Role of prevascularization of islets in the induction of tolerance of allogeneic islets in miniature swine
| Project/Area Number |
22591417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kazuhiko 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (40241103)
SASHARA Hisashi 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 特任准教授 (90452333)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Akira 日本医科大学, 医学部, 准教授 (00256942)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 移植外科学 / 膵島移植 / 移植後免疫寛容 / ミニブタ / 腎移植 / 膵島・腎移植 / 血管再構築 / 移植・再生医療 / トランスレーショナルリサーチ / 免疫寛容 |
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| Research Abstract |
We have previously reported successful induction of tolerance of allogeneic islets by transplantation of islets as a form of composite islet-kidney in preclinical MHC inbred miniature swine while all islets were rejected when islets were injected as islet cell transplantation. This study aimed to determine whether vascularized islets have the ability to induce tolerance without renal graft.
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Report
(4 results)
Research Products
(8 results)
