Role of prevascularization of islets in the induction of tolerance of allogeneic islets in miniature swine

• Project/Area Number: 22591417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nippon Medical School
• Principal Investigator: HIRAKATA Atsushi 日本医科大学, 医学部, 助教 (40468765)
• Co-Investigator(Kenkyū-buntansha): YAMADA Kazuhiko 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (40241103) ; SASHARA Hisashi 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 特任准教授 (90452333)
• Co-Investigator(Renkei-kenkyūsha): SHIMIZU Akira 日本医科大学, 医学部, 准教授 (00256942)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 移植外科学 / 膵島移植 / 移植後免疫寛容 / ミニブタ / 腎移植 / 膵島・腎移植 / 血管再構築 / 移植・再生医療 / トランスレーショナルリサーチ / 免疫寛容

Research Abstract

We have previously reported successful induction of tolerance of allogeneic islets by transplantation of islets as a form of composite islet-kidney in preclinical MHC inbred miniature swine while all islets were rejected when islets were injected as islet cell transplantation. This study aimed to determine whether vascularized islets have the ability to induce tolerance without renal graft.

Research Products

• [Journal Article] The induction of tolerance of renal allografts by adoptive transfer in miniature Swine. (2013)
  • Author(s): Okumi M, Hirakata A, Yamada K
  • Journal Title: Am J Transplant. Volume: 13(5) Pages: 1193-202
• [Journal Article] The induction of tolerance of renal allografts by adoptive transfer in miniature Swine (2013)
  • Author(s): Okumi M, Scalea JR, Gillon BC, Tasaki M, Villani V, Cormack T, Hirakata A, Shimizu A, Sachs DH, Yamada K.
  • Journal Title: American Journal of Transplantation Volume: 13 Issue: 5 Pages: 1193-1202
  • DOI: 10.1111/ajt.12194
  • Peer Reviewed
• [Journal Article] Composite islet-kidneys from single baboon donors cure diabetes across fully allogenic barriers. (2011)
  • Author(s): Yamada K and Hirakata A
  • Journal Title: Am J Transplant. Volume: 11(12) Pages: 2603-12
• [Journal Article] Composite islet-kidneys from single baboon donors cure diabetes acrossfully allogenic barriers (2011)
  • Author(s): Yamada K, Hirakata A, Tchipashvili V, Shimizu A, Iwaki H, et al
  • Journal Title: American Journal of Transplantation Volume: 11 Pages: 2603-2612
  • Peer Reviewed
• [Journal Article] Reversal of age-related thymic involution by an LHRH agonist in miniature swine. (2010)
  • Author(s): Hirakata A and Yamada K
  • Journal Title: Transpl Immunol. Volume: 24(1) Pages: 76-81
• [Journal Article] Reversal of age-related thymic involution by an LHRH agonist in miniature swine. (2010)
  • Author(s): Hirakata A, Nobori S, YamadaK, et al.
  • Journal Title: Transpl Immunol Volume: 24 Pages: 76-81
  • Peer Reviewed
• [Presentation] SOTA 6- Barriers to vascularized xenotransplantation solid organ Xenotransplantation: Overcome cellular immune responses. (2011)
  • Author(s): Yamada K.
  • Organizer: CTS (Cell Transplant Society) -IXA (International Xenotransplantation Association) 2011 Joint Congress.
  • Place of Presentation: Miami beach, FL, US.
• [Presentation] ワークショップ3.膵・膵島移植の現状と今後の課題」血管再構築と免疫寛容誘導戦略に基づく重症糖尿病性腎症根治療法の確立 (2010)
  • Author(s): 山田和彦
  • Organizer: 第46回日本移植学会総会
  • Place of Presentation: 京都市