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Effect of traditional Japanese medicine (Kampo) to cisplatin induced abnormal digestive contractions -Rikkunshito and ghrelin-

Research Project

Project/Area Number 22591449
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionGunma University

Principal Investigator

MOCHIKI Erito  群馬大学, 医学部, 講師 (80312883)

Co-Investigator(Kenkyū-buntansha) OHNO Tetsuro  群馬大学, 大学院・医学系研究科, 助教 (60451712)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsシスプラチン / 消化管運動 / 嘔気 / 嘔吐 / 六君子湯 / 漢方 / グレリン / 副作用 / 胃排出 / 空腹期収縮
Research Abstract

Cisplatin given intravenously produced abnormal motor activity that lasted up to 5 hours. 5HT3 receptor antagonist inhibited cisplatin induced an abnormal motor activity, but Rikkunshito did not inhibit it. The 5-HT concentration in plasma reached a peak at 4 hours after cisplatin administration. In a fasting state, intragastric administration of rikkunshito induced phasic contractions in the duodenum and jejunum in normal dogs. Rikkunshito-induced contractions were inhibited by atropine and hexamethonium. Gastric emptying was accelerated by intragastric administration of rikkunshito in a dose-dependent manner. The plasma acylated ghrelin level 150 min after intragastric administration of4.0 g of rikkunshito was significantly higher than the control value. These findings indicate that the contractile effect of rikkunshito is mediated by cholinergic neurons and that 5-HT3 receptors have apartial role in this action.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (19 results)

All 2013 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (8 results)

  • [Journal Article] Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs.2013

    • Author(s)
      Mituhiro Yanai
    • Journal Title

      Journal of Gastroenterology

      Volume: in press Issue: 5 Pages: 611-619

    • DOI

      10.1007/s00535-012-0687-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs2012

    • Author(s)
      Yanai M, Mochiki E, Kuwano H.
    • Journal Title

      J Gastroenterol.J Gastroenterol

      Volume: 48(5) Pages: 611-619

    • NAID

      10031177012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rikkunshito, a Traditional Japanese Medicine, Suppresses Cisplatin-Induced Anorexia in Humans2011

    • Author(s)
      Ohno T, Yanai M, Ando H, Toyomasu Y, Ogawa A, Morita H, Ogata K, Mochiki E, Asao T, Kuwano H
    • Journal Title

      ClinExp Gastroenterol

      Volume: 4 Pages: 291-296

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 漢方による消化器疾患治療のポイントー消化器術後障害-2011

    • Author(s)
      持木彫人、矢内充洋、桑野博行
    • Journal Title

      消化器の臨床

      Volume: 14(3) Pages: 302-308

    • Related Report
      2012 Final Research Report
  • [Journal Article] 漢方による消化器疾患治療のポイントー消化器術後障害-2011

    • Author(s)
      持木彫人、桑野博行
    • Journal Title

      消化器の臨床

      Volume: 14 Pages: 302-308

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Rikkunshito, a traditional Japanese medicine, suppresses cisplatin-induced anorexonal in humans2011

    • Author(s)
      Ohno T, Mochiki E, Kuwano H
    • Journal Title

      Clin Exp Gastroenterol

      Volume: 4 Pages: 291-296

    • DOI

      10.2147/ceg.s26297

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] モチリンと関連疾患2011

    • Author(s)
      持木彫人、桑野博行
    • Journal Title

      医薬ジャーナル

      Volume: 47 Pages: 87-92

    • Related Report
      2011 Annual Research Report
  • [Journal Article] The effect of traditional Japanese medicine (Kampo) on gastrointestinal function2010

    • Author(s)
      Mochiki E, Yanai M, Ohno T, Kuwano H
    • Journal Title

      Surg Today

      Volume: 40(12) Pages: 1105-11

    • NAID

      10027657264

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗がん剤治療の副作用に対する漢方 治療、特集 外科臨床に必要な漢方治療 の知識2010

    • Author(s)
      持 木彫人 、小川敦、矢内充洋、豊増嘉高、緒方杏一、安藤裕之、大野哲郎、桑野博 行
    • Journal Title

      外科治療

      Volume: 103(6) Pages: 590-596

    • Related Report
      2012 Final Research Report
  • [Journal Article] 抗がん剤治療の副作用に対する漢方治療2010

    • Author(s)
      持木彫人、桑野博行
    • Journal Title

      外科治療

      Volume: 103 Pages: 590-596

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 消化管運動と漢方、特集消化器疾患と漢方2010

    • Author(s)
      持木彫人、桑野博行
    • Journal Title

      G.I.research

      Volume: 18 Pages: 276-282

    • Related Report
      2010 Annual Research Report
  • [Presentation] シスプラチン投与後の消化管運動と嘔吐2012

    • Author(s)
      矢内充洋、森田廣樹、小川敦、緒方杏一、大野哲郎、持木彫人、桑野博行
    • Organizer
      第54回日本平滑筋学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-02
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 六君子湯の消化管運動に対する作用2012

    • Author(s)
      矢内充洋、森田廣樹、小川