Elucidation of molecular mechanism of T cell differentiation inhibiting factor GIF on regulation of adipose tissue remodeling
| Project/Area Number |
22591011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SAIJO Misa 東京医科歯科大学, 大学院・医歯学総合研究科, 特任助教 (10566813)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGANAMI Takayoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (50343752)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | GIF / T 細胞 Interleukin-4 / 獲得免疫 / 肥満 / インスリン抵抗性 / 耐糖能 / T 細胞 / IL-4 / リンパ球 / CD4T細胞 / サイトカイン / Th2化 / 脂肪細胞 |
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| Research Abstract |
Our data of this study suggest that Glycosylation Inhibiting Factor (GIF), secretes from CD4 T cells in obese adipose tissue, inhibits interleukin (IL-4) secretion from CD4 T cells in adipose tissue, resulting in worsening of both glucose tolerance and insulin sensitivity. This data concludes that GIF have a significant role in balancing and regulating adipose tissue remodeling.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Increased expression of macrophage- inducible C-type lectin in adipose tissue of obese mice and humans2011
Author(s)
Ichioka M, Suganami T, Tsuda N, Shirakawa I, Hirata Y, Satoh-Asahara N,Shimoda Y, Tanaka M , Kim-Saijo M Miyamoto Y, Kamei Y, Sata M, Ogawa Y
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Journal Title
Diabetes
Volume: 60
Pages: 819-26
Related Report
Peer Reviewed
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