• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Induction of TSLP by environmental and self factors associated with atopic dermatitis

Research Project

Project/Area Number 22591251
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionJuntendo University

Principal Investigator

TAKAI Toshiro  順天堂大学, 大学院・医学研究科, 准教授 (70338375)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords皮膚炎症 / 再生医学 / アトピー性皮膚炎 / アレルギー / ケラチノサイト / TSLP / 経路 / 黄色ブドウ球菌 / フラジェリン / TLR
Research Abstract

We analyzed induction of TSLP in human primary keratinocytes. Staphylococcus aurous, which is known to colonize in skin of atopic dermatitis patients, bacterial flagellin, and atopic cytokine milieu, induced TSLP. We found that detection of the long form TSLP gene expression was a sensitive assay. The study identified some novel environmental and self-factors that contribute to the TSLP induction and regulation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (87 results)

All 2013 2012 2011 2010 Other

All Journal Article (45 results) (of which Peer Reviewed: 22 results) Presentation (34 results) (of which Invited: 5 results) Book (5 results) Remarks (3 results)

  • [Journal Article] Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes2013

    • Author(s)
      Chen X, Takai T, Xie Y, Francois Niyonsaba. Okumura K. Ogawa H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 433 Pages: 532-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013

    • Author(s)
      Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T
    • Journal Title

      J Immunol

      Volume: 190 Pages: 4489-99

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunization of rabbits with nematode Ascaris lumbricoides antigens induces antibodies cross-reactive to house dust mite Dermatophagoides farinae antigens2013

    • Author(s)
      Nakazawa T, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K
    • Journal Title

      Biosc Biotechnol Biochem

      Volume: 77 Pages: 145-150

    • NAID

      10031164704

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ダニアレルゲンによる経皮感作のメカニズム2013

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギー・免疫

      Volume: 20 Pages: 854-860

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes2013

    • Author(s)
      Xue Chen
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 433 Issue: 4 Pages: 532-537

    • DOI

      10.1016/j.bbrc.2013.03.024

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013

    • Author(s)
      Seiji Kamijo
    • Journal Title

      J Immunol

      Volume: 190 Issue: 9 Pages: 4489-4499

    • DOI

      10.4049/jimmunol.1201212

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes2012

    • Author(s)
      Xie Y, Takai T, Chen X, Okumura K, Ogawa H
    • Journal Title

      J Dermatol Sci

      Volume: 66 Pages: 233-237

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin E synthesis2012

    • Author(s)
      Saeki M, Nishimura T, Kaminuma O, Suzuki K, Takai T, Mori A, Takada K, Takaiwa F, Hiroi T.
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 158 Pages: 66-69

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TSLP expression: cellular sources,triggers, and regulatory mechanisms2012

    • Author(s)
      Takai T
    • Journal Title

      Allergol Int

      Volume: 61 Pages: 3-17

    • NAID

      130004873040

    • Related Report
      2012 Final Research Report
  • [Journal Article] Extracellular double-stranded RNA induces TSLP via an endosomal acidification- and NF-kB-dependent pathway in human keratinocytes2012

    • Author(s)
      Vu AT, Chen X, Xie Y, Kamijo S, Ushio H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 2205-2212

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルゲンの3つの顔2012

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギー

      Volume: 61 Pages: 930-940

    • NAID

      110009489266

    • Related Report
      2012 Final Research Report
  • [Journal Article] 私は思う:アレルゲンとは何か2012

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギーの臨床

      Volume: 32 Pages: 739-741

    • Related Report
      2012 Final Research Report
  • [Journal Article] ダニアレルギーとアレルゲン2012

    • Author(s)
      高井敏朗、池田志斈
    • Journal Title

      週刊日本医事新報

      Volume: 4582号 Pages: 57-59

    • Related Report
      2012 Final Research Report
  • [Journal Article] Th2アジュバントとしての環境アレルゲンと黄色ブドウ菌:経皮的Th2感作におけるバリア破壊と自然免疫応答2012

