Towards gene therapy for m i tochondrial disease: delivery anc expression exogenous DNA in mitochondria.

• Project/Area Number: 22590949
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyushu University (2012); National Center of Neurology and Psychiatry (2010-2011)
• Principal Investigator: MATSUSHIMA Yuichi 九州大学, 医学研究院, 助教 (20571342)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ミトコンドリア病 / 遺伝子治療

Research Abstract

The method for mitochondrial transgene expression in animal cells has not been established and this method might be applicable to the gene therapy for mitochondrial diseases, which are mainly caused by mitochondrial DNA mutations. For successful mitochond

Research Products

• [Journal Article] Matrix proteases in mitochondria DNA function (2012)
  • Author(s): Yuichi Matsushima, Laurie Kaguni
  • Journal Title: Biochemica et Biophysica Acta Volume: 819 Issue: 9-10 Pages: 1080-1087
  • DOI: 10.1016/j.bbagrm.2011.11.008
  • Peer Reviewed
• [Journal Article] Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A(TFAM) (2010)
  • Author(s): 松島雄一
  • Journal Title: Proceedings of National Academy of Sciences of the United States of America Volume: 107 Pages: 18410-18415
  • Peer Reviewed
• [Presentation] Protein Turnover in Regulation of Mitochondrial DNA Copy Number and Gene Expression. (2011)
  • Author(s): Yuichi Matsushima
  • Organizer: Euromit8
  • Place of Presentation: AUDITORIO - PALACIO DECONGRESOSサラゴサ(スペイン)
• [Presentation] Mitochondrial Lonprotease regulates mitochondrial DNA copynumber and transcription (2011)
  • Author(s): Yuichi Matsushima
  • Organizer: 第5回アジアフリーラジカル学会・第8回アジア&第11回日本ミトコンドリア学会合同大会
  • Place of Presentation: 鹿児島市民文化ホール(鹿児島県)
• [Presentation] Protein Turnover in Regulation of Mitochondrial DNA Copy Number and Gene Expression. (2011)
  • Author(s): 松島雄一
  • Organizer: Euromit8
  • Place of Presentation: AUDITORIO - PALACIO DE CONGRESOS サラゴサ（スペイン）
• [Presentation] Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription. (2011)
  • Author(s): 松島雄一
  • Organizer: 第5回アジアフリーラジカル学会・第8回アジア＆第１１回日本ミトコンドリア学会合同大会
  • Place of Presentation: 鹿児島市民文化ホール (鹿児島県)
• [Presentation] Mitochondrial Lon protease regulates mitochondiial DNA copy number and transcription by selective degradation of TFAM (2010)
  • Author(s): 松島雄一
  • Organizer: 第32回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-08
• [Presentation] Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of TFAM (2010)
  • Author(s): 松島雄一
  • Organizer: Gordon Research Conference-Mitochondria & Chloroplast
  • Place of Presentation: Il Ciocco Hotel and Resort, Lucca(イタリア)
  • Year and Date: 2010-07-12
• [Presentation] Mitochondrial Lon protease regulates mitochondrial DNAcopy number and transcription by selective degradation of TFAM (2010)
  • Author(s): Yuichi Matsushima
  • Organizer: 第32回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)