Exploratory research for the development of genetic markers in dyslipidemia using genome bank with data of visceral obesity.

• Project/Area Number: 22591001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Jichi Medical University
• Principal Investigator: IWAMOTO Sadahiko 自治医科大学, 医学部, 教授 (10232711)
• Co-Investigator(Kenkyū-buntansha): GOTOH Takaya 自治医科大学, 医学部, 講師 (80284355) ; NAKAYAMA Kazuhiro 自治医科大学, 医学部, 助教 (90433581) ; MIYASHITA Hiroshi 自治医科大学, 医学部, 准教授 (90301449)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脂質代謝異常 / 脂質異常症 / メタボリック症候群 / 遺伝子多型 / 遺伝子環境相互作用 / TRIB1 / TRIB2

Research Abstract

A genome resource bank is established through this study project, which includes 3000 Japanese sample combined with clinical, visceral adiposity and life style data. Several genetic markers associated with dyslipidemia and obesity were identified by the g

Research Products

• [Journal Article] Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia. (2013)
  • Author(s): Nakayama K, Ogawa A, Miyashita H, Tabara Y, Igase M, Kohara K, Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S
  • Journal Title: Hum Genet Volume: 132 Issue: 2 Pages: 201-217
  • DOI: 10.1007/s00439-012-1240-9
  • Peer Reviewed
• [Journal Article] Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue (2012)
  • Author(s): Rosell M, Hondares E, Iwamoto S, Gonzalez FJ, Wabitsch M, Staels B, Olmos Y, Monsalve M, Giralt M, Iglesias R, Villarroya F.
  • Journal Title: Endocrinology Volume: 153(3) Issue: 3 Pages: 1162-73
  • DOI: 10.1210/en.2011-1367
  • Peer Reviewed
• [Journal Article] High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia (2011)
  • Author(s): Nakayama K, Yanagiswa Y, Ogawa A, Ishizuka Y, Munkhtulga L, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Koda Y, Ishida T, Kagawa Y, Iwamoto S
  • Journal Title: J Hum Genet Volume: 56 Issue: 12 Pages: 828-833
  • DOI: 10.1038/jhg.2011.109
  • NAID: 10030661852
  • Peer Reviewed
• [Journal Article] Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity (2011)
  • Author(s): NagashimaS, Yagyu H, Takahashi N, Kurashina T, Takahashi M, Tsuchita T, Tazoe F, Wang XL, Bayasgalan T, Sato N, Okada K, Nagasaka S, Gotoh T, Kojima M, Hyodo M, Horie H, Hosoya Y, Okada M, Yasuda Y, Fujiwara H, Ohwada M, IwamotoS, Suzuki M, Nagai H, Ishib
  • Journal Title: J Atheroscler Thromb Volume: 18(3) Pages: 190-9
  • NAID: 130004444498
  • URL: https://www.jstage.jst.go.jp/article/jat/18/3/18_6478/_article
• [Journal Article] Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues (2011)
  • Author(s): Nagashima S, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 18 Issue: 3 Pages: 190-199
  • DOI: 10.5551/jat.6478
  • NAID: 130004444498
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Depot-specific expression of lipolytic genes in human adipose tissues. (2011)
  • Author(s): Nagashima S
  • Journal Title: J Atheroscler Thromb Volume: 18 Pages: 190-199
  • Peer Reviewed
• [Journal Article] JichiMedical University Promotion Team of a Large-scale Human Genome Bank for All over Japan. A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive (2010)
  • Author(s): NakayamaK, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, IwamotoS