    • Author(s)
      高井敏朗
    • Journal Title

      日本皮膚アレルギー・接触皮膚炎学会雑誌

      Volume: 6 Pages: 8-13

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] アレルゲンの持つアジュバント作用と抗原感作機構2012

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギー・免疫

      Volume: 19 Pages: 12-19

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] アレルゲンの3つの顔2012

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギー

      Volume: 61 Pages: 930-940

    • NAID

      110009489266

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 私は思う:アレルゲンとは何か2012

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギーの臨床

      Volume: 32 Pages: 739-741

    • Related Report
      2012 Annual Research Report
  • [Journal Article] TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms2012

    • Author(s)
      Toshiro Takai
    • Journal Title

      Allergology International

      Volume: 61 Issue: 1 Pages: 3-17

    • DOI

      10.2332/allergolint.11-RAI-0395

    • NAID

      130004873040

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ダニアレルギーとアレルゲン2012

    • Author(s)
      高井敏朗
    • Journal Title

      日本医事新報

      Volume: 4582号 Pages: 57-59

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Viral infection induces thymic stromal lymphopoietin (TSLP) in human keratinocyte2011

    • Author(s)
      Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S
    • Journal Title

      J Dermatol Sci

      Volume: 62 Pages: 131-134

    • NAID

      10030891266

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases2011

    • Author(s)
      Takai T, Ikeda S
    • Journal Title

      Allergol Int

      Volume: 60 Pages: 25-35

    • NAID

      10031143296

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via Toll-like receptor 52011

    • Author(s)
      Le TA, Takai T, Vu AT, Kinoshita H, Chen X, Ikeda S, Ogawa H, Okumura K
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155 Pages: 31-37

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Missions of protease allergens in the epithelium2011

    • Author(s)
      Takai T
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 154 Pages: 3-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression2011

    • Author(s)
      Suzuki K, Kaminuma O, Yang L, Takai T, Mori A, Umezu-Goto M, Ohtomo T, Ohmachi Y, Noda Y, Hirose S, Okumura K, Ogawa H, Takada K, Hirasawa M, Hiroi T, Takaiwa F
    • Journal Title

      Plant Biotechnol J

      Volume: 9 Pages: 982-990

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルゲンはなぜアレルゲンになるのか2011

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギー

      Volume: 60 Pages: 809-816

    • Related Report
      2012 Final Research Report
  • [Journal Article] 表皮ケラチノサイトにおけるTSLP 産生誘導2011

    • Author(s)
      高井敏朗
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 55 Pages: 365-370

    • NAID

      40018789102

    • Related Report
      2012 Final Research Report
  • [Journal Article] Extracellular double-stranded RNA induces TSLP via an endosomal acidification-and NF-κB-dependent pathway in human keratinocytes2011

    • Author(s)
      Anh Tuan Vu, et al
    • Journal Title

      J Invest Dermatol

      Volume: 131 Issue: 11 Pages: 2205-2212

    • DOI

      10.1038/jid.2011.185

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral infection induces Thymic stromal lymphopoietin (TSLP) in human keratinocyte2011

    • Author(s)
      Junko Kawasaki, et al
    • Journal Title

      J Dermatol Sci

      Volume: 62 Issue: 2 Pages: 131-134

    • DOI

      10.1016/j.jdermsci.2011.02.005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen : induction of allergen-specific oral tolerance without bystander suppression2011

    • Author(s)
      Suzuki, K, et al
    • Journal Title

      Plant Biotech.J.

      Volume: 9 Issue: 9 Pages: 982-990

    • DOI

      10.1111/j.1467-7652.2011.00613.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 表皮ケラチノサイトにおけるTSLP産生誘導2011

    • Author(s)
      高井敏朗
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 55 Pages: 365-370

    • NAID

      40018789102

    • Related Report
      2011 Annual Research Report
  • [Journal Article] アレルゲンはなぜアレルゲンになるのか2011

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギー(日本アレルギー学会誌)

      Volume: 60 Pages: 809-816

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes via the Toll-like receptor 2-Toll-like receptor 6 pathway2010

    • Author(s)
      Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T
    • Journal Title

