく塩脂肪由来幹細胞がもつ Macrophage への unique chaqracter~2011

    • Author(s)
      古橋和拡
    • Organizer
      第三回腎疾患と高血圧研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 脂肪由来間葉系幹細胞を用いた壊死性半月体形成腎炎への新たな治療法の確立~骨髄由来間葉系細胞にはなく塩脂肪由来幹細胞がもつMacrophageへのunique chaqracter~2011

    • Author(s)
      古橋和拡
    • Organizer
      第三回腎疾患と高血圧研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多肢趾壊死を伴ったコレステロール塞栓症による腎不全に対して腹膜透析を選択した一例2011

    • Author(s)
      早崎貴洋
    • Organizer
      第56回日本透析医学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 異物によるS状結腸穿孔から汎発性腹膜炎をきたしたCAPD患者の一例2011

    • Author(s)
      中島諒子
    • Organizer
      第56回日本透析医学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腹膜透析における小、中、大分子量物質除法と腹膜機能の関連性2011

    • Author(s)
      平松英樹
    • Organizer
      第56回日本透析医学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Oxaliplatinにより自己免疫性溶血性貧血・血小板減少を伴うAKIを来した1例2011

    • Author(s)
      伊藤功
    • Organizer
      第56回日本透析医学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 疣贅PCEによりStaphylococcus warneriを起因菌と同定できた感染性心内膜炎の1例2011

    • Author(s)
      伊藤功
    • Organizer
      第56回日本透析医学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Therapeutic Potential of Adipose-Derived Stem Cells for Anti-GBM Glomerulonephritis2010

    • Author(s)
      古橋和拡
    • Organizer
      42rd Annual Meeting of The American Society of Nephrology
    • Place of Presentation
      Colorado Convention Center Denver, CO
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Knock-Down of HGF and VEGF Production Reduces the Renoprotective Effects of Adipose-Derived Stromal Cells in the Acute Kidney Injury2010

    • Author(s)
      勝野敬之
    • Organizer
      42rd Annual Meeting of The American Society of Nephrology
    • Place of Presentation
      Colorado Convention Center Denver, CO
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Basigin/CD147 Promotes Renal Fibrosis after Unilateral Ureteral Obstruction2010

    • Author(s)
      Noritoshi Kato
    • Organizer
      42rd Annual Meeting of The American Society of Nephrology
    • Place of Presentation
      Colorado Convention Center Denver, CO
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lymphangiogenesis Develops during Tubulo-Interstitial Fibrosis Via the TGF-b-VEGF-C Pathway in Rat Unilateral Ureteral Obstruction2010

    • Author(s)
      鈴木康弘
    • Organizer
      42rd Annual Meeting of The American Society of Nephrology
    • Place of Presentation
      Colorado Convention Center Denver, CO
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Peritoneal Macrophage Infiltration Is Correlated with Baseline Peritoneal Solute Transport Rate in Peritoneal Dialysis Patients2010

    • Author(s)
      澤井晶穂
    • Organizer
      42rd Annual Meeting of The American Society of Nephrology
    • Place of Presentation
      Colorado Convention Center Denver, CO
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Tuener 症候群と馬蹄腎の患者に合併した抗基底膜抗体型腎炎の一例2010

    • Author(s)
      佐藤和一
    • Organizer
      第40回日本腎臓学会東部学術大会
    • Place of Presentation
      広島
    • Year and Date
      2010-10-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Tuener症候群と馬蹄腎の患者に合併した抗基底膜抗体型腎炎の一例2010

    • Author(s)
      佐藤和一
    • Organizer
      第40回日本腎臓学会西部学術大会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] リツキシマブが有効であったクリオグロブリン血症の一例2010

    • Author(s)
      早崎貴洋
    • Organizer
      第40回日本腎臓学会西部学術大会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] VEGF receptor2 特異的結合性VEGF-A の強発現は腎障害を引き起こす2010

    • Author(s)
      小杉智規
    • Organizer
      第40回日本腎臓学会東部学術大会
    • Place of Presentation
      広島
    • Year and Date
      2010-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] VEGF receptor2特異的結合性VEGF-Aの強発現は腎障害を引き起こす2010

    • Author(s)
      小杉智規
    • Organizer
      第40回日本腎臓学会西部学術大会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] クリオグロブリン血症を伴いゲムシタビン誘発TMAをきたした一例2010

    • Author(s)
      立松美穂
    • Organizer
      第40回日本腎臓学会西部学術大会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎再生療法における低血清培養脂肪組織由来間葉系細胞の有用性2010

    • Author(s)
      勝野敬之
    • Organizer
      第31回日本炎症・再生学会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Therapeutic potential of adipose-derived stem cells for anti-GBM glomerulonephritis2010

    • Author(s)
      古橋和拡
    • Organizer
      7th International Conference on Innate Immunity
    • Place of Presentation
      ギリシャ
    • Year and Date
      2010-07-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 原因同定困難な腹膜炎の一例2010

    • Author(s)
      戸田晋
    • Organizer
      第55回日本透析医学会学術集会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急速な病勢増悪を認めたα streptococcusによるCAPD腹膜炎の一例2010

