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2012 Fiscal Year Final Research Report

Angiogensis and desmoplasia of liver cancer derived from hepatic progenitor cell: imaging analysis

Research Project

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Project/Area Number 22591343
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

ASAYAMA Yoshiki  九州大学, 大学病院, 助教 (40380414)

Co-Investigator(Kenkyū-buntansha) NISHIE Akihiro  九州大学, 大学病院, 助教 (20457427)
FUJITA Nobuhiro  九州大学, 医学研究院, 助教 (30610612)
USHIJIMA Yasuhiro  九州大学, 医学研究院, 助教 (40432934)
TAKAYAMA Yukihisa  九州大学, 医学研究院, 助教 (60546563)
HONDA Hiroshi  九州大学, 医学研究院, 助教 (90145433)
NAKAYAMA Tomohiro  国立国際医療センター病院, 放射線診療部, 医師 (70419571)
TAJIMA Tsuyoshi  東京女子医科大学, 画像診断学核医学講座, 准教授 (50346798)
KAKIHARA Daisuke  九州大学, 医学研究院, 助教 (80529818)
ISHIGAMI Kousei  九州大学, 大学病院, 助教 (10403916)
Project Period (FY) 2010 – 2012
Keywords肝幹細胞 / 細胆管癌 / 肝細胞癌 / 胆管細胞癌 / CT / MRI
Research Abstract

(1)Cholangiolocellular carcinoma has the dual imaging characteristics of hepatocellular carcinoma and cholangiocarcinoma. (2)Gadoxetic acid-enhanced MRI was found useful for differentiating intrahepatic cholangiocarcioma and poorly differentiated hepatocellular carcinoma, especially during the dynamic late phase.(3)The frequency of fatty change in pHCC, as well as in wHCC, is significantly higher than that of mHCC. One possible mechanism of it is intratumoral decreased arterial flow

  • Research Products

    (6 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] CT prediction ofhistological grade of hypervascular hepatocellular carcinoma: utility of theportal phase2012

    • Author(s)
      Nishie A, Yoshimitsu K, Okamoto D, Tajima T, Asayama Y, Ishigami K, KakiharaD, Nakayama T, Takayama Y, Shirabe K, Fujita N, Honda H
    • Journal Title

      Jpn J Radiol

      Volume: 31(2) Pages: 89-98

    • Peer Reviewed
  • [Journal Article] Hypovascular hepatic nodule showinghypointensity in the hepatobiliary phase of gadoxetic acid-enhanced MRI inpatients with chronic liver disease: prediction of malignant transformation2012

    • Author(s)
      Takayama Y, Nishie A, Nakayama T, Asayama Y, Ishigami K, Kakihara D, Ushijima Y, Fujita N, Hirakawa M, Honda H
    • Journal Title

      Eur J Radiol

      Volume: 81(11) Pages: 3072-8

    • Peer Reviewed
  • [Journal Article] Image quality of Gd-EOB-DTPA-enhanced magnetic resonance imaging of the liver using dual-source parallel radiofrequencytransmission technology: Comparison with the post-processing correction methodfor B1 inhomogeneity-induced signal loss2012

    • Author(s)
      Takayama Y, Nishie A, Asayama Y, Ishigami K, Kakihara D, Nakayama T, Yoshiura T, Obara M, Hirakawa M, Honda H
    • Journal Title

      Eur J Radiol

      Volume: 81(11) Pages: 3035-40

    • Peer Reviewed
  • [Presentation] Fatty change in poorly differentiated hepatocellular carcinoma: possible mechanism in relation todecreased arterial flow2012

    • Author(s)
      浅山良樹ら
    • Organizer
      第98回北米放射線学会
    • Place of Presentation
      シカゴ
    • Year and Date
      20121125-30
  • [Presentation] Distinguish intrahepatic cholangiocarcinoma from poorly differentiated hepatocellular carcinoma using gadoxetic acid-enhanced MRI2012

    • Author(s)
      浅山良樹ら
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      20120412-15
  • [Presentation] 動脈性消化管出血に対する動脈塞栓術の有用性についての検討2011

    • Author(s)
      浅山良樹ら
    • Organizer
      第70回日本医学放射線学会総会
    • Year and Date
      20110509-20

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Published: 2014-08-29  

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