      J Allergy Clin Immunol

      Volume: 126

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction2010

    • Author(s)
      Hirasawa Y, Takai T, Nakamura T, Mitsuishi K, Gunawan H, Suto H,Ogawa T, Wang XL, Ikeda S, Okumura K, Ogawa H
    • Journal Title

      J Invest Dermatol

      Volume: 130 Pages: 614-617

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cedar allergen harvest from tobacco: Plant biotechnology for recombinant allergens2010

    • Author(s)
      Takai T
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 153 Pages: 431-433

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] lucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in atopic cytokine milieu more effectively than tacrolimus2010

    • Author(s)
      Le TA, Takai T, Vu AT, Kinoshita H, Ikeda S, Ogawa H, Okumura K
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 153 Pages: 27-34

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proinflammatory response in human keratinocytes stimulated with ligands for TLR2, TLR1, and TLR62010

    • Author(s)
      Vu AT, Takai T, Le TA, Kinoshita H, Kamijo S, Hara M, Wang XL, Ogawa T, Ikeda S, Ogawa H, Okumura K
    • Journal Title

      Juntendo Medical Journal

      Volume: 56 Pages: 50-55

    • NAID

      10029497982

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ダニに由来する Th2 アジュバント活性2010

    • Author(s)
      高井敏朗
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 619-624

    • Related Report
      2012 Final Research Report
  • [Journal Article] 花粉の Th2 アジュバント活性2010

    • Author(s)
      高井敏朗、上條清嗣
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 625-630

    • Related Report
      2012 Final Research Report
  • [Journal Article] 樹状細胞の花粉成分による Th2 細胞誘導2010

    • Author(s)
      上條清嗣、奥村康、高井敏朗
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 313-322

    • Related Report
      2012 Final Research Report
  • [Journal Article] アレルゲンに対する自然免疫応答2010

    • Author(s)
      高井敏朗
    • Journal Title

      呼吸

      Volume: 29 Pages: 878-883

    • Related Report
      2012 Final Research Report
  • [Journal Article] 知っておかなければならないアレルギー疾患の基礎知識2010

    • Author(s)
      高井敏朗
    • Journal Title

      (2) Th2 アジュバントとしてのアレルゲン アレルギー・免疫

      Volume: 17 Pages: 687-694

    • Related Report
      2012 Final Research Report
  • [Journal Article] 花粉による樹状細胞の活性化2010

    • Author(s)
      上條清嗣、奥村康、高井敏朗
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53 Pages: 312-320

    • NAID

      40017058245

    • Related Report
      2012 Final Research Report
  • [Journal Article] 環境因子とアレルギー疾患-特にアトピー性皮膚炎を中心にー2010

    • Author(s)
      奥村康、高井敏朗
    • Journal Title

      日中医学

      Volume: 24 Pages: 47-52

    • NAID

      10026237937

    • Related Report
      2012 Final Research Report
  • [Journal Article] Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes via the Toll-like receptor 2-Toll-like receptor 6 pathway2010

    • Author(s)
      Vu, Anh Tuan
    • Journal Title

      J Allergy Clin Immunol

      Volume: 126

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 表皮ケラチノサイトにおけるTSLP産生誘導

    • Author(s)
      高井敏朗
    • Journal Title

      臨床免疫・アレルギー科

      Volume: (印刷中)

    • NAID

      40018789102

    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013

    • Author(s)
      Toshiro Takai
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milano, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Contribution of adaptive immune cells and IL-33-mediated innate response to protease allergen-dependent allergic airway inflammation2013

    • Author(s)
      Toshiro Takai
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, Type 2 immunity: initiation, maintenance, homeostasis and pathology
    • Place of Presentation
      Santa Fe, New Mexico, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Symposium S3E-32. New frontiers in molecular mechanisms of allergic diseases. Allergens and their Th2 adjuvant activity2012

    • Author(s)
      Toshiro Takai
    • Organizer
      日本薬理学会
    • Place of Presentation
      京都国際会館(京都府)(招請)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレルゲンはなぜアレルゲンになるのか?:Th2/IgE誘導アジュバントとしてのアレルゲンおよび黄色ブドウ球菌2012

