Angiogensis and desmoplasia of liver cancer derived from hepatic progenitor cell: imaging analysis

• Project/Area Number: 22591343
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: ASAYAMA Yoshiki 九州大学, 大学病院, 助教 (40380414)
• Co-Investigator(Kenkyū-buntansha): NISHIE Akihiro 九州大学, 大学病院, 助教 (20457427) ; FUJITA Nobuhiro 九州大学, 医学研究院, 助教 (30610612) ; USHIJIMA Yasuhiro 九州大学, 医学研究院, 助教 (40432934) ; TAKAYAMA Yukihisa 九州大学, 医学研究院, 助教 (60546563) ; HONDA Hiroshi 九州大学, 医学研究院, 助教 (90145433) ; NAKAYAMA Tomohiro 国立国際医療センター病院, 放射線診療部, 医師 (70419571) ; TAJIMA Tsuyoshi 東京女子医科大学, 画像診断学核医学講座, 准教授 (50346798) ; KAKIHARA Daisuke 九州大学, 医学研究院, 助教 (80529818) ; ISHIGAMI Kousei 九州大学, 大学病院, 助教 (10403916)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肝幹細胞 / 細胆管癌 / 肝細胞癌 / 胆管細胞癌 / CT / MRI / 線維化 / 脂肪化 / 肝腫瘤 / MRI(核磁気共鳴画像) / Gd-EOB-DTPA

Research Abstract

(1)Cholangiolocellular carcinoma has the dual imaging characteristics of hepatocellular carcinoma and cholangiocarcinoma. (2)Gadoxetic acid-enhanced MRI was found useful for differentiating intrahepatic cholangiocarcioma and poorly differentiated hepatocellular carcinoma, especially during the dynamic late phase.(3)The frequency of fatty change in pHCC, as well as in wHCC, is significantly higher than that of mHCC. One possible mechanism of it is intratumoral decreased arterial flow

Research Products

• [Journal Article] CT prediction ofhistological grade of hypervascular hepatocellular carcinoma: utility of theportal phase (2012)
  • Author(s): Nishie A, Yoshimitsu K, Okamoto D, Tajima T, Asayama Y, Ishigami K, KakiharaD, Nakayama T, Takayama Y, Shirabe K, Fujita N, Honda H
  • Journal Title: Jpn J Radiol Volume: 31(2) Pages: 89-98
  • Peer Reviewed
• [Journal Article] Hypovascular hepatic nodule showinghypointensity in the hepatobiliary phase of gadoxetic acid-enhanced MRI inpatients with chronic liver disease: prediction of malignant transformation (2012)
  • Author(s): Takayama Y, Nishie A, Nakayama T, Asayama Y, Ishigami K, Kakihara D, Ushijima Y, Fujita N, Hirakawa M, Honda H
  • Journal Title: Eur J Radiol Volume: 81(11) Pages: 3072-8
  • Peer Reviewed
• [Journal Article] Image quality of Gd-EOB-DTPA-enhanced magnetic resonance imaging of the liver using dual-source parallel radiofrequencytransmission technology: Comparison with the post-processing correction methodfor B1 inhomogeneity-induced signal loss (2012)
  • Author(s): Takayama Y, Nishie A, Asayama Y, Ishigami K, Kakihara D, Nakayama T, Yoshiura T, Obara M, Hirakawa M, Honda H
  • Journal Title: Eur J Radiol Volume: 81(11) Pages: 3035-40
  • Peer Reviewed
• [Journal Article] Uptake of Gd-EOB-DTPA by hepatocellular carcinoma : radiologic-pathologic correlation with special reference to bile production (2011)
  • Author(s): Asayama Y, et al
  • Journal Title: Eur J Radiol Volume: Dec;80(3)
  • Peer Reviewed
• [Journal Article] Imaging of cholangiolocellular carcinoma of the liver (2010)
  • Author(s): Asayama Y, et al.
  • Journal Title: Eur J Radiol. Volume: Jul ; 75(1)
  • Peer Reviewed
• [Journal Article] Uptake of Gd-EOB-DTPA by hepatocellular carcinoma : Radiologic-pathologic correlation with special reference of bile production (2010)
  • Author(s): Asayama Y, et al.
  • Journal Title: Eur J Radiol. Volume: Nov 23(epub)
  • Peer Reviewed
• [Presentation] Fatty change in poorly differentiated hepatocellular carcinoma: possible mechanism in relation todecreased arterial flow (2012)
  • Author(s): 浅山良樹ら
  • Organizer: 第98回北米放射線学会
  • Place of Presentation: シカゴ
• [Presentation] Distinguish intrahepatic cholangiocarcinoma from poorly differentiated hepatocellular carcinoma using gadoxetic acid-enhanced MRI (2012)
  • Author(s): 浅山良樹ら
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜市
• [Presentation] Distinguish intrahepatic cholangiocarcinoma from poorly differentiated hepatocellular carcinoma using gadoxetic acid-enhanced MRI (2012)
  • Author(s): 浅山良樹
  • Organizer: 第７２回日本医学放射線学会総会
  • Place of Presentation: 横浜市
• [Presentation] Fatty change in poorly differentiated hepatocellular carcinoma: possible mechanism in relation to decreased arterial flow (2012)
  • Author(s): 浅山良樹
  • Organizer: 第９８回北米放射線学会
  • Place of Presentation: シカゴ
• [Presentation] 動脈性消化管出血に対する動脈塞栓術の有用性についての検討 (2011)
  • Author(s): 浅山良樹ら
  • Organizer: 第70回日本医学放射線学会総会
• [Presentation] Gd-EOB-DTPA造影MRI肝細胞相にて造影剤の取り込みを認めた肝細胞癌の検討 (2010)
  • Author(s): 浅山良樹, 他
  • Organizer: 2010年度日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-04-10