| Project/Area Number |
22591290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Yoshito 佐賀大学, 医学部, 講師 (60467892)
KUNITAKE Yutaka 佐賀大学, 医学部, 助教 (30404198)
國武 裕 佐賀大学, 医学部, 助教 (30404148)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | saliva 3-methoxy-4-hydroxuphenylglycol / Mini-Mental State Examination / Frontal Assessment Battery / Beck Depression Inventory / 唾液 / MHPG / ハミルトンうつ病尺度 / MMSE / FAB / 認知症 / うつ病 / コホート研究 / 認知機能低下 / 縦断研究 / うつ状態 / 長鎖不飽和脂肪酸 / cortisol / 認知機能 / 高齢者 |
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| Research Abstract |
We previously reported that the saliva level of 3-methoxy-4-hydroxyphenylglycole (sMHPG) in 214 elderly subjects living in a community was negatively associated with scores on the Mini-Mental State Examination (MMSE) or Frontal Assessment Battery (FAB) from 2004 to 2006 (Time A). To assess the contribution of sMHPG for consequent cognitive decline in elderly subjects living in a community, the same cohort underwent these cognitive tests again from 2007 to 2009 (Time B). One hundred forty-seven of the original 214 subjects could be re-assessed using the same cognitive tests. FAB scores at Time B were significantly lower than at Time A. There was a significant negative correlation between baseline sMHPG levels and changes in FAB scores from time B to time A. Moreover, baseline sMHPG levels were negatively correlated with the FAB score at Time B, but not Time A. No correlation was found between baseline sMHPG levels and MMSE scores. High sMHPG could commit a consequent cognitive decline assessed by FAB in non-demented elderly subjects living in a community.
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