Impairment of neurovasculaer unit under chronic hypoperfusion
| Project/Area Number |
22590929
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Mie University |
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Principal Investigator |
YATA Kenichiro 三重大学, 大学院・医学系研究科, 産学官連携研究員 (40467361)
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| Co-Investigator(Kenkyū-buntansha) |
TOMIMOTO Hidekazu 三重大学, 大学院・医学系研究科, 教授 (80324648)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経分子病態学 / small vessel disease / chronic cerebral hypoperfuion / Two-photon microscopy / capillary plugging / rolling and adhesion / 脳小血管病 / 慢性脳低灌流 / 二光子レーザー顕微 / 血管内皮細胞 / 脳血液関門 / 二光子レーザー顕微鏡 / 白血球 / Rolling / Adhesion / 血液脳関門 |
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| Research Abstract |
To understand the role of chronic cerebral hypoperfusion in cerebral small vessel disease, repeated longitudinal in vivo imaging was performed by using two-photon microscopy. Under chronic hypoperfuion, leukocyte plugging in deep capillary and leukocyte rolling and adhesion in pial vessel were detected.
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Report
(4 results)
Research Products
(9 results)