    • Author(s)
      高井敏朗
    • Organizer
      日本耳鼻咽喉アレルギー免疫学会
    • Place of Presentation
      琵琶湖ホテル(滋賀県)(招請)
    • Year and Date
      2012-02-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレルゲンの持つアジュバント作用と抗原感作機構2012

    • Author(s)
      高井敏朗
    • Organizer
      大阪皮膚アレルギーネットワーク(ODAN)
    • Place of Presentation
      ANAクラウンプラザホテル大阪(大阪府)(招請)
    • Year and Date
      2012-01-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Protease allergen and barrier injury synergistically induce skin inflammation and antibody production2012

    • Author(s)
      Hideo Iida
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      那覇
    • Related Report
      2012 Annual Research Report
  • [Presentation] Modulation of double-stranded RNA- and cytokine-induced responses of human keratinocytes by LL-372012

    • Author(s)
      Xue Chen
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      那覇
    • Related Report
      2012 Annual Research Report
  • [Presentation] 9-cis-retinoic acid inhibits TLR ligand- and cytokine-induced TSLP production in human keratinocytes2012

    • Author(s)
      Yang Xie
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      那覇
    • Related Report
      2012 Annual Research Report
  • [Presentation] Contribution of adaptive immune cells and IL-33-mediated innate response to protease allergen-dependent allergic airway inflammation2012

    • Author(s)
      Seiji Kamijo
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロテアーゼアレルゲンによる気道炎症における獲得免疫細胞およびIL-33を介した自然免疫応答の役割2012

    • Author(s)
      上條清嗣
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] スギヒノキ花粉症患者鼻粘膜擦過細胞におけるフィラグリンの発現2012

    • Author(s)
      三輪正人
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Epidermal barrier dysfunction induced by environmental proteases2012

    • Author(s)
      Hideo Iida
    • Organizer
      2th Annual European Society for Dermatological Research Meeting
    • Place of Presentation
      Venice, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] The long form TSLP functions in the Toll-like receptor ligand- or cytokine-induced TSLP release in human keratinocytes2012

    • Author(s)
      Yang Xie
    • Organizer
      第42回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      長野
    • Related Report
      2012 Annual Research Report
  • [Presentation] The long form TSLP functions in the Toll-like receptor ligand- or cytokine-induced TSLP release in human keratinocytes2012

    • Author(s)
      Yang Xie
    • Organizer
      The 2nd Eastern Asia Dermatology Congress
    • Place of Presentation
      Beijing, Chin
    • Related Report
      2012 Annual Research Report
  • [Presentation] Th2アジュバントとしてのアレルゲン:バリアと自然免疫系に対する作用2012

    • Author(s)
      高井敏朗
    • Organizer
      日本アレルギー学会春季臨床大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Staphylococcus aureus-derived extracellular protease and membranous TLR2-TLR6 ligand induce skin barrier dysfunction and production of TSLP2011

    • Author(s)
      Toshiro Takai, et al
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] シンポジウム15.免疫細胞と組織構成細胞の接点.環境→Th2応答への橋渡し:TLRリガンドによる上皮からのTSLP産生誘導2011

    • Author(s)
      高井敏朗
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] シンポジウム11.環境と体内物質のTh2Tジュバント作用.プロテアーゼアレルゲンおよび花粉によるTh2アジュバント作用2011

    • Author(s)
      上條清嗣, 他
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 教育講演1.アレルゲンとは何か:3つの顔2011

    • Author(s)
      高井敏朗
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)(招請)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] APAPARI Sympoium : Allergen. Environmental allergens and their Th2 adjuvant activity2011

    • Author(s)
      Toshiro Takai
    • Organizer
      Joint Congress of Asia Pacific Association of Pediatric Allergy, Respirology & Immunology 2011 (APAPARI 2011) and 48th Annual Meeting of Japanese Society of Pediatric Allergy and Clinical Immunology (48th JSPACI)
    • Place of Presentation
      福岡国際会議場(福岡県)(招請)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレルゲンを考える:アレルゲンはなぜアレルゲンになるのか?2011

