MR-cellular density imaging for evaluation of early response to chemotherapy.

• Project/Area Number: 22591363
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: MATSUSHIMA Shigeru 愛知県がんセンター(研究所), 遺伝子医療研究部, 研究員 (70444297)
• Co-Investigator(Renkei-kenkyūsha): KINOSADA Yasutomi 岐阜大学, 大学院・医学系研究科, 教授 (50161526) ; ERA Seiichi 岐阜大学, 大学院・医学系研究科, 教授 (30152002)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 癌 / 早期治療効果判定 / 分子画像 / 細胞密度画像 / 機能画像 / 磁気共鳴 / 磁化移動効果 / 肝細胞特異性造影剤

Research Abstract

The aim of this study was to evaluate an early prediction of response to chemotherapy by MR-cellular density imaging. We developed " contrast enhance ratio in hepatocellular (CERH) imaging, Uptake CERH imaging " and " Equivalent cross-relaxation rate (ECR) imaging " as MR-cellular density imaging. Uptake CERH images can visualize heterogeneous and partial uptake liver function. ECR images can be applied early prediction of response to chemotherapy according to decrease of cellular density.

Research Products

• [Journal Article] Evaluation of parotid gland function using equivalent cross-relaxation rate imaging applied magnetization transfer effect. (2012)
  • Author(s): H. Shimizu, S. Matsushima, Y. Kinosada, H. Miyamura, T. Kubota, H. Osaki, M. Nakayama, M. Yoshimoto, T. Kodaira.
  • Journal Title: Journal of Radiation Research Volume: 53 Pages: 138-144
  • NAID: 10030023861
  • Peer Reviewed
• [Journal Article] Cellular Imaging Using Equivalent Cross-Relaxation Rate Technique in Rabbit VX-2 Tumor Model. (2011)
  • Author(s): H. Nishiofuku, S. Matsushima, O. Taguchi, Y. Inaba, H. Yamaura, Y. Sato, T. Tanaka and K. Kichikawa.
  • Journal Title: Cancer Informatics Volume: 10 Pages: 227-232
  • Peer Reviewed
• [Journal Article] Comparative intermolecular cross-relaxation studies of human hemoglobin in red blood cells and bovine serum albumin in solution. (2011)
  • Author(s): S. Era, M. Sogami, N. Uyesaka, M. Murakami, S. Matsushima and Y. Kinosada.
  • Journal Title: NMR Biomed. Volume: 24 Pages: 483-491
  • Peer Reviewed
• [Journal Article] Comparative ^1H NMR studies of saturation transfer in copolymer gels and mouse lenses. (2010)
  • Author(s): K. Nakamura, M. Sogami, S. Era, S. Matsushima, Y. Kinosa.
  • Journal Title: NMR Biomed Volume: 23(6) Pages: 584-591
  • Peer Reviewed
• [Journal Article] Cell-Weighted Imaging for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging-Initial Experience. (2010)
  • Author(s): H. Nishiofuku, S. Matsushima, Y. Inaba, H, Yamaura, Y. Sato, Y. Morishima, K. Kichikawa.
  • Journal Title: Korean Journal of Radiology Volume: 11(3) Pages: 327-332
  • Peer Reviewed
• [Presentation] Evaluated the correlation of uptake contrast enhanced ratio in hepato-biliary phase imaging to existing liver function tests. (2013)
  • Author(s): S. Matsushima, Y. Sato, H. Yamaura, M. Kato, D. Inoue, Y. Kinosada, S. Era, K. Takahashi, Y. Inaba
  • Organizer: 2013 European Congress of Radiology.
  • Place of Presentation: Austria Center, Vienna, Austria
• [Presentation] Evaluated the correlation of uptake contrast enhanced ratio in hepato-biliary phase imaging to existing liver function tests. (2013)
  • Author(s): S. Matsushima
  • Organizer: 2013 European Congress of Radiology
  • Place of Presentation: Austria Center (Vienna)
• [Presentation] Correlation of hepatocellular density and contrast enhance ratio in hepatocellular of the surrounding non-cancerous background liver tissue. (2012)
  • Author(s): S. Matsushima, Y. Sato, H. Yamaura, M. Kato, D Inoue Y. Kinosada, S. Era, T.Kurinobu, Kazuya Takahashi, Y Inaba
  • Organizer: Radiological Society of North America 98nd Scientific Assembly and Annual Meeting.
  • Place of Presentation: McCormick Place. Chicago, USA
  • Year and Date: 2012-11-27
• [Presentation] 細胞外マトリクスの造影効果を考慮したGd-EOB-DTPAの肝細胞相造影率画像 (2012)
  • Author(s): 松島秀, 佐藤洋造, 山浦秀和, 紀ノ定保臣, 惠良聖一, 高橋和也, 稲葉吉隆
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2012-09-06
• [Presentation] Intermolecular cross-relaxation rate(CR) and equivalent CR in protein gel (2012)
  • Author(s): S.Era, M. Sogami, S. Matsushima and Y. Kinosada
  • Organizer: International Conference on Magnetic Resonance in Biological Systems
  • Place of Presentation: Lyon Convention Center, France
• [Presentation] Correlation of hepatocellular density and the contrast enhance ratio in hepatocellular imaging. (2012)
