Hepatic and vascular insulin resistance in PI3kinase p85αdeficientmice
| Project/Area Number |
22590990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Yokohama City University |
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Principal Investigator |
AOKI Kazutaka 横浜市立大学, 医学部, 助教 (60336542)
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| Co-Investigator(Kenkyū-buntansha) |
TERAUCHI Yasuo 横浜市立大学, 医学研究科, 教授 (40359609)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | PI3キナーゼp85α / 肝臓インスリン感受性 / 糖尿病 / 肝臓 / 血管 / インスリン抵抗性 / PI3キナーゼ |
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| Research Abstract |
Phosphoinositide 3-kinase (PI3K) p85alpha-deficient mice exhibit hypoglycemia as a result of increased insulin sensitivity and glucose uptake in peripheral tissues. We previouslyinvestigated hepatic glucose homeostasis in p85alpha-deficient and wild-type mice. Gluconeogenesis was rather elevated in p85alpha-deficient mice, compared with in wild-type mice. In this study, we evaluated the hepatic glucose production of primary hepatocyte in p85alpha-deficient and wild-type mice. Hepatic glucose production of primary hepatocyte in p85alpha-deficient mice was not decreased compared to that in wild type mice.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Trefoil Factor 2 Promotes Cell Proliferation in Pancreatic β-Cells through CXCR-4-Mediated ERK1/2 Phosphorylation2013
Author(s)
Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y
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Journal Title
Endocrinology
Volume: 154(1)
Pages: 54-64
Related Report
Peer Reviewed
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[Journal Article] Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice2011
Author(s)
Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K,Aoki K, Morimoto C, Takeda E, Terauchi Y
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Journal Title
Diabetes
Volume: 60(4)
Pages: 1246-57
Related Report
Peer Reviewed
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[Journal Article] Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet2011
Author(s)
Muraoka T, Aoki K, Iwasaki T, Shinoda K, Nakamura A, Aburatani H, Mori S, Tokuyama K, Kubota N, Kadowaki T, Terauchi Y.
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Journal Title
Metabolism
Volume: 60(5)
Pages: 617-628
NAID
Related Report
Peer Reviewed
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[Journal Article] Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet.2011
Author(s)
Muraoka T, Aoki K, Iwasaki T, Shinoda K, Nakamura A, Aburatani H, Mori S, Tokuyama K, Kubota N, Kadowaki T, Terauchi Y.
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Journal Title
Metabolism
Volume: 60
Pages: 617-628
NAID
Related Report
Peer Reviewed
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[Journal Article] Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice.2011
Author(s)
Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y.
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Journal Title
Diabetes
Volume: 60
Pages: 1246-1257
Related Report
Peer Reviewed
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[Journal Article] Self-Injection of Insulin Using Appropriate Supportive Devices in Handicapped Subjects with Diabetes.2010
Author(s)
Masuda K, Aoki K, Kikuchi K, Nezu U, Muraoka T, Shinoda K, Nakamura A, Shibuya M, Takahashi M, Kimura M, Terauchi Y
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Journal Title
Diabetes Technol Ther
Volume: 12(6)
Pages: 483-490
Related Report
Peer Reviewed
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[Journal Article] Pravastatin potentiates increases in serum adiponectin concentration in dyslipidemic patients receiving thiazolidinedione: the DOLPHIN study2010
Author(s)
Nezu U, Tsunoda S, Yoshimura H, Kuwabara T, Tomura S, Seki Y, Kaneshiro M, Kamiyama H, Harada Y, Shigematsu E, Aoki K, Yamakawa T, Ohshige K, Natsumeda Y, Terauchi Y
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Journal Title
J Atheroscler Thromb
Volume: 17(10)
Pages: 1063-1069
NAID
Related Report
Peer Reviewed
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[Journal Article] Problems in diagnosing atypical Gitelman's syndrome presenting with normomagnesaemia2010
Author(s)
Nakamura A, Shimizu C, Nagai S, Yoshida M, Aoki K, Kondo T,Miyoshi H, Wada N, Tajima T, Terauchi Y,Yoshioka N, Koike T
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Journal Title
Clin Endocrinol (Oxf)
Volume: 72(2)
Pages: 272-276
Related Report
Peer Reviewed
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