| Project/Area Number |
22591409
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
INOMATA Yukihiro 熊本大学, 大学院・生命科学研究部, 教授 (50193628)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ASONUMA Katsuhiro 熊本大学, 医学部附属病院移植医療学寄付講座, 教授 (40202626)
|
|---|
| Research Collaborator |
HAYASHIDA Sinntarou 熊本大学, 医学部附属病院, 医員
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 肝移植 / 抗ドナー抗体 / HLA / LAB Screen 法 / 液性免疫 / 生体肝移植 |
|---|
| Research Abstract |
Anti-HLA antibody (a-HLA Ab) and donor specific antibody (DSA) in recipients were measuredbefore and after the living donor liver transplantation (LDLT), using LAB Screen singleantigen examination. Both titers of a-HLA Ab and DSA did not show significant correlationwith the post-transplant survival. Prevalence of post-transplant DSA was 0% in classI and 15% in class II. This study showed the dynamics of anti-donor antibody in LDLT,and presented the basic data for the research of antibody-mediated immunoreaction in livertransplantation.
|
