Brap gene can be one of causal genes of the Ras-MAPK syndromes.

• Project/Area Number: 22591141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nippon Medical School
• Principal Investigator: ASADA Minoru 日本医科大学, 医学部, 講師 (60366755)
• Co-Investigator(Renkei-kenkyūsha): MIZUTANI Shuki 東京医科歯科大学, 医歯学総合研究科, 教授 (60126175) ; IKEDA Yumiko 日本医科大学, 医学部, 助教 (10386154)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 遺伝 / 先天異常学 / 遺伝子改変マウス / brap / Ras / MAPK / 遺伝子ターゲッティング / 胎生致死 / Ras-MAPK / Brap2 / NCFC症候群 / brap2 / Ras-MAPK経路 / NCFC症侯群

Research Abstract

To elucidate the biological significance of BRAP gene, brap targeting mice were generated. Brap null mice revealed embryonic lethal, which indicates Brap has essential role for developmental process. Whether Brap could be involved in Ras-MAPK pathway, mouse embryonic fibroblasts from brap mutant mice were analyzed. Phosphorylation of ERK was upregulated in brap deficient cells.

Research Products

• [Journal Article] Corticosterone facilitates fluoxetine-induced neuronal plasticity in the hippocampus (2013)
  • Author(s): Kobayashi K, Ikeda Y, Asada M, Inagaki H, Kawada T, Suzuki H.
  • Journal Title: PLoS ONE Volume: 8(5)
  • Peer Reviewed
• [Journal Article] Autoimmune Lymphoproliferative Syndrome Like Disease With Somatic (2011)
  • Author(s): Takagi M, Shinoda K, Piao J, Mitsuiki N,Takagi M, Matsuda K, Muramatsu H,Doisaki S, Nagasawa M, Morio T,Kasahara Y, Koike K, Kojima S, Takao A,Mizutani S
  • Journal Title: KRAS Mutation.Blood Volume: 117 Pages: 2887-90
  • Peer Reviewed
• [Journal Article] Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells (2011)
  • Author(s): Atsumi Y, Fujimori H, Fukuda H, Inase A, Shinohe K, Yoshioka Y, Shikanai M, Ichijima Y, Unno J, Mizutani S, Tsuchiya N, Hippo Y, Nakagama H, Masutani M, Teraoka H, Yoshioka K.
  • Journal Title: PLoS One Volume: 6(8)
  • Peer Reviewed
• [Journal Article] Autoimmune phenomena in Noonan syndrome; a possible link with (2010)
  • Author(s): Mizutani S, Takagi M.
  • Journal Title: RALD. Blood. e-letter
  • Peer Reviewed
• [Journal Article] Cerebral activation associated with speech sound discrimination during the diotic listening task (2010)
  • Author(s): Ikeda Y, Yahata N, Takahashi H, Koeda M, Asai K, Okubo Y, Suzuki H.
  • Journal Title: An fMRI study Neurosci. Res Volume: 67(1) Pages: 65-71
  • Peer Reviewed
• [Journal Article] Reversal of hippocampal neuronal maturation by serotonergic antidepressants (2010)
  • Author(s): Kobayashi K, Ikeda Y, Sakai A, Yamasaki N, Haneda E, Miyakawa T, Suzuki H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107(18) Pages: 8434-8439
  • Peer Reviewed
• [Journal Article] Immunologically silent cancer clone transmission from mother to offspring (2009)
  • Author(s): Isoda T, Ford A, Tomizawa D, van Delft F, De Castro DG, Mitsuiki N, Score J, Taki T, Takagi M, Morio T, Saji H, Greaves M, Mizutani S
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 106(42) Pages: 17882-5
  • Peer Reviewed
• [Journal Article] Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation. (2009)
  • Author(s): Honda M, Takagi M, Chessa L, Morio T, Mizuatni S.
  • Journal Title: Leukemia. Volume: 23 Pages: 409-14