The clarify of the mechanism of induction of immunological tolerance using mouse liver transplantation model and development of novel immunosuppression.

• Project/Area Number: 22591418
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: National Research Institute for Child Health and Development (2011-2012); Fujita Health University (2010)
• Principal Investigator: MORITA Miwa 独立行政法人国立成育医療研究センター, RI管理室, 共同研究員 (90329699)
• Co-Investigator(Kenkyū-buntansha): RII Kou (独)国立成育医療センター, RI管理室, 室長 (60321890) ; SUGIOKA Atsushi 藤田保健衛生大学, 医学部, 教授 (20171150) ; 長尾 静子 藤田保健衛生大学, 大学共同利用機関等の部局等, 准教授 (20183527)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 移植免疫 / 免疫寛容 / マウス同所性肝移植モデル / マイクロRNA / 骨髄由来免疫抑制細胞 / MDSC / マウス肝移植モデル / 移植・再生医療 / microRNA / co-stimulatory signal / PD-1/PD-L1シグナル

Research Abstract

For the development of novel imunosuppression in organ transplantation, we have analyzed the mechanism of graft acceptance using orthotopic mouse liver transplantation, which can induce immunological tolerance without immunosuppressive drugs. It shows that one of the co-stimulatory molecule, PD-1/PD-L1 pathway is essential for graft acceptance. And it has analyzed that microRNA which associated with rejection or acceptance of allografts. And it suggested that myeloid-derived suppressor cells has an important role for inhibition for graft rejection.

Research Products

• [Journal Article] Identification of a novel biomarker gene set with sensitivity and specificity to distinguish between allograft rejection and tolerance (2012)
  • Author(s): Xie L, et al
  • Journal Title: Liver Transplant Volume: 18 Pages: 444-454
  • Peer Reviewed
• [Journal Article] Deletion of CD98hc in T cells results in cardiac allograft acceptance by increasing regulatory T cells
  • Author(s): Liu Z, et al
  • Journal Title: Transplantation Volume: (掲載決定)
  • Peer Reviewed
• [Journal Article] Bone marrow derived conventional, but not cloned, mesenchymal stem cells suppress lymphocyte proliferation and prevent graft-versus-host disease in rats
  • Author(s): Kitazawa Y, et al
  • Journal Title: Cell Transplant Volume: (In press)
• [Presentation] ドナー造血幹細胞移植後のキメラ構築による特異的臓器移植免疫寛容の誘導 (2012)
  • Author(s): 劉馳
  • Organizer: 第39回日本臓器保存生物医学会
  • Place of Presentation: 福島
  • Year and Date: 2012-11-16
• [Presentation] To induce mixed chimerism and specific transplantation immune tolerance via donor hematopoietic stem cells. (2012)
  • Author(s): Liu C
  • Organizer: The 3^<rd> International Conference on Regulatory T cells and Helper T cell Subsets and Clinical Application Human Diseases
  • Place of Presentation: Shanghai, China
  • Year and Date: 2012-10-12
• [Presentation] マウス肝移植モデルを用いた免疫寛容誘導機序の解明 (2012)
  • Author(s): 李小康
  • Organizer: 日本移植学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] マウス肝移植モデルを用いた免疫寛容機序の解明. (2012)
  • Author(s): 李小康
  • Organizer: 第48回日本移植学会総会
  • Place of Presentation: 名古屋
• [Presentation] To induce mixed chimerism and specific transplantation immune tolerance via donor hematopoietic stem cells. (2012)
  • Author(s): Liu C
  • Organizer: The 3rd International Conference on Regulatory T Cells and Helper T Cell Subsets and Clinical Application in Human Diseases
  • Place of Presentation: Shanghai, China
• [Presentation] ドナー造血幹細胞移植後のキメラ構築による特異的臓器移植免疫寛容の誘導. (2012)
  • Author(s): 劉馳
  • Organizer: 第39回日本臓器保存生物医学会
  • Place of Presentation: 福島
• [Presentation] (2011)
  • Author(s): Songjie Cai
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 幕張
• [Presentation] Noninvasive imaging with 18F-FDG in rat liver transplantation (2010)
  • Author(s): Morita. M
  • Organizer: XXIII international congress of The Transplantation Society
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-08-16