  • Author(s): S. Matsushima, Y. Sato, H. Yamaura, M. Kato, D. Inoue, Y. Kinosada, S. Era, K. Takahashi, Y. Inaba
  • Organizer: 2012 European Congress of Radiology.
  • Place of Presentation: Austria Center,Vienna, Austria
• [Presentation] Intermolecular cross-relaxation rate(CR) and equivalent CR in protein gel. (2012)
  • Author(s): S.Era
  • Organizer: International Conference on Magnetic Resonance in Biological System
  • Place of Presentation: Lyon Convention Center(Lyon)
• [Presentation] Correlation of hepatocellular density and the contrast enhance ratio in hepatocellular imaging (2012)
  • Author(s): 松島秀
  • Organizer: 2012 European Congress of Radiology
  • Place of Presentation: Austria Center, Vienna, Austria
• [Presentation] Evaluation of future remnant liver function by the contrast enhanced ratio hepatocellular imaging (2011)
  • Author(s): 松島秀
  • Organizer: Radiological Society of North America 97nd Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2011-11-30
• [Presentation] Gd-EOB-DTPAを用いた残肝機能の術前評価 (2011)
  • Author(s): 松島秀, 佐藤洋造, 山浦秀和, 加藤弥菜,井上大作, 紀ノ定保臣, 惠良聖一, 高橋和也、稲葉吉隆
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: リーガロイヤルホテル小倉
  • Year and Date: 2011-09-30
• [Presentation] Evaluation of future remnant liver function by the contrast enhanced ratio in Hepatocellular imaging (2011)
  • Author(s): S. Matsushima, Y. Sato, H. Yamaura, M. Kato, Y. Kinosada, S. Era, H. Shimizu, Y Inaba
  • Organizer: Radiological Society of North America 97nd Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, USA
• [Presentation] Preoperative evaluation of future remnant liver function by the contrast enhance ratio in hepatocellular image (2011)
  • Author(s): S. Matsushima, Y. Sato, H. Yamaura, M. Kato, T. Kanamoto, Y. Kinosada, S. Era, H. Koyanagi, Y. Inaba
  • Organizer: 2011 European Congress of Radiology
  • Place of Presentation: Austria Center, Vienna, Austria
• [Presentation] Preoperative evaluation of future remnant liver function by the contrast enhance ratio in hepatocellular image. (2011)
  • Author(s): 松島秀
  • Organizer: 2011 European Congress of Radiology
  • Place of Presentation: Austria Center, Vienna, Austria
• [Presentation] The correlation between liver function and contrast enhanced ratio in the hepatocellular image. (2010)
  • Author(s): 松島秀
  • Organizer: Radiological Society of North America 96nd Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2010-11-29
• [Presentation] Gd-EOB-DTPAを用いた肝機能画像 (2010)
  • Author(s): 松島秀, 佐藤洋造, 山浦秀和, 惠良聖一, 紀ノ定保臣, 稲葉吉隆
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2010-10-02
• [Presentation] Gd-EOB-DTPAを用いた肝機能画像 (2010)
  • Author(s): 松島秀
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: つくば国際会議場(つくば市)
  • Year and Date: 2010-10-02
• [Presentation] New imaging tool for the post-radiated parotid gland function (2010)
  • Author(s): H. Shimizu, S. Matsushima, Y. Kinosada, H. Miyamura, T. Kodaira
  • Organizer: ASTRO'S 52nd Annual Meeting
  • Place of Presentation: San Diego Convention Center, San Diego
• [Presentation] Comparative 1H NMR studied of saturation transfer in copolymer gels and mouse lenses (2010)
  • Author(s): S.Era, M. Sogami, K. Nakamura, S. Matsushima, Y. Kinosada
  • Organizer: International Conference on Magnetic Resonance in Biological Systems
  • Place of Presentation: Cairns Queensland, Australia
• [Presentation] In vitro and in vivo characterization of polymer-water interaction studied by an off-resonance MRI- synthetic copolymer gels and breast carcinoma (2010)
  • Author(s): S. Era, S. Matsushima, M. Sogami and Y. Kinosada
  • Organizer: World Wide Magnetic Resonance Florence 2010
  • Place of Presentation: Florence, Itary
• [Presentation] The correlation between liver function and contrast enhanced ratio in the hepatocellular image
  • Author(s): S. Matsushima, Y. Sato, H. Yamaura, Y. Kinosada, S. Era, Y Inaba
  • Organizer: Radiological Society of North America 96nd Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, USA
• [Presentation] 細胞外マトリクスの造影効果を考慮したGd-EOB-DTPAの肝細胞相造影率画像
  • Author(s): 松島秀
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 国立京都国際会館(京都）
• [Presentation] Correlation of hepatocellular density and contrast enhance ratio in hepatocellular of the surrounding non-cancerous background liver tissue.
  • Author(s): S.Matsushima
  • Organizer: Radiological Society of North America 98nd Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place (Chicago)