| Project/Area Number |
22591112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOSHINO Ichiro 東京女子医科大学, 医学部, 助教 (80328377)
MANNO Sumie 東京女子医科大学, 医学部, 講師 (10101205)
TANAKA Shotaro 東京女子医科大学, 医学部, 助教 (90380667)
ARASHIKI Nobuto 東京女子医科大学, 医学部, 助教 (80569658)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 脂質ラフト / リドカイン / Plasmodium falciparum / Feline immunodeficiency virus / 抗感染症薬 / 感染症 / シグナル伝達 / G蛋白質共役受容体 |
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| Research Abstract |
Plasmodium falciparum, a causative agent of malaria, and feline immunodeficiency virus were used as models for parasitic and viral infection, respectively. Lidocaine treatment disrupted lipid rafts in respective host cells and concomitantly inhibited the parasite invasion and viral entry. Detailed study revealed that malaria parasites activateraft-mediated signal transduction in host erythrocytes to phosphorylate dematin, a membrane skeletal protein. Phosphorylation of dematin results in a transient loosening of membrane skeletal meshwork, allowing the parasite invasion. Lidocain was shown to inhibit the parasite invasion by preventing membrane skeletal loosening via disruption of lipid rafts
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