    • Author(s)
      増田智広
    • Organizer
      第55回日本透析医学会学術集会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] AKIの新規バイオマーカー2010

    • Author(s)
      湯澤由紀夫
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場・神戸ポートピアホテル・神戸国際展示場
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性透析患者におけるCD34陽性細胞数の減少は心血管予後不良予測因子である~4年間の前向きコホート研究~2010

    • Author(s)
      丸山彰一
    • Organizer
      第55回日本透析医学会学術集会
    • Place of Presentation
      神戸商工会議所会館
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 超音波造影剤を用いた腎血流と腎機能との関連の検討2010

    • Author(s)
      尾崎武徳
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場・神戸ポートピアホテル・神戸国際展示場
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪由来間葉系幹細胞によるGoodpastue diseaseモデルへの治療効果の検討2010

    • Author(s)
      古橋和拡
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場・神戸ポートピアホテル・神戸国際展示場
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺腎連関/midkine2010

    • Author(s)
      湯沢由紀夫
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場・神戸ポートピアホテル・神戸国際展示場
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adipose-derived stem cellS therapy iS effective in the treatment of anti-GBM glomerulonephritis.2010

    • Author(s)
      古橋和拡
    • Organizer
      APCN 2010
    • Place of Presentation
      Convention and Exhibition Center (COEX), Seoul, Korea
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] RENOPROTECTIVE EFFECTS AND MECHANISMS OF HUMAN ADIPOSE TISSUE-DERIVED S TROMALCELLS CULTURED IN LOW SERUM MEDIA ON ACUTE KIDNEY INJURY2010

    • Author(s)
      勝野敬之
    • Organizer
      APCN 2010
    • Place of Presentation
      Convention and Exhibition Center (COEX), Seoul, Korea
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adipose-derived mesenchymal stem cells suppress antibody production against graft antigens2010

    • Author(s)
      阪洋祐
    • Organizer
      ISN nexus
    • Place of Presentation
      京都国際会議センター(ICC京都府)
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Renoprotective effects of human adiposetissue-derived stromal cells cultured in low serum media on acute kidney injury2010

    • Author(s)
      勝野敬之
    • Organizer
      ISN nexus
    • Place of Presentation
      京都国際会議センター(ICC京都府)
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adipose-derived stem cells therapy is effective in the treatment of anti-GBM glomerulonephritis2010

    • Author(s)
      古橋和拡
    • Organizer
      ISN nexus
    • Place of Presentation
      京都国際会議センター(ICC京都府)
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Reduced number of circulating CD34-positivecells is associated with poor cardiovascular outcomes in chronic hemodialysis patients2010

    • Author(s)
      丸山彰一
    • Organizer
      ISN nexus
    • Place of Presentation
      京都国際会議センター(ICC京都府)
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Malnutrition and chonic inflammation status at initiating phase of hemodialysis can stratify the risk of cardiovascular and all-cause moetality in CKD stage5 patients-10-year follow-up study2010

    • Author(s)
      Ryo Takahashi
    • Organizer
      ISN nexus
    • Place of Presentation
      京都国際会議センター(ICC京都府)
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lymphangiogenesis develop during tubulo-interstitial fibrosis in rat unilateralureteral obstruction via TGF-B-VEGF-C pathway2010

    • Author(s)
      鈴木康弘
    • Organizer
      ISN nexus
    • Place of Presentation
      京都国際会議センター(ICC京都府)
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎再生療法における低血清培養脂肪組織由来間葉系細胞の有用性2010

    • Author(s)
      勝野敬之
    • Organizer
      第31回日本炎症・再生学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臓器連関障害を救済するための急性血液浄化療法の位置付け

    • Author(s)
      湯沢由紀夫
    • Organizer
      第23回日本急性血液浄化学会学術集会
    • Place of Presentation
      パステルホテル大宮(埼玉)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血液透析患者にお,けるアディポカインと心血管死の関連

    • Author(s)
      佐藤和一
    • Organizer
      第57回日本透析医学会学術集会
    • Place of Presentation
      さっぽろ芸術文化の館(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノチューブを介したオルガネラ交換-幹細胞治療の新たなメカニズム

    • Author(s)
      安田香
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 集中治療患者において、急性腎障害の診断基準であるKDIGO分類とAKIN分類の比較

    • Author(s)
      新城響
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 成長因子ミッドカインの欠損は、半月体形成性腎炎の進展を促進する

    • Author(s)
      小島博
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 腎疾患のバイオマーカー及びその用途2012

    • Inventor(s)
      小杉智規、丸山彰一、佐藤和一、門松健治
    • Industrial Property Rights Holder
      名古屋大学
    • Acquisition Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 糖尿病性腎症鑑別用マーカー及びその用途2012

    • Inventor(s)
      丸山彰一、湯澤由紀夫、松尾清一、佐藤和一、尾崎武徳、秋山真一、曽我朋義、平山明由
    • Industrial Property Rights Holder
      名古屋大学
    • Acquisition Date
      2012-09-14
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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