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2012 Fiscal Year Final Research Report

Involvement of brain-derived neurotrophic factor gene polymorphism on the central nervous system disorders of alcoholics

Research Project

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Project/Area Number 22591260
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

WAKUDA Tomoyasu  浜松医科大学, 医学部, 助教 (80444355)

Co-Investigator(Kenkyū-buntansha) MORI Norio  浜松医科大学, 医学部, 教授 (00174376)
NAKAMURA Kazuhiko  弘前大学, 医学部, 教授 (80263911)
TAKEBAYASHI Kiyokazu  浜松医科大学, 医学部附属病院, 講師 (50397428)
SUZUKI Katsuaki  浜松医科大学, 医学部, 准教授 (00285040)
MOCHIZUKI Yosuke  浜松医科大学, 医学部附属病院, 臨床心理士 (30568572)
Project Period (FY) 2010 – 2012
Keywords中毒性精神障害 / アルコール依存 / MRI
Research Abstract

Cognitive dysfunction and brain atrophy observed in alcoholics could improve partially by abstinence. Brain-derived neurotrophic factor (BDNF), a factor adjusting the neuronal growth, synaptic functions, and survival and growth of neurons in the brain, shows neuroprotective effects. Polymorphism of the BDNF gene has been associated with risk of neuropsychiatric disorders such as schizophrenia and mood disorders, although relationship between BDNF gene polymorphism and recovery from alcohol intoxication is unclear. In this study, we examined this issue. As a result, we found no significant effect of BDNF gene polymorphism in the control as well as patients groups in any of neuroimaging findings, suggesting that further evaluations with more participants will be required.

  • Research Products

    (7 results)

All 2013 2011 2010

All Journal Article (7 results)

  • [Journal Article] Microglial activation in young adults with autism spectrum disorder2013

    • Author(s)
      Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y, Tsujii M, Sugiyama T, Mori N
    • Journal Title

      JAMA Psychiatry

      Volume: 70 Pages: 49-58

    • DOI

      DOI:10.1001/jamapsychiatry.2013.272

  • [Journal Article] Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging2011

    • Author(s)
      Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi Y
    • Journal Title

      J Neurosci

      Volume: 31 Pages: 11193-9

    • DOI

      DOI:10.1523/JNEUROSCI.2535-11.2011

  • [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011

    • Author(s)
      Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
    • Journal Title

      Arch Gen Psychiatry

      Volume: 68 Pages: 306-13

    • DOI

      DOI:10.1001/archgenpsychiatry.2011.4

  • [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility2011

    • Author(s)
      Nakamura K, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35 Pages: 454-8

    • DOI

      DOI:10.1016/j.pnpbp.2010.11.033

  • [Journal Article] In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease2011

    • Author(s)
      Yok oku r a M, Mo r i N, Yag i S, Yos h ik awa E, Kikuchi M, Yoshihara Y, Wakuda T, Sugihara G, Takebayashi K, Suda S, Iwata Y, Ueki T, Tsuchiya KJ, Suzuki K, Nakamura K, Ouchi Y
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 38 Pages: 343-51

    • DOI

      DOI:10.1007/s00259-010-1612-0

  • [Journal Article] Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder2010

    • Author(s)
      Suzuki K, Iwata Y, Matsuzaki H, Anitha A, Suda S, Iwata K, Shinmura C, Kameno Y, Tsuchiya KJ, Nakamura K, Takei N, Mori N
    • Journal Title

      Prog Neuropsycho- pharmacol Biol Psychiatry

      Volume: 34 Pages: 1007-10

    • DOI

      DOI:10.1016/j.pnpbp.2010.05.014

  • [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis.2010

    • Author(s)
      Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuro- psychiatr Genet

      Volume: 153 Pages: 1221-7

    • DOI

      DOI:10.1002/ajmg.b.31095

URL: 

Published: 2014-08-29  

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