Protection from human normal tissue fibrosis induced by radiotherapy

• Project/Area Number: 22591383
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: HONGYO Tadashi 大阪大学, 医学系研究科, 准教授 (90271569)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Hiroo 大阪大学, 医学(系)研究科(研究院), 助教 (20237275)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線による線維化 / 放射線治療の晩発性障害 / Sircol assay / Cystatin C assay / アスコルビン酸 / AHCC / 線維化抑制効果 / マッソン・トリクローム染色 / Cystatin-C assay / 放射線治療 / 放射線障害 / 線維化 / 抗線維化剤 / 毛の脱顆粒 / SCIDマウス / 移植

Research Abstract

Irradiation in radiation therapy or bone marrow transplantation is known to cause damage to normal tissues. Although some substances are reported to suppress the damage(=radioprotectors), most of them have strong side effects and are not applicable in vivo. However, ascorbic acid and AHCC (Active Hexose Correlated Compound) are known as safe radioprotectors with antioxidant activity. While examining some radioprotectors using mice, we found that ascorbic acid and AHCC suppress fibrosis of lung and kidney caused by irradiation.

Research Products

• [Journal Article] Evaluation of Human Risk in Space Environment and Its Protection;Protection of Radiation Late Effects (2012)
  • Author(s): Nomura T, AdachiS, Ryo H, Hatanaka E, Kikuya R, Tokita Y,Horike N, Nakajima H, Hongyo T, Fujikawa K, Itoh T, Ochiai T, Gyotoku J, Wakame K,Parida DK, Bersimbay RI
  • Journal Title: Space Utiliz Res Volume: 28 Pages: 126-129
• [Journal Article] Evaluation of Human Risk in Space Environment and Its Protection；Protection of Radiation Late Effects. (2012)
  • Author(s): Taisei Nomura
  • Journal Title: Space Utiliz Res. Volume: 28 Pages: 126-129
• [Journal Article] A rapid and easy method for the qualitative detection of intracellular deposition of inhaled nanoparticles (2011)
  • Author(s): H Nakajima, K Ozaki, T Hongyo, I Narama, T Todo
  • Journal Title: Nanomedicine. Volume: 6 Pages: 881-888
• [Journal Article] Evaluation of Human Risk in Space Environment and Its Protection (2011)
  • Author(s): T Nomura, H Ryo, S Adachi, Y Tokita, N Horike, E Hatanaka, R Kikuya, H Nakajima, T Hongyo, K Fujikawa, T Itoh, T Ochiai, J Gyotoku, K Wakame
  • Journal Title: Space Utiliz Res Volume: 27 Pages: 107-110
  • NAID: 120006830344
• [Journal Article] A rapid and easy method for the qualitative detection of intracellular Deposition of inhaled nanoparticles (2011)
  • Author(s): Nakajima H, Hongyo T, et al
  • Journal Title: Nanomedicine Volume: 7 Pages: 881-888
  • Peer Reviewed
• [Journal Article] Effects of fission neutrons on human thyroid tissues maintained in SCID mice (2010)
  • Author(s): Shigeki Adachi, Haruko Ryo, Tadashi Hongyo, Hiroo Nakajima, Rei Tsuboi-Kikuya, Yoriko Tokita, Fumio Matsuzuka, Keizo Hiramatsu, Kazuo Fujikawa, Tetsuo Itoh, and Taisei Nomura
  • Journal Title: Mutation Research Volume: 696 Pages: 107-113
• [Presentation] Ascorbic acid and AHCC suppress fibrosis of lung and kidney caused by irradiation. (2012)
  • Author(s): T Hongyo, H Nakajima.
  • Organizer: 39thAnnual Meeting of the European Radiation Research Society.
  • Place of Presentation: Vietri sul Mare, Italy
  • Year and Date: 2012-10-19
• [Presentation] アスコルビン酸および AHCC による放射線繊維化の抑制 (2012)
  • Author(s): 本行忠志、中島裕夫
  • Organizer: 第55回日本放射線影響学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-09-08
• [Presentation] Prevention of Cancer and Radiation Induced Disorders by Active Hexose Correlated Compound, AHCC in Mice and Humans (2012)
  • Author(s): Taisei Nomura, Rie Kikuya, Shigeki Adachi, Haruko Ryo, Eiko Hatanaka, Momoyo Kaji, Koujun Yasuda, Hiroo Nakajima,Tadashi Hongyo, D. K. Parida
  • Organizer: 第20回総合医療機能性食品国際会議(ICNIM)
  • Place of Presentation: 北海道
  • Year and Date: 2012-07-21
• [Presentation] Ascorbic acid and AHCC suppress fibrosis of lung and kidney caused by irradiation (2012)
  • Author(s): Tadashi Hongyo
  • Organizer: 39th Annual Meeting of the European Radiation Research Society.
  • Place of Presentation: Vietri sul Mare, Italy
• [Presentation] アスコルビン酸およびAHCCによる放射線繊維化の抑制 (2012)
  • Author(s): 本行忠志
  • Organizer: 55回日本放射線影響学会
  • Place of Presentation: 仙台、日本
• [Presentation] 吸入暴露による細胞内ナノ粒子の迅速簡便同定検出法. A rapid and easy method for the qualitative detection of intracellular deposition of inhaled nanoparticles (2011)
  • Author(s): 中島裕夫、尾崎清和、本行忠志、奈良間功、藤堂剛
  • Organizer: 日本環境変異原学会第40回大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-22
• [Presentation] Ascorbic acid suppresses hair depigmentation caused by irradiation (2011)
  • Author(s): T Hongyo, H Nakajima, T Todo, T Nomura.
  • Organizer: 14th Int. Cong. Radiat. Res
  • Place of Presentation: Warsow-Poland
  • Year and Date: 2011-09-01
• [Presentation] In vivo distribution of radionuclides, tumorigenicity and genome stress in mice after Chernobyl catastrophe (2011)
  • Author(s): H Nakajima, TSaito, T Hongyo, H Ryo, T Todo, T Nomura.
  • Organizer: 14th Int. Cong. Radiat. Res.(ICRR)
  • Place of Presentation: Warsow-Poland
  • Year and Date: 2011-09-01
• [Presentation] Ascorbic acid suppresses hair depigmentation caused by irradiation (2011)
  • Author(s): Hongyo T, Nakajima H, et al
  • Organizer: 14^<th> International Congress of Radiation Research
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2011-08-31
• [Presentation] 宇宙環境の人体影響評価 (2010)
  • Author(s): 野村大成、梁治子、足立成基、大平充宣、本行忠志、中島裕夫、伊藤 哲夫、 藤川和男、落合俊昌、行徳淳一郎、桂 洋介、時田偉子、堀家なな緒
  • Organizer: 宇宙利用シンポジウム(第26回)
  • Place of Presentation: 宇宙航空研究開発機構・相模原キャンパス(相模原)、
  • Year and Date: 2010-01-26