Involvement of brain-derived neurotrophic factor gene polymorphism on the central nervous system disorders of alcoholics

• Project/Area Number: 22591260
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: WAKUDA Tomoyasu (2011-2012) 浜松医科大学, 医学部, 助教 (80444355); 山本 茂幸 (2010) Hamamatsu University School of Medicine, 助教 (10382201)
• Co-Investigator(Kenkyū-buntansha): MORI Norio 浜松医科大学, 医学部, 教授 (00174376) ; NAKAMURA Kazuhiko 弘前大学, 医学部, 教授 (80263911) ; TAKEBAYASHI Kiyokazu 浜松医科大学, 医学部附属病院, 講師 (50397428) ; SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040) ; MOCHIZUKI Yosuke 浜松医科大学, 医学部附属病院, 臨床心理士 (30568572)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 中毒性精神障害 / アルコール依存 / MRI / 神経画像 / アルコール依存症 / 認知機能 / BDNF

Research Abstract

Cognitive dysfunction and brain atrophy observed in alcoholics could improve partially by abstinence. Brain-derived neurotrophic factor (BDNF), a factor adjusting the neuronal growth, synaptic functions, and survival and growth of neurons in the brain, shows neuroprotective effects. Polymorphism of the BDNF gene has been associated with risk of neuropsychiatric disorders such as schizophrenia and mood disorders, although relationship between BDNF gene polymorphism and recovery from alcohol intoxication is unclear. In this study, we examined this issue. As a result, we found no significant effect of BDNF gene polymorphism in the control as well as patients groups in any of neuroimaging findings, suggesting that further evaluations with more participants will be required.

Research Products

• [Journal Article] Microglial activation in young adults with autism spectrum disorder (2013)
  • Author(s): Suzuki K
  • Journal Title: JAMA Psychiatry Volume: 70 Issue: 1 Pages: 49-58
  • DOI: 10.1001/jamapsychiatry.2013.272
  • Peer Reviewed
• [Journal Article] Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism (2013)
  • Author(s): Shimmura C
  • Journal Title: Molecular Autism Volume: 4 Issue: 1 Pages: 6-6
  • DOI: 10.1186/2040-2392-4-6
  • Peer Reviewed
• [Journal Article] Vldlr overexpression causes hyperactivity in rats. (2012)
  • Author(s): Iwata K
  • Journal Title: Mol Autism. Volume: 3 Issue: 1 Pages: 11-11
  • DOI: 10.1186/2040-2392-3-11
  • Peer Reviewed
• [Journal Article] Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging (2011)
  • Author(s): Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi Y
  • Journal Title: Neurosci Volume: 31 Issue: 31 Pages: 11193-9
  • DOI: 10.1523/jneurosci.2535-11.2011
  • Peer Reviewed
• [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders (2011)
  • Author(s): Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
  • Journal Title: Arch Gen Psychiatry Volume: 68 Issue: 3 Pages: 306-13
  • DOI: 10.1001/archgenpsychiatry.2011.4
• [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility. (2011)
  • Author(s): Nakamura K, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35 Issue: 2 Pages: 454-8
  • DOI: 10.1016/j.pnpbp.2010.11.033
• [Journal Article] In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease (2011)
  • Author(s): Yok oku r a M, Mo r i N, Yag i S, Yos h ik awa E, Kikuchi M, Yoshihara Y, Wakuda T, Sugihara G, Takebayashi K, Suda S, Iwata Y, Ueki T, Tsuchiya KJ, Suzuki K, Nakamura K, Ouchi Y
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 38 Issue: 2 Pages: 343-51
  • DOI: 10.1007/s00259-010-1612-0
• [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis (2011)
  • Author(s): Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T
  • Journal Title: Am J Med Genet B Neuro- psychiatr Genet Volume: 153 Issue: 6 Pages: 1221-7
  • DOI: 10.1002/ajmg.b.31095
• [Journal Article] Alteration of Plasma Glutamate and Glutamine Levels in Children with High-Functioning Autism (2011)
  • Author(s): Shimmura C, Suda S, Tsuchiya KJ, Hashimoto K, Ohno K, Matsuzaki H, Iwata K, Matsumoto K, Wakuda T, Kameno Y, Suzuki K, Tsujii M, Nakamura K, Takei N, Mori N
  • Journal Title: PLoS One Volume: 6(10) Issue: 10 Pages: e25340-e25340
  • DOI: 10.1371/journal.pone.0025340
  • Peer Reviewed
• [Journal Article] Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder (2010)
  • Author(s): Suzuki K, Iwata Y, Matsuzaki H, Anitha A, Suda S, Iwata K, Shinmura C, Kameno Y, Tsuchiya KJ, Nakamura K, Takei N, Mori N
  • Journal Title: Prog Neuropsycho- pharmacol Biol Psychiatry Volume: 34 Issue: 6 Pages: 1007-10
  • DOI: 10.1016/j.pnpbp.2010.05.014