  • Journal Title: Hum Genet Volume: 127(6) Issue: 6 Pages: 685-90
  • DOI: 10.1007/s00439-010-0815-6
• [Journal Article] Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI. (2010)
  • Author(s): Munkhtulga L, Nagashima S, NakayamaK, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Zolzaya K, Lkhagvasuren T, Kagawa Y, Fujiwara H, Hosoya Y, Hyodo M, Horie H, Kojima M, Ishibashi S, IwamotoS.
  • Journal Title: Obesity (Silver Spring). Volume: 18(5) Issue: 5 Pages: 1006-14
  • DOI: 10.1038/oby.2009.358
• [Journal Article] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. (2010)
  • Author(s): Nakayama K
  • Journal Title: Human Genetics Volume: 127 Pages: 685-690
  • Peer Reviewed
• [Journal Article] Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI. (2010)
  • Author(s): Munkhtulga L
  • Journal Title: Obesity (Silver Spring) Volume: 18 Pages: 1006-1014
  • Peer Reviewed
• [Presentation] TRIB1 is involved in the susceptibility of non-alcoholic fatty liver disease (2012)
  • Author(s): Iwamoto S, Ishizuka Y, Kitamura Y, Makishima S, Boonvisut S, Nakayama K
  • Organizer: 62nd Annual Meeting of American Society of Human Genetics
  • Place of Presentation: San Francisco
  • Year and Date: 2012-11-09
• [Presentation] 血清脂質関連Trib1多型は脂肪肝とも関連する (2012)
  • Author(s): 岩本禎彦、石塚裕美、北村愉介、巻嶋咲穂、Supichaya Boonvisut、中山一大、宮下 洋
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-27
• [Presentation] 腹部インピダンス法で測定した内臓脂肪面積のゲノム解析への応用 (2012)
  • Author(s): 中山一大、柳沢佳子、恩田智彦、片嶋充弘、岡田浩一、福島省吾、宮下洋、岩本禎彦
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-25
• [Presentation] 血清脂質レベル関連遺伝子Trib1の肝臓発現の摂食関連概日リズムによる調節 (2012)
  • Author(s): 石塚裕美、Supichaya Boonvisut、北村愉介、巻嶋咲穂、中山一大、岩本禎彦
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-12
• [Presentation] 内臓脂肪測定ゲノムバンクの構築と候補遺伝子との関連SNP解析 (2012)
  • Author(s): 岩本禎彦、石塚裕美、中山一大、巻嶋咲穂、北村愉介、Supichaya Boonvisut、宮下洋、柳沢佳子、片島充弘、恩田智彦、福島省吾、岡田浩一
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-11
• [Presentation] 腹部インピーダンス法で測定した内臓脂肪面積のゲノム解析への応用 (2012)
  • Author(s): 中山一大
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
• [Presentation] TRIB1 is involved in the susceptibility of non-alcoholic fatty liver disease. (2012)
  • Author(s): Iwamoto S
  • Organizer: Annual Meeting of American Society of Human Genetics
  • Place of Presentation: San Francisco
• [Presentation] Mixed genome を用いた血清脂質関連遺伝子のリシークエンス (2011)
  • Author(s): 岩本禎彦、石塚裕美,小川歩美,中山一大
  • Organizer: 日本人類遺伝学回第56回大会
  • Place of Presentation: 千葉県千葉市
  • Year and Date: 2011-11-12
• [Presentation] Tribbles homolog2遺伝子は東アジア人の中心性肥満と関連する (2011)
  • Author(s): 中山一大,小川歩美,石塚裕美,柳沢佳子,宮下洋,香川靖雄,岩本禎彦
  • Organizer: 日本人類遺伝学回第56回大会
  • Place of Presentation: 千葉県千葉市
  • Year and Date: 2011-11-11
• [Presentation] Tribbles homolog2遺伝子は東アジア人の中心性肥満と関連する (2011)
  • Author(s): 中山一大, 他6名
  • Organizer: 日本人類遺伝学会第56回大会
  • Place of Presentation: 千葉市
  • Year and Date: 2011-11-11
• [Presentation] Mixed genomeを用いた血清脂質関連遺伝子のリシークエンス (2011)
  • Author(s): 岩本禎彦, 他6名
  • Organizer: 日本人類遺伝学会第56回大会
  • Place of Presentation: 千葉市
  • Year and Date: 2011-11-11
• [Presentation] 血清脂質レベル関連遺伝子Trib1導入マウスにおけるエネルギー消費 (2011)
  • Author(s): 石塚裕美,小川歩美,中山一大,岩本禎彦
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 兵庫県淡路市
