Molecular mechanisms of peripheral blood stem cell mobilization through Interleukin-8 and its clinical application
| Project/Area Number |
22591164
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
OKAMOTO Yasuhiro 鹿児島大学, 医学部・歯学部附属病院, 講師 (30398002)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWANO Yoshifumi 鹿児島大学, 医歯学総合研究科, 教授 (20260680)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | G-CSF / 血管内皮細胞 / IL-8 / TLR / endothelial cell / mobilization / 動員 / 好中球 / インターロイキン-8 / 幹細胞 / 血管内皮 |
|---|
| Research Abstract |
Several genes were elucidated by the expression pattern when HUVEC was co-cultured with G-CSF stimulated neutrophils. Moreover, mRNA was confirmed by real time PCR and surface expression was confirmed by FACS. Within several genes, antibody to TLR2 or inhibitory peptide of TLR2 signaling decreased the IL-8 production in HUVEC as low as 35 to 50 %.
|
Report
(4 results)
Research Products
(25 results)
-
-
[Journal Article] Benzene Metabolite, 1,2,4-Benzenetriol, Induces Halogenated DNA and Tyrosines Representing Halogenative Stress in Human Myeloid Cell Line HL-602012
Author(s)
Nishikawa T, Miyahara E, Horiuchi M, Izumo K, Okamoto Y, Kawai Y, Kawano Y, Takeuchi T
-
Journal Title
Environ Health Perspect
Volume: 120
Issue: 1
Pages: 62-67
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
