Evaluation of vascular permeability imaging using 3D-FLAIRMRI sequence

• Project/Area Number: 22591345
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: SHIGEMATSU Yoshinori 熊本大学, 医学部附属病院, 助教 (00555766)
• Co-Investigator(Kenkyū-buntansha): HIRAI Toshinori 熊本大学, 大学院・生命科学研究部, 准教授 (40274724)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 核磁気共鳴画像(MRI) / 3次元FLAIR / MRI / FLAIR / 血管透過性

Research Abstract

3D FLAIR is an imaging method of MRI. The enhancing effect emergesby the contrast agent leaked into the cerebrospinal fluid and extravascular interstitialspaces, while the signal intensity of the flowing blood is strongly suppressed. Therefore,there is a possibility that 3D FLAIR can depict the vessel parts with vascular permeability.Our study revealed that the signal intensity of 3D FLAIR was reduced with blood flowvelocity of more than 0.25-0.5cm/sec and was stronger with contrast agent concentrationof less than 0.5mmol/L.

Research Products

• [Journal Article] Delayed CSF enhancement associatedwith Todd's paresis (2012)
  • Author(s): Uetani H, Hirai T, Kitajima M,Shiraishi S, Shigematsu Y, Iwashita K,Uchino K, Hirano T, Yamashita Y
  • Journal Title: Jpn J Radiol Volume: 30(3) Issue: 3 Pages: 271-3
  • DOI: 10.1007/s11604-011-0015-x
  • Peer Reviewed
• [Journal Article] Comparison of 3D FLAIR, 2DFLAIR, and 2D T2-weighted MR imaging ofbrain stem anatomy (2012)
  • Author(s): Kitajima M, Hirai T, Shigematsu Y,Uetani H, Iwashita K, Morita K, Komi M,Yamashita Y
  • Journal Title: AJNR Am Jneuroradiol Volume: 33(5) Issue: 5 Pages: 922-7
  • DOI: 10.3174/ajnr.a2874
  • Peer Reviewed
• [Journal Article] Delayed CSF enhancement associated with Todd's paresis (2012)
  • Author(s): Hiroyuki Uetani, et al
  • Journal Title: Jpn J Radiol Volume: 21(Ahead of print)
  • Peer Reviewed
• [Journal Article] Comparison of the added value of contrast-enhanced3D fluid-attenuated inversion recovery and magnetization-prepared rapid acquisition of gradient echo sequences in relation to conventional postcontrast T1-weighted images for the evaluation of leptomeningeal diseases at 3T (2010)
  • Author(s): Fukuoka H, Hirai T, Okuda T, ShigematsuY, Sasao A, Kimura E, Hirano T, Yano S,Murakami R, Yamashita Y
  • Journal Title: AJNR Am J Neuroradiol Volume: 31(5) Issue: 5 Pages: 868-73
  • DOI: 10.3174/ajnr.a1937
  • Peer Reviewed
• [Journal Article] Comparison of the Added Value of Contrast-Enhanced 3D Fluid-Attenuated Inversion Recovery and Magnetization-Prepared Rapid Acquisition of Gradient Echo Sequences in Relation to Conven-tional Postcontrast Ti-Weighted Images for the Evaluation of Leptomeningeal Diseases at 3T (2010)
  • Author(s): Hirofumi Fukuoka, et al.
  • Journal Title: American Journal of Neuroradiology (AJNR) Volume: 31 Pages: 868-873
  • Peer Reviewed
• [Remarks]
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22271155