Impairment of neurovasculaer unit under chronic hypoperfusion

• Project/Area Number: 22590929
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Mie University
• Principal Investigator: YATA Kenichiro 三重大学, 大学院・医学系研究科, 産学官連携研究員 (40467361)
• Co-Investigator(Kenkyū-buntansha): TOMIMOTO Hidekazu 三重大学, 大学院・医学系研究科, 教授 (80324648)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 神経分子病態学 / small vessel disease / chronic cerebral hypoperfuion / Two-photon microscopy / capillary plugging / rolling and adhesion / 脳小血管病 / 慢性脳低灌流 / 二光子レーザー顕微 / 血管内皮細胞 / 脳血液関門 / 二光子レーザー顕微鏡 / 白血球 / Rolling / Adhesion / 血液脳関門

Research Abstract

To understand the role of chronic cerebral hypoperfusion in cerebral small vessel disease, repeated longitudinal in vivo imaging was performed by using two-photon microscopy. Under chronic hypoperfuion, leukocyte plugging in deep capillary and leukocyte rolling and adhesion in pial vessel were detected.

Research Products

• [Journal Article] Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the PSEN1 gene (2013)
  • Author(s): Niwa A, MatsuoK, Shindo A, Yata K,Tomimoto H.
  • Journal Title: Neuropathology Volume: 33 Pages: 199-203
  • Peer Reviewed
• [Journal Article] Clinical and neuropathological findings in a patient with familial Alzheimer disease showing a mutation in the PSEN1 gene. (2013)
  • Author(s): Niwa A
  • Journal Title: Neuropathology Volume: 33 Issue: 2 Pages: 199-203
  • DOI: 10.1111/j.1440-1789.2012.01340.x
  • Peer Reviewed
• [Journal Article] Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion. (2011)
  • Author(s): Dong YF, Kataoka K, Toyama K, Sueta D, Koibuchi N, Yamamoto E, Yata K, Tomimoto H, Ogawa H, Kim-Mitsuyama S
  • Journal Title: Hypertension. Volume: 58 Pages: 635-42
  • Peer Reviewed
• [Presentation] Chronic cerebral hypoperfusion and dementia (2013)
  • Author(s): 矢田健一郎
  • Organizer: 日本神経学会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Invited
• [Presentation] 光子励起レーザー顕微鏡を用いたマウス慢性脳低灌流状態における微小循環動態の評価 (2012)
  • Author(s): 矢田健一郎
  • Organizer: 第37回 日本脳卒中学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-27
• [Presentation] 2光子励起レーザー顕微鏡を用いた頭動脈閉塞症の微小循環動態のreal time観察 (2011)
  • Author(s): 矢田健一郎
  • Organizer: 第52回日本神経学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] 2光子励起レーザー顕微鏡を用いた頸動脈閉塞症の微小循環動態のreal time観察 (2011)
  • Author(s): 矢田健一郎
  • Organizer: 第52回日本神経学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-18
• [Presentation] 光子励起レーザー顕微鏡を用いたマウス頚動脈狭窄性病変モデルにおける血行動態の評価 (2011)
  • Author(s): 矢田健一郎
  • Organizer: 第36回日本脳卒中学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-25
• [Presentation] 2光子励起レーザー顕微鏡を用いたマウス脳低灌流状態における血行動態の評価 (2010)
  • Author(s): 矢田健一郎
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-20