| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Cisplatin given intravenously produced abnormal motor activity that lasted up to 5 hours. 5HT3 receptor antagonist inhibited cisplatin induced an abnormal motor activity, but Rikkunshito did not inhibit it. The 5-HT concentration in plasma reached a peak at 4 hours after cisplatin administration. In a fasting state, intragastric administration of rikkunshito induced phasic contractions in the duodenum and jejunum in normal dogs. Rikkunshito-induced contractions were inhibited by atropine and hexamethonium. Gastric emptying was accelerated by intragastric administration of rikkunshito in a dose-dependent manner. The plasma acylated ghrelin level 150 min after intragastric administration of4.0 g of rikkunshito was significantly higher than the control value. These findings indicate that the contractile effect of rikkunshito is mediated by cholinergic neurons and that 5-HT3 receptors have apartial role in this action.
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