| Project/Area Number |
22591233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Fujita Health University |
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Principal Investigator |
YAGAMI Akiko 藤田保健衛生大学, 医学部, 准教授 (90367699)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Hirohisa 独立行政法人国立成育医療研究センター, 副所長 (40130166)
MATSUNAGA Kayoko 藤田保健衛生大学, 医学部, 教授 (80131192)
HAYASHI Nobuhiro 東京工業大学, 生命理工学部, 准教授 (80267955)
OBOKI Keisuke 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 研究員 (80415108)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 診断バイオマーカー / 染毛剤 / para-phenylenediamine / アレルギー性接触皮膚炎 / 遺伝子解析 / p-Phenylenediamine / 毛根組織サンプル / マイクロアレイ解析 |
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| Research Abstract |
Six patients with allergic contact dermatitis due to para-phenylenediamine were studied. With the consent from these patients, blood, hair root tissue and buccal mucosa samples were taken to extract total RNA using reagents such as RNA stabilizer (RNAlaterR). Microarray and Proteomic analyses, which were conducted finally, found no significant difference from control group, and specific biomarker was not identified. However, we believe this study meaningful in that above mentioned methods were tried, for the first time, to detect biomarker of allergic contact dermatitis due to hair dye.
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