| Project/Area Number |
22591260
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
WAKUDA Tomoyasu (2011-2012) 浜松医科大学, 医学部, 助教 (80444355)
山本 茂幸 (2010) Hamamatsu University School of Medicine, 助教 (10382201)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Norio 浜松医科大学, 医学部, 教授 (00174376)
NAKAMURA Kazuhiko 弘前大学, 医学部, 教授 (80263911)
TAKEBAYASHI Kiyokazu 浜松医科大学, 医学部附属病院, 講師 (50397428)
SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040)
MOCHIZUKI Yosuke 浜松医科大学, 医学部附属病院, 臨床心理士 (30568572)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 中毒性精神障害 / アルコール依存 / MRI / 神経画像 / アルコール依存症 / 認知機能 / BDNF |
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| Research Abstract |
Cognitive dysfunction and brain atrophy observed in alcoholics could improve partially by abstinence. Brain-derived neurotrophic factor (BDNF), a factor adjusting the neuronal growth, synaptic functions, and survival and growth of neurons in the brain, shows neuroprotective effects. Polymorphism of the BDNF gene has been associated with risk of neuropsychiatric disorders such as schizophrenia and mood disorders, although relationship between BDNF gene polymorphism and recovery from alcohol intoxication is unclear. In this study, we examined this issue. As a result, we found no significant effect of BDNF gene polymorphism in the control as well as patients groups in any of neuroimaging findings, suggesting that further evaluations with more participants will be required.
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