Elucidation of molecular mechanism of T cell differentiation inhibiting factor GIF on regulation of adipose tissue remodeling

Research Project

Project/Area Number	22591011
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Endocrinology
Research Institution	Tokyo Medical and Dental University
Principal Investigator	SAIJO Misa 東京医科歯科大学, 大学院・医歯学総合研究科, 特任助教 (10566813)
Co-Investigator(Renkei-kenkyūsha)	SUGANAMI Takayoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (50343752)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	GIF / T 細胞 Interleukin-4 / 獲得免疫 / 肥満 / インスリン抵抗性 / 耐糖能 / T 細胞 / IL-4 / リンパ球 / CD4T細胞 / サイトカイン / Th2化 / 脂肪細胞
Research Abstract	Our data of this study suggest that Glycosylation Inhibiting Factor (GIF), secretes from CD4 T cells in obese adipose tissue, inhibits interleukin (IL-4) secretion from CD4 T cells in adipose tissue, resulting in worsening of both glucose tolerance and insulin sensitivity. This data concludes that GIF have a significant role in balancing and regulating adipose tissue remodeling.

Report

(4 results)