    • Author(s)
      高井敏朗
    • Organizer
      那須ティーチイン
    • Place of Presentation
      ホテルマリナーズコート東京(東京都)(招請)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「なぜアレルゲンはアレルゲンになるのか?」広義のTh2/IgE誘導アジュバントとしての環境アレルゲンおよび黄色ブドウ球菌2011

    • Author(s)
      高井敏朗
    • Organizer
      日本皮膚アレルギー学会
    • Place of Presentation
      富士屋ホテル(山梨県)(招請)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] TLR ligands and cytokines induce expression of the long splice form of TSLP mRNA in human keratinocytes2011

    • Author(s)
      Yang Xie, et al
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Extracellular double stranded RNA induces TSLP via TLR3-NF-κB axis in human keratinocytes2011

    • Author(s)
      Xue Chen, et al
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epidermal barrier dysfunction induced by environmental proteases2011

    • Author(s)
      Hideo Iida, et al
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Induction of TSLP in keratinocytes stimulated with bacteria-related TLR ligands2010

    • Author(s)
      Chen, Xue
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of nuclear receptor agonists and calcineurin inhibitors on induct i on of TSLP in ketratinocytes2010

    • Author(s)
      Xie, Yang
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      和歌山
    • Related Report
      2010 Annual Research Report
  • [Presentation] 教育講演:なぜアレルゲンはアレルゲンになるのか2010

    • Author(s)
      高井敏朗
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Staphylococcus aureus membrane and diacyllipopeptide induces TSLP in human keratinocytes via TLR2-TLR6 pathway2010

    • Author(s)
      Vu, Anh Tuan
    • Organizer
      19th Regional Conference of Dermatology(Asian-Australian)
    • Place of Presentation
      Kota kinabalu, Malaysia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Response of epidermis and epithelium against allergens, viral/microbial components, or endogenous factors : barrier disruption, proinflammatory responses, and homeostasis2010

    • Author(s)
      Takai, Toshiro
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] TSLPおよびIL-33の産生誘導とアレルギー

    • Author(s)
      高井敏朗
    • Organizer
      喘息治療セミナー21(ロイコトリエン研究会)
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] アレルゲンの持つアジュバント作用と抗原感作機構

    • Author(s)
      高井敏朗
    • Organizer
      第10回 九州耳鼻科薬物治療研究会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] アレルゲンの持つアジュバント作用と抗原感作機構

    • Author(s)
      高井敏朗
    • Organizer
      茨城県小児アレルギー研究会
    • Place of Presentation
      つくば
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] アレルゲン研究の最前線

    • Author(s)
      高井敏朗
    • Organizer
      関東耳鼻咽喉科アレルギー懇話会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Mite endopeptidase 1. In: Neil D. Rawlings and Guy S2013

    • Author(s)
      Takai T
    • Publisher
      alvesen, editors, Handbook of Proteolytic Enzymes. Oxford: Academic Press
    • Related Report
      2012 Final Research Report
  • [Book] Serine endopeptidase allergens from Dermatophagoidesspecies. In: Neil D. Rawlings and Guy S2013

    • Author(s)
      Takai T
    • Publisher
      Salvesen, editors, Handbook of Proteolytic Enzymes. Oxford: Academic Press
    • Related Report
      2012 Final Research Report
  • [Book] Methods in Enzymology: Endosomal Signaling: TSLP expression induced via Toll-like receptor pathways in human keratinocytes2013

    • Author(s)
      Toshiro Takai
    • Publisher
      Elsevier
    • Related Report
      2012 Annual Research Report
  • [Book] Handbook of Proteolytic Enzymes: Mite endopeptidase 12013

    • Author(s)
      Toshiro Takai
    • Publisher
      Academic Press
    • Related Report
      2012 Annual Research Report
  • [Book] Handbook of Proteolytic Enzymes: Serine endopeptidase allergens from Dermatophagoides species2013

    • Author(s)
      Toshiro Takai
    • Publisher
      Academic Press
    • Related Report
      2012 Annual Research Report
  • [Remarks] アトピー疾患研究センター 高井敏朗 研究内容

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/kenkyu_takai.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/kenkyu_takai.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/k9.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi