| Project/Area Number |
22591418
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | National Research Institute for Child Health and Development (2011-2012)
Fujita Health University (2010) |
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Principal Investigator |
MORITA Miwa 独立行政法人国立成育医療研究センター, RI管理室, 共同研究員 (90329699)
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| Co-Investigator(Kenkyū-buntansha) |
RII Kou (独)国立成育医療センター, RI管理室, 室長 (60321890)
SUGIOKA Atsushi 藤田保健衛生大学, 医学部, 教授 (20171150)
長尾 静子 藤田保健衛生大学, 大学共同利用機関等の部局等, 准教授 (20183527)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 移植免疫 / 免疫寛容 / マウス同所性肝移植モデル / マイクロRNA / 骨髄由来免疫抑制細胞 / MDSC / マウス肝移植モデル / 移植・再生医療 / microRNA / co-stimulatory signal / PD-1/PD-L1シグナル |
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| Research Abstract |
For the development of novel imunosuppression in organ transplantation, we have analyzed the mechanism of graft acceptance using orthotopic mouse liver transplantation, which can induce immunological tolerance without immunosuppressive drugs. It shows that one of the co-stimulatory molecule, PD-1/PD-L1 pathway is essential for graft acceptance. And it has analyzed that microRNA which associated with rejection or acceptance of allografts. And it suggested that myeloid-derived suppressor cells has an important role for inhibition for graft rejection.
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