Application of Serum Antibodies against c-myc to Malignant Solid Tumors

• Project/Area Number: 22591416
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Toho University
• Principal Investigator: YAMAZAKI Kunihiro 東邦大学, 医学部, 客員講師 (00307761)
• Co-Investigator(Kenkyū-buntansha): SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: SEREX / serum antibody / c-myc / malignant tumor / VEGF / p53 / ELISA / 固形癌 / 血清抗体 / 腫瘍マーカー

Research Abstract

Purpose of this study was (i) establish ELISA system to detect serum anti-c-myc antibodies, and (ii) evaluate positive rate of serum anti-c-myc antibodies in patients with malignant solid tumors. Using a cut-off value of mean +3SD of serum anti-c-myc antibody level of healthy controls, positive rate of patients were evaluated. Various kind of serum samples from stage I or stage II cancer patients were analyzed for serum c-myc antibodies. The positive rates were prostae cancer=8%, lung cancer=9%, gastric cancer=14%, colon cancer=6%, breastcancer=13%, esophageal cancer=12%, liver cancer=10%, respectively. No clinicopathological factors were associated with presence of anti-c-myc antibodies. Plural serum antibodiescan increase sensitivity to detect cancer.

Research Products

• [Journal Article] SAP155-mediated c-myc suppressor FBP-interacting repressor splicing variants are activated in colon cancer tissues (2013)
  • Author(s): Kajiwara T, Matsushita K, Itoga S, Tamura M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Habara Y, Matsuo M, Nomura F
  • Journal Title: Cancer Sci Volume: 104(2) Issue: 2 Pages: 149-156
  • DOI: 10.1111/cas.12058
  • Peer Reviewed
• [Journal Article] Impact of serum biomarkers on esophageal squamous cell carcinoma (2012)
  • Author(s): Shimada H, Yajima S, Oshima Y, Hiwasa T, Tagawa M, Matsushita K, Nomura F
  • Journal Title: Esophagus Volume: 9(3) Issue: 3 Pages: 131-140
  • DOI: 10.1007/s10388-012-0332-x
  • NAID: 40019427695
  • Peer Reviewed
• [Journal Article] SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression (2012)
  • Author(s): Matsushita, K., Kajiwara, T., Tamura, M., Satoh, M., Tanaka, N., Tomonaga, T., Matsubara, H., Shimada, H., Yoshimoto, R., Ito, A., Kubo, S., Natsume, T., Levens, D., Yoshida, M., and Nomura, F
  • Journal Title: Mol. Cancer Res Volume: 10 Issue: 6 Pages: 787-799
  • DOI: 10.1158/1541-7786.mcr-11-0462
  • Peer Reviewed
• [Journal Article] Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed (2012)
  • Author(s): Li, Q., Kawamura, K., Okamoto, S., Yamanaka, M., Yang, S., Yamauchi, S., Fukamachi, T., Kobayashi, H., Tada, Y., Takiguchi, Y., Tatsumi, K., Shimada, H., Hiroshima, K. and Tagawa, M.
  • Journal Title: Cancer Gene Ther Volume: 19 Issue: 3 Pages: 218-228
  • DOI: 10.1038/cgt.2011.86
  • Peer Reviewed
• [Journal Article] Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells (2011)
  • Author(s): Tonoike Y, Matsushita K…, Shimada H, et al.(6番目/9人中)
  • Journal Title: BMC cell biology Volume: 12(1) Issue: 1 Pages: 41-41
  • DOI: 10.1186/1471-2121-12-41
  • Peer Reviewed
• [Journal Article] Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in treatment of malignant pleural mesothelioma (2011)
  • Author(s): Kitamura A, Matsushita K, Takiguchi Y, Shimada H, Tada Y, Yamanaka M, Hiroshima K, Tagawa M, Tomonaga T, Matsubara H, Inoue M, Hasegawa M, Sato Y, Levens D, Tatsumi K, Nomura F
  • Journal Title: Cancer Sci Volume: 102 Issue: 7 Pages: 1366-73