  • Year and Date: 2011-09-23
• [Presentation] 新規血清脂質レベル関連遺伝子Trib1導入マウス肝臓のトランスクリプトーム解析 (2011)
  • Author(s): 岩本禎彦、石塚裕美,小川歩美,中山一大
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 兵庫県淡路市
  • Year and Date: 2011-09-23
• [Presentation] 新規血清脂質レベル関連遺伝子Trib1導入マウスにおけるエネルギー消費 (2011)
  • Author(s): 石塚裕美, 他3名
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路市
  • Year and Date: 2011-09-23
• [Presentation] 新規血清脂質レベル関連遺伝子Trib1導入マウス肝臓のトランスクリプトーム解析 (2011)
  • Author(s): 岩本禎彦, 他3名
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路市
  • Year and Date: 2011-09-23
• [Presentation] OPCML is a schizophrenia-susceptible gene in Thai population. (2011)
  • Author(s): Panichareon B, Nakayama K, Thurakitwannakarn W, Iwamoto S, SukhumsirichartW
  • Organizer: The 34the Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2011-09-17
• [Presentation] Common variant of the TRIB2influences central obesity. (2011)
  • Author(s): Nakayama K, Ogawa A, Ishizuka Y, Yanagisawa Y, Miyashita H, Kagawa Y, Iwamoto S
  • Organizer: 12the International Congress of Human Genetics/61th Annual Meeting of American Society of Human Genetics
  • Place of Presentation: Montreal, Canada
• [Presentation] TRIB2と中心性肥満:倹約遺伝子仮説の観点から. (2011)
  • Author(s): 中山一大、小川歩美、石塚裕美、柳沢佳子、宮下洋、香川靖雄、岩本禎彦
  • Organizer: 第65回日本人類学会大会
  • Place of Presentation: 沖縄県那覇市
• [Presentation] Association study of polymorphisms in CTXN3 gene with schizophrenia in Thai population. (2010)
  • Author(s): Benjaporn Panichareon
  • Organizer: 日本DNA多型学会
  • Place of Presentation: 三島市
  • Year and Date: 2010-11-18
• [Presentation] 高脂血症感受性遺伝子TRIB1は高血圧とも関連する (2010)
  • Author(s): 石塚裕美
  • Organizer: 日本DNA多型学会
  • Place of Presentation: 三島市
  • Year and Date: 2010-11-18
• [Presentation] アジア・太平洋地域の人類集団におけるスカベンジャー受容体ファミリーの遺伝的多様性 (2010)
  • Author(s): 中山一大
  • Organizer: 日本人類遺伝学会
  • Place of Presentation: さいたま市
  • Year and Date: 2010-10-28
• [Presentation] 糖感受性エレメントのTRIB1遺伝子脂質異常症関連領域へのマッピングと遺伝子機能解析 (2010)
  • Author(s): 岩本禎彦
  • Organizer: 日本遺伝子診療学会
  • Place of Presentation: 津市
  • Year and Date: 2010-08-06
• [Presentation] Resequencing of human type B scavenger receptor genes in Asia-Pacific populations. (2010)
  • Author(s): Nakayama K, Ogawa A, Yanagisawa Y, Gotoh T, Miyashita H, Munkhtulga L, Kagawa Y, Iwamoto S
  • Organizer: The American Society of Human Genetics 60thannual meeting
  • Place of Presentation: Washington, DC
• [Presentation] 糖感受性エレメントのTRIB1 遺伝子脂質異常症関連領域へのマッピングと遺伝子機能解析 (2010)
  • Author(s): 岩本禎彦、石塚裕美、小川歩美、後藤孝也、中山一大
  • Organizer: 第17回日本遺伝子診療学会
  • Place of Presentation: 三重
• [Presentation] アジア・オセアニアにおけるスカベンジャー受容体ファミリー遺伝子の多様性 (2010)
  • Author(s): 中山一大,小川歩美,柳沢佳子,後藤孝也,宮下洋,神田芳郎,ムンフトルガ・ルハグワスレン,香川靖雄,岩本禎彦
  • Organizer: 第64回日本人類学会大会
  • Place of Presentation: 伊達市
• [Presentation] Association study of polymorphisms in CTXN3gene with schizophrenia in Thai population (2010)
  • Author(s): Panichareon B, Nakayama K, Sukhumsirichart W, Thurakitwannakarn W, Kagawa Y, IwamotoS
  • Organizer: DNA多型学会第19回学術集会
  • Place of Presentation: 三島市
• [Presentation] 高脂血症感受性遺伝子TRIB1 は高血圧とも関連する (2010)
  • Author(s): 石塚裕美、中山一大、小川歩美、柳沢佳子、後藤孝也、宮本洋、岩本禎彦
  • Organizer: DNA 多型学会第19回学術集会
  • Place of Presentation: 三島市