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The prediction of psychosis in Alzheimer disease usedby both morphometric and diffusion-tensor imaging

Research Project

Project/Area Number 22591293
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKeio University (2012)
Nagoya City University (2010-2011)

Principal Investigator

NAKAAKI Shutaro  慶應義塾大学, 医学部, 特任准教授 (80315879)

Co-Investigator(Kenkyū-buntansha) MIMURA Masaru  慶應義塾大学, 医学部, 教授 (00190728)
MURAI Toshiya  京都大学, 医学(系)研究科(研究院), 教授 (30335286)
MIYATA Jun  京都大学, 医学(系)研究科(研究院), 助教 (90549099)
古川 壽亮  名古屋市立大学, 大学院・医学研究科, 教授 (90275123)
Co-Investigator(Renkei-kenkyūsha) FURUKAWA Toshiaki  京都大学, 医学(系)研究科(研究院), 教授 (90275123)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords老年精神医学 / 拡散テンソル画像 / 脳形態画像 / 脆弱性 / アルツハイマー病 / 精神症状 / 形態画像 / テンソル画像 / 認知症 / VBM / 高次脳機能
Research Abstract

Whether the neural substrate underlying the delusions developsbefore the onset of the delusions is unclear. In this study, weused both a voxel-based morphometry (VBM) approach and a diffusion tensor imaging (DTI)approach to examine the existence of region

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (10 results) Book (7 results) Remarks (2 results)

  • [Journal Article] Behavior management approach for agitated behavior in Japanese patients with dementia: a pilot study2013

    • Author(s)
      Sato, J., Nakaaki, S., Torii, K.,Oka, M.,Mimura, M.
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 9 Pages: 9-14

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroanatomical abnormalities before onset of delusions in patients with Alzheimer's disease: a voxel-based morphometry study2013

    • Author(s)
      Nakaaki, S., Sato, J., Torii, K., Oka, M., Miyata, J., Mimura, M
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 9 Pages: 1-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased white matter integrity before the onset of delusions in patients with Alzheimer's disease: diffusion tensor imaging2013

    • Author(s)
      Nakaaki, S., Sato, J., Torii, K., Oka, M., Miyata, J., Mimura, M.
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 9 Pages: 25-29

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroanatomical abnormalities before the onset of different types of delusions in a patient with Alzheimer disease2013

    • Author(s)
      Nakaaki, S., Sato, J., Torii, K., Kawaguchi,T,Kawaguchi,A,, Narumoto.J.,Mimura,M.
    • Journal Title

      J Neuropsychiatry Clin Neursci

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction in white matter before and after the development of delusions of theft in a patient with Alzheimer Disease2013

    • Author(s)
      Nakaaki, S., Sato, J., Torii, K.,Kawaguchi,T,Kawaguchi,A,,Narumoto. J.,Mimura, M.
    • Journal Title

      J Neuropsychiatry Clin Neursci

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroanatomical abnormalities before onset of delusions in patients with Alzheimer’s disease: a voxel-based morphometry study2013

    • Author(s)
      Shutaro Nakaaki
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 9 Pages: 1-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased white matter integrity before the onset of delusions in patients with Alzheimer’s disease: diffusion tensor imaging2013

    • Author(s)
      Shutaro Nakaaki
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 9 Pages: 25-29

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroanatomical abnormalities before the onset of different types of delusions in a patient with Alzheimer disease.2013

    • Author(s)
      Shutaro Nakaaki
    • Journal Title

      J Neuropsychiatry Clin Neursci

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction in white matter before and after the development of delusions of theft in a patient with Alzheimer Disease2013

    • Author(s)
      Shutaro Nakaaki
    • Journal Title

      J Neuropsychiatry Clin Neursci

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 失語症者の家族介護者におけるコミュニケーション自己効力感評価尺度2012

    • Author(s)
      辰巳 寛、山本 正彦、仲秋秀太郎、波多野 和夫
    • Journal Title

      高次脳機能研究

      Volume: 32 Pages: 514-524

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropsychological and functional correlates of clock-drawing test in elderlyinstitutionalized patients with schizophrenia2012

    • Author(s)
      Okamura, A., Kitabayashi, Y., Kohigashi, M., Shibata, K., Ishida, T., Narumoto, J.,Morioka, C., Kitabayashi, M., Kashima, A., Tani, N., Nakaaki S, Mimura M, Fukui, K
    • Journal Title

      Psychogeriatrics

      Volume: 12 Pages: 242-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] patients'distress and self-awareness of deficits in Alzheimer's disease2012

    • Author(s)
      Maki, Y., Amari, M., Yamaguchi, T., Nakaaki, S., Yamaguchi, H. Anosognosia
    • Journal Title

      Am J AlzheimersDis Other Demen

      Volume: 27 Pages: 339-45

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reliability and validity of the Japaneseversion of the Agitated Behaviour in Dementia Scale in Alzheimer's disease : three dimensions of agitated behaviour in dementia2011

    • Author(s)
      Torii Katsuyoshi
    • Journal Title

      Psychogeriatrics

      Volume: 11 Issue: 4 Pages: 212-220

    • DOI

      10.1111/j.1479-8301.2011.00371.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of the Quality of Life-Alzheimer's Disease Scale for mild cognitive impairment2011

    • Author(s)
      Hiroshi Tatsumi
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 65 Issue: 5 Pages: 533-533