  • DOI: 10.1111/j.1349-7006.2011.01931.x
  • NAID: 10029295478
  • Peer Reviewed
• [Journal Article] 食道癌におけるバイオマーカー血液バイオマーカーの有用性について (2011)
  • Author(s): 谷島聡, 山崎有浩, 島田英昭
  • Journal Title: 消化器外科 Volume: 34(13) Pages: 1889-1895
• [Journal Article] p53抗体はどのくらい役に立つか? (2011)
  • Author(s): 谷島聡, 山崎有浩, 島田英昭, 他2名
  • Journal Title: 成人病と生活習慣病 Volume: 41(6) Pages: 750-752
• [Journal Article] Angiogenesis-related factors are molecular targets for diagnosis and treatment patients with esophageal carcinoma. (2010)
  • Author(s): Oshima Y, Yajima S, Yamazaki K, Matsushita K, Tagawa M, Shimada H
  • Journal Title: Ann Thorac Cardiovasc Surg Volume: 16(6) Pages: 389-393
  • NAID: 10029685984
  • Peer Reviewed
• [Journal Article] 腫瘍マーカー 血清p53抗体-診断モニタリング- (2010)
  • Author(s): 島田英昭, 山崎有浩, 谷島聡, 大嶋陽幸, 小池淳一
  • Journal Title: 日本臨床 Volume: 68(Suppl7) Pages: 829-832
  • Peer Reviewed
• [Presentation] 食道扁平上皮癌の血液バイオマーカーの開発 (2012)
  • Author(s): 島田英昭
  • Organizer: 第64回日本気管食道科学会総会ならびに学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-09
• [Presentation] 癌診療におけるp53抗体マーカーの有用性～PUBMED文献から～ (2011)
  • Author(s): 島田英昭、山崎有浩
  • Organizer: 第73回日本臨床外科学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-11-17
• [Presentation] Clinical utility of serum p53 antibody for patients with esophageal carcinoma (2011)
  • Author(s): Shimada H, Yamazaki K
  • Organizer: 21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO2011)
  • Place of Presentation: Keio Plaza Hotel, Tokyo
  • Year and Date: 2011-11-12
• [Presentation] 島田英昭, 谷島 聡, 小池淳一, 田川雅敏, 竹田明彦, 松下一之, 日和佐隆樹, 野村文夫 (2011)
  • Author(s): 島田英昭, 谷島 聡, 小池淳一, 田川雅敏, 竹田明彦, 松下一之, 日和佐隆樹, 野村文夫
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] 消化器癌症例における血清SEREX抗体の検出～新しいバイオマーカー検査法開発を目指して～ (2011)
  • Author(s): 谷島 聡, 島田英昭, 山崎有浩, 大嶋陽幸, 鈴木 隆, 名波竜規, 石井 淳, 大塚由一郎, 鷲澤尚宏, 金子弘真
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-14
• [Presentation] 消化管癌症例における血清中抗Heat Shock Protein 70 IgG抗体の検出 (2011)
  • Author(s): 山崎有浩, 島田英昭
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: (紙上開催)
  • Year and Date: 2011-05-26
• [Presentation] Serum SEREX antibodies as new biomarkers for gastric cancer (2011)
  • Author(s): Shimada H, Ya ma za ki K, Yajima S, Oshima Y, Nanami T, Tamura A, Kaneko H
  • Organizer: 9th International Gastric Cancer Congress Seoul
  • Place of Presentation: Korea
  • Year and Date: 2011-04-21
• [Presentation] Serum SEREX antibodies as new biomarkers for gastric cancer (2011)
  • Author(s): Shimada H, Yamazaki K
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-21
• [Presentation] Serum SEREX antibodies as new biomarkers for stage I/II gastric cancer. (2010)
  • Author(s): Shimada H, Yamazaki K, Yajima S, Ooshima Y, Nanami T, Tamura A, Tsuchiya M, Maeda T, Suzuki T, Ootsuka Y, Kaneko H
  • Organizer: The 7th International Symposium on Cancer Research and Therapy
  • Place of Presentation: 東京會舘(東京都)
  • Year and Date: 2010-11-27
• [Presentation] Serum IgG antibodies as new tumor markers for esophageal carcinoma. (2010)
  • Author(s): Shimada H, Yajima S, Yamazaki K, Oshima Y, Kaneko H
  • Organizer: 12th World Congress of the International Society for Diseases of the Esophagus
  • Place of Presentation: 城山観光ホテル(鹿児島県)
  • Year and Date: 2010-09-05
• [Presentation] 食道扁平上皮癌の血液バイオマーカーの開発.
  • Author(s): 島田英昭
  • Organizer: 第64回日本気管食道科学会総会ならびに学術講演会
  • Place of Presentation: ホテル日航東京（東京都）