A prospective study to detect the factors to cause later cognitive decline or depressive state in Japanese elderly-Three years follow up study-

• Project/Area Number: 22591290
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Saga University
• Principal Investigator: YAMADA Shigeto 佐賀大学, 医学部, 客員研究員 (20158190)
• Co-Investigator(Kenkyū-buntansha): MIZOGUCHI Yoshito 佐賀大学, 医学部, 講師 (60467892) ; KUNITAKE Yutaka 佐賀大学, 医学部, 助教 (30404198) ; 國武 裕 佐賀大学, 医学部, 助教 (30404148)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: saliva 3-methoxy-4-hydroxuphenylglycol / Mini-Mental State Examination / Frontal Assessment Battery / Beck Depression Inventory / 唾液 / MHPG / ハミルトンうつ病尺度 / MMSE / FAB / 認知症 / うつ病 / コホート研究 / 認知機能低下 / 縦断研究 / うつ状態 / 長鎖不飽和脂肪酸 / cortisol / 認知機能 / 高齢者

Research Abstract

We previously reported that the saliva level of 3-methoxy-4-hydroxyphenylglycole (sMHPG) in 214 elderly subjects living in a community was negatively associated with scores on the Mini-Mental State Examination (MMSE) or Frontal Assessment Battery (FAB) from 2004 to 2006 (Time A). To assess the contribution of sMHPG for consequent cognitive decline in elderly subjects living in a community, the same cohort underwent these cognitive tests again from 2007 to 2009 (Time B). One hundred forty-seven of the original 214 subjects could be re-assessed using the same cognitive tests. FAB scores at Time B were significantly lower than at Time A. There was a significant negative correlation between baseline sMHPG levels and changes in FAB scores from time B to time A. Moreover, baseline sMHPG levels were negatively correlated with the FAB score at Time B, but not Time A. No correlation was found between baseline sMHPG levels and MMSE scores. High sMHPG could commit a consequent cognitive decline assessed by FAB in non-demented elderly subjects living in a community.

Research Products

• [Journal Article] Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole (MHPG) associates with a consequent cognitive decline in non-demented elderly subjects: three-years follow-up study (2012)
  • Author(s): Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Furukawa Y, Tateishi H, Kojima N, Mizoguchi Y, Yamada S
  • Journal Title: Psychiatry Res Volume: 195(3) Pages: 125-8
  • Peer Reviewed
• [Journal Article] Association of saliva 3-methoxy-4-hydroxyphenylglycol levels and a later depressive state in older subjects living in a rural community: 3-year follow-up study (2012)
  • Author(s): Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Kojima N, Yamada S
  • Journal Title: Int J Geriatr Psychiatry Volume: 27(3) Pages: 321-6
  • Peer Reviewed
• [Journal Article] The effect of oral presentation on salivary 3-methoxy-4- hydroxy-phenylglycol (MHPG) and cortisol concentrations in training doctors: a preliminary study (2012)
  • Author(s): Mizoguchi Y, Sakami A, Imamura Y, Tsuruta T, Egami M, Yamada S
  • Journal Title: Endocrine. Volume: 42(3) Pages: 752-3
  • Peer Reviewed
• [Journal Article] Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole (MHPG) associates with a consequent cognitive decline in non-demented elderly subjects: three-years follow-up study. (2012)
  • Author(s): Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Furukawa Y, Tateishi H, Kojima N, Nizoguchi Y, Yamada S.
  • Journal Title: Psychiatry Res. Volume: 195 Pages: 125-128
  • Peer Reviewed
• [Journal Article] Association of saliva 3-methoxy-4-hydroxyphenylglycol levels and a later depressive state in older subjects living in a rural community: 3-year follow-up study. (2012)
  • Author(s): Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Kojima N, Yamada S.
  • Journal Title: Int J Geriatr Psychiatry Volume: 27 Pages: 321-326
  • Peer Reviewed
• [Journal Article] The effect of oral presentation on salivary 3-methoxy-4-hydroxy-phenylglycol (MHPG) and cortisol concentrations in training doctors: a preliminary study. (2012)
  • Author(s): Mizoguchi Y, Sakami A, Imamura Y, Tsuruta T, Egami M, Yamada S
  • Journal Title: Endocrine Volume: 42 Pages: 752-753
  • Peer Reviewed
• [Journal Article] Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole (MHPG) associates with a consequent cognitive decline in non-demented elderly subjects : Three-years follow-up study (2012)
  • Author(s): Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Furukawa Y, Tateishi H, Kojima N, Nizoguchi Y, Yamada S
  • Journal Title: Psychiatry Res Volume: 195 Pages: 125-128
  • Peer Reviewed
• [Journal Article] Association of saliva 3-methoxy-4-hydroxyphenylglycol levels and a later depressive state in older subjects living in a rural community : 3-year follow-up study (2012)
  • Author(s): Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Kojima N, Yamada S
  • Journal Title: Int J Geriatr Psychiatry Volume: 27 Pages: 321-326
  • Peer Reviewed
• [Presentation] 認知機能低下予測指標としてのVSRADの有用性 (2010)
  • Author(s): 渡邉至、今村義臣、國武裕、鍋田紘美、石井博修、古川祐三、原口祥典、松島淳、小島直樹、山田茂人
  • Organizer: 第30回日本精神神経科診断学会
  • Place of Presentation: 福岡市
• [Presentation] 國武裕、石川謙介、渡邉至、今村義臣、鍋田紘美、石井博修、古川祐三、原口祥典、松島淳、菅高一博、村岡稔史、小島直樹、山田茂人 (2010)
  • Author(s): 國武裕、石川謙介、渡邉至、今村義臣、鍋田紘美、石井博修、古川祐三、原口祥典、松島淳、菅高一博、村岡稔史、小島直樹、山田茂人
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 東京
• [Presentation] 認知機能低下の予見因子としての唾液中3-methoxy-4-hydroxyphenylglycol の検討 (2010)
  • Author(s): 渡邉至、國武裕、今村義臣、鍋田紘美、石井博修、古川祐三、原口祥典、松島淳、小島直樹、山田茂人
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州市
• [Presentation] 認知機能低下の予見因子としての唾液中3-methoxy-4-hydroxyphenylglycolの検討 (2010)
  • Author(s): 渡邉至、國武裕、今村義臣、鍋田紘美、石井博修、古川祐三、原口祥典、松島淳、小島直樹、山田茂人
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州市
• [Presentation] 配偶者の有無による前頭葉機能検査の桂二的変化の男女差 (2010)
  • Author(s): 國武裕、石川謙介、渡邉至、今村義臣、鍋田紘美、石井博修、古川祐三、原口祥典、松島淳、菅高一博、村岡稔史、小島直樹、山田茂人
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 東京