    • DOI

      10.1111/j.1440-1819.2011.02245.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case with Hodgkin lymphoma and fronto-temporal lobular degeneration (FTLD)-like dementia facilitated by chemotherapy.2010

    • Author(s)
      Katsumata Ryuta
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 40 Pages: 365-368

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of mood : guides for clinicians2010

    • Author(s)
      Furukawa Toshiaki
    • Journal Title

      Journal of Psychosomatic Research

      Volume: 68 Pages: 581-589

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors of error and effort in memory intervention for patients with Alzheimer's disease and amnesic syndrome.2010

    • Author(s)
      Mimura Masaru
    • Journal Title

      Psychogeriatrics

      Volume: 10 Pages: 179-186

    • NAID

      10029771284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳血流SPECT によるアルツハイマー病の焦燥感と関連する脳部位の検討2012

    • Author(s)
      阪野公一, 仲秋秀太郎, 根木 惇, 鳥井勝義, 橋本伸彦, 佐藤順子,宮田 淳, 成本 迅, 明智龍男, 三村 將
    • Organizer
      第36回日本神経心理学会総会
    • Place of Presentation
      東京 学術総合センター
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 認知症の精神症状に対する行動的介入療法の検証-認知症 3 例に関する予備的な報告-2012

    • Author(s)
      佐藤順子,仲秋秀太郎, 鳥井勝義, 阪野公一, 根木 惇, 宮 裕昭, 成本 迅, 山中克夫, 辰巳 寛, 三村 將
    • Organizer
      第27回日本老年精神医学会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2012-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳形態と拡散テンソル画像によるアルツハイマー病の精神症状出現予測の検討2012

    • Author(s)
      仲秋秀太郎,佐藤順子,鳥井勝義,阪野公一,根木 惇,宮 裕昭,成本 迅,山中克夫,辰巳 寛,宮田 淳,川口毅恒,三村 將
    • Organizer
      第27回日本老年精神医学会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2012-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 認知症の精神症状に対する行動的介入療法の効果研究2012

    • Author(s)
      佐藤順子, 仲秋秀太郎, 鳥井勝義, 阪野公一, 根木 惇, 辰巳 寛, 三村 將
    • Organizer
      第13回日本認知症ケア学会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2012-06-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳形態と拡散テンソル画像によるアルツハイマー病の精神症状出現予測の検討2012

    • Author(s)
      仲秋秀太郎
    • Organizer
      第27回日本老年精神医学会
    • Place of Presentation
      大宮ソニックシティ (埼玉県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 認知症の精神症状に対する行動的介入療法の効果研究2012

    • Author(s)
      佐藤順子
    • Organizer
      第13回日本認知症ケア学会
    • Place of Presentation
      アクトシティ浜松 (静岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 認知症の精神症状に対する行動的介入療法の検証-認知症3例に関する予備的な報告-2012

    • Author(s)
      佐藤順子
    • Organizer
      第27回日本老年精神医学会
    • Place of Presentation
      大宮ソニックシティ (埼玉県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳血流SPECTによるアルツハイマー病の焦燥感と関連する脳部位の検討2012

    • Author(s)
      阪野公一
    • Organizer
      第36回日本神経心理学会総会
    • Place of Presentation
      東京 学術総合センター (東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Agitation Behavior in Dementia Scale(ABID)の標準化の検討2011

    • Author(s)
      鳥井勝義
    • Organizer
      第26回日本老年精神医学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-06-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経心理学の限界点 日本サイコオンコロジー学会シンポジウム2010

    • Author(s)
      仲秋秀太郎
    • Organizer
      第23回日本サイコオンコロジー-学会 第10回日本認知療法学会 合同学会
    • Place of Presentation
      ウインクあいち(名古屋)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Book] コミュニュケーションからみた認知症.2013

    • Author(s)
      佐藤順子, 仲秋秀太郎. Alzheimer 病. 三村將, 飯干紀代子 編
    • Publisher
      医歯薬出版株式会社(印刷中)
    • Related Report
      2012 Final Research Report
  • [Book] 認知症ハンドブック2013

    • Author(s)
      仲秋秀太郎, 佐藤順子 周辺症状 人物誤認. 中島健二, 天野直二, 下濱俊, 富本秀和, 三村將 編.
    • Publisher
      医学書院(印刷中)
    • Related Report
      2012 Final Research Report
  • [Book] 認知症ハンドブック2013

    • Author(s)
      仲秋秀太郎. 周辺症状 .実行機能障害. 中島健二, 天野直二, 下濱俊, 富本秀和, 三村將 編
    • Publisher
      医学書院(印刷中)
    • Related Report
      2012 Final Research Report
  • [Book] 記憶障害. 脳とこころのプライマリケア 第2巻 知能の衰え2013

    • Author(s)
      仲秋秀太郎, 三村 將,池田学 編
    • Publisher
      シナジー出版社(印刷中)
    • Related Report
      2012 Final Research Report
  • [Book] 人物誤認2013

    • Author(s)
      仲秋秀太郎
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Book] 精神科研修ノート2011

    • Author(s)
      仲秋秀太郎(笠井清登, 村井俊哉, 三村將, 等編)
    • Publisher
      診断と治療社
    • Related Report
      2011 Annual Research Report
  • [Book] 認知症 薬物療法2.周辺症状.最新精神医学・別冊 新しい診断と治療のABC 66.2010

    • Author(s)
      仲秋秀太郎(三村將編)
    • Publisher
      最新医学社
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncupsychiatry.com/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncupsychiatry.com/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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