| Project/Area Number |
22591107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
EISHI Yoshinobu 東京医科歯科大学, 医学部, 教授 (70151959)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 自然免疫 / NOD family / サルコイドーシス / クローン病 / Nod Like Receptors / NOD2 / サイコイドーシス / 免疫学 / 感染症 / 細菌 / 遺伝子 / NOD like receptors |
|---|
| Research Abstract |
In order to apply to the medical treatment of Crohn's disease or sarcoidosis, the mutant of low NOD family of a background was produced. Moreover, the dominant negative mutantwas produced and the application to the medical treatment of Blau syndrome was aimed at. Apoptosis induction ability of the NOD family active control agent was clarified. As a cause of sarcoidosis, the abnormalities in balance of Th-1 and Th-17 by the immune response insufficiency to P. acne were clarified. The abnormalities of NOD2 of the differentiation stage from blood stem cell to myeloid cell showed clearly that it relates to development of symptoms of leukemia.
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