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Protection from human normal tissue fibrosis induced by radiotherapy

Research Project

Project/Area Number 22591383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

HONGYO Tadashi  大阪大学, 医学系研究科, 准教授 (90271569)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Hiroo  大阪大学, 医学(系)研究科(研究院), 助教 (20237275)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords放射線による線維化 / 放射線治療の晩発性障害 / Sircol assay / Cystatin C assay / アスコルビン酸 / AHCC / 線維化抑制効果 / マッソン・トリクローム染色 / Cystatin-C assay / 放射線治療 / 放射線障害 / 線維化 / 抗線維化剤 / 毛の脱顆粒 / SCIDマウス / 移植
Research Abstract

Irradiation in radiation therapy or bone marrow transplantation is known to cause damage to normal tissues. Although some substances are reported to suppress the damage(=radioprotectors), most of them have strong side effects and are not applicable in vivo. However, ascorbic acid and AHCC (Active Hexose Correlated Compound) are known as safe radioprotectors with antioxidant activity. While examining some radioprotectors using mice, we found that ascorbic acid and AHCC suppress fibrosis of lung and kidney caused by irradiation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (10 results)

  • [Journal Article] Evaluation of Human Risk in Space Environment and Its Protection;Protection of Radiation Late Effects2012

    • Author(s)
      Nomura T, AdachiS, Ryo H, Hatanaka E, Kikuya R, Tokita Y,Horike N, Nakajima H, Hongyo T, Fujikawa K, Itoh T, Ochiai T, Gyotoku J, Wakame K,Parida DK, Bersimbay RI
    • Journal Title

      Space Utiliz Res

      Volume: 28 Pages: 126-129

    • Related Report
      2012 Final Research Report
  • [Journal Article] Evaluation of Human Risk in Space Environment and Its Protection;Protection of Radiation Late Effects.2012

    • Author(s)
      Taisei Nomura
    • Journal Title

      Space Utiliz Res.

      Volume: 28 Pages: 126-129

    • Related Report
      2012 Annual Research Report
  • [Journal Article] A rapid and easy method for the qualitative detection of intracellular deposition of inhaled nanoparticles2011

    • Author(s)
      H Nakajima, K Ozaki, T Hongyo, I Narama, T Todo
    • Journal Title

      Nanomedicine.

      Volume: 6 Pages: 881-888

    • Related Report
      2012 Final Research Report
  • [Journal Article] Evaluation of Human Risk in Space Environment and Its Protection2011

    • Author(s)
      T Nomura, H Ryo, S Adachi, Y Tokita, N Horike, E Hatanaka, R Kikuya, H Nakajima, T Hongyo, K Fujikawa, T Itoh, T Ochiai, J Gyotoku, K Wakame
    • Journal Title

      Space Utiliz Res

      Volume: 27 Pages: 107-110

    • NAID

      120006830344

    • Related Report
      2012 Final Research Report
  • [Journal Article] A rapid and easy method for the qualitative detection of intracellular Deposition of inhaled nanoparticles2011

    • Author(s)
      Nakajima H, Hongyo T, et al
    • Journal Title

      Nanomedicine

      Volume: 7 Pages: 881-888

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of fission neutrons on human thyroid tissues maintained in SCID mice2010

    • Author(s)
      Shigeki Adachi, Haruko Ryo, Tadashi Hongyo, Hiroo Nakajima, Rei Tsuboi-Kikuya, Yoriko Tokita, Fumio Matsuzuka, Keizo Hiramatsu, Kazuo Fujikawa, Tetsuo Itoh, and Taisei Nomura
    • Journal Title

      Mutation Research

      Volume: 696 Pages: 107-113

    • Related Report
      2012 Final Research Report
  • [Presentation] Ascorbic acid and AHCC suppress fibrosis of lung and kidney caused by irradiation.2012

    • Author(s)
      T Hongyo, H Nakajima.
    • Organizer
      39thAnnual Meeting of the European Radiation Research Society.
    • Place of Presentation
      Vietri sul Mare, Italy
    • Year and Date
      2012-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] アスコルビン酸および AHCC による放射線繊維化の抑制2012

    • Author(s)
      本行忠志、中島裕夫
    • Organizer
      第55回日本放射線影響学会
    • Place of Presentation
      仙台
    • Year and Date
      2012-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Prevention of Cancer and Radiation Induced Disorders by Active Hexose Correlated Compound, AHCC in Mice and Humans2012

    • Author(s)
      Taisei Nomura, Rie Kikuya, Shigeki Adachi, Haruko Ryo, Eiko Hatanaka, Momoyo Kaji, Koujun Yasuda, Hiroo Nakajima,Tadashi Hongyo, D. K. Parida
    • Organizer
      第20回総合医療機能性食品国際会議(ICNIM)
    • Place of Presentation
      北海道
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Ascorbic acid and AHCC suppress fibrosis of lung and kidney caused by irradiation2012

    • Author(s)
      Tadashi Hongyo
    • Organizer
      39th Annual Meeting of the European Radiation Research Society.
    • Place of Presentation
      Vietri sul Mare, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] アスコルビン酸およびAHCCによる放射線繊維化の抑制2012

    • Author(s)
      本行忠志
    • Organizer
      55回日本放射線影響学会
    • Place of Presentation
      仙台、日本
    • Related Report
      2012 Annual Research Report
  • [Presentation] 吸入暴露による細胞内ナノ粒子の迅速簡便同定検出法. A rapid and easy method for the qualitative detection of intracellular deposition of inhaled nanoparticles2011

    • Author(s)
      中島裕夫、尾崎清和、本行忠志、奈良間功、藤堂剛
    • Organizer
      日本環境変異原学会第40回大会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Ascorbic acid suppresses hair depigmentation caused by irradiation2011

    • Author(s)
      T Hongyo, H Nakajima, T Todo, T Nomura.
    • Organizer
      14th Int. Cong. Radiat. Res
    • Place of Presentation
      Warsow-Poland
    • Year and Date
      2011-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] In vivo distribution of radionuclides, tumorigenicity and genome stress in mice after Chernobyl catastrophe2011

    • Author(s)
      H Nakajima, TSaito, T Hongyo, H Ryo, T Todo, T Nomura.
    • Organizer
      14th Int. Cong. Radiat. Res.(ICRR)
    • Place of Presentation
      Warsow-Poland
    • Year and Date
      2011-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Ascorbic acid suppresses hair depigmentation caused by irradiation2011

    • Author(s)
      Hongyo T, Nakajima H, et al
    • Organizer
      14^<th> International Congress of Radiation Research
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 宇宙環境の人体影響評価2010

    • Author(s)
      野村大成、梁治子、足立成基、大平充宣、本行忠志、中島裕夫、伊藤 哲夫、 藤川和男、落合俊昌、行徳淳一郎、桂 洋介、時田偉子、堀家なな緒
    • Organizer
      宇宙利用シンポジウム(第26回)
    • Place of Presentation
      宇宙航空研究開発機構・相模原キャンパス(相模原)、
    • Year and Date
      2010-01-26
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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