Novel pathologic factors in vasculitis - comprehensive analysis by peptidomics and their clinical significance
| Project/Area Number |
22591087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
OZAKI Shoichi 聖マリアンナ医科大学, 医学部, 教授 (00231233)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Tomohiro 聖マリアンナ医科大学, 医学部, 教授 (80233807)
KUROKAWA Manae 聖マリアンナ医科大学, 医学部, 准教授 (90301598)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ANCA 関連血管炎 / 前向き臨床試験 / 病態関連ペプチド / プロテオミクス / アポリポ蛋白 A-1 / ANCA関連血管炎 / アポリポ蛋白A-1 |
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| Research Abstract |
Peptidomic analysis revealed 7 peptides that significantly increased or decreased in sera of patients with microscopic polyangiitis (MPA) before treatment. Among them, a peptide of 1523 kDa was identified as a C-terminal 13-mer peptide of apolipoprotein A-I, hence named AC13. AC13 was found to increase only in sera of patients with active MPA and decrease after treatment. AC13 stimulated endothelial cell lines to secrete significant levels of IL-6 and IL-8. Thus, AC13 seemed to play a pathological role in MPA and serve as a novel biomarker.
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Report
(4 results)
Research Products
(174 results)
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[Journal Article] Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis.2013
Author(s)
Sato T., Yamano Y., Tomaru U., Shimizu Y., Ando H., Okazaki T., Nagafuchi H., Shimizu J., Ozaki S., Miyazawa T., Yudoh K., Oka H., Suzuki N.
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Journal Title
Mod Rheumatol
Volume: in press
DOI
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[Journal Article] Severity-based treatment for Japanese patients with MPO-ANCA-associated vasculitis: the JMAAV study.2012
Author(s)
Ozaki S., Atsumi T., Hayashi T., Ishizu A., Kobayashi S., Kumagai S., Kurihara Y., Kurokawa MS, Makino H., Nagafuchi H., Nakabayashi K., Nishimoto N., Yumura W.
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Journal Title
Mod Rheumatol.
Volume: 22(3)
Pages: 394-404
Related Report
Peer Reviewed
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[Journal Article] Cutaneous polyarteritis nodosa associated with HLA-B39-positive undifferentiated spondyloarthritis in a Japanese patient.2012
Author(s)
Nakano H., Ooka S., Shibata T., Ogawa H., Ito H., Takakuwa Y., Tonooka K., Maeda A., Yamasaki Y., Kiyokawa T., Nagafuchi H., Yamada H. and Ozaki S
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Journal Title
Mod Rheumatol.
Volume: 22(5)
Pages: 783-786
Related Report
Peer Reviewed
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[Journal Article] Anti-high mobility group box 1 and box 2 non-histone chromosomal proteins (HMGB1/HMGB2) antibodies and anti-Saccharomyces cerevisiae antibodies (ASCA): accuracy in differentially diagnosing UC and CD and correlation with inflammatory bowel disease phenotype.2012
Author(s)
Takaishi H., Kanai T., Nakazawa A., Sugata F., Nikai A., Yoshizawa S., Hamamoto Y., Funakoshi S., Yajima T., Iwao Y., Takemura M., Ozaki S., Hibi T.
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Journal Title
J Gastroenterol
Volume: 47
Pages: 969-977
Related Report
Peer Reviewed
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[Presentation] Comprehensive analysis of protein expression in peripheral blood mononuclear cells from patients with Behcet’s disease.2012
Author(s)
Yoshioka T., Kurokawa M., Takakuwa Y., Nakano H., Ooka S., Iizuka N., Sato T., Arito M., Nagai K. Okamto K., Suematsu N., Suzuki N., Ozaki S., Kato T.:
Organizer
American College of Rheumatology 2012.
Place of Presentation
Washington. U.S.A.
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