| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Phosphoinositide 3-kinase (PI3K) p85alpha-deficient mice exhibit hypoglycemia as a result of increased insulin sensitivity and glucose uptake in peripheral tissues. We previouslyinvestigated hepatic glucose homeostasis in p85alpha-deficient and wild-type mice. Gluconeogenesis was rather elevated in p85alpha-deficient mice, compared with in wild-type mice. In this study, we evaluated the hepatic glucose production of primary hepatocyte in p85alpha-deficient and wild-type mice. Hepatic glucose production of primary hepatocyte in p85alpha-deficient mice was not decreased compared to that in wild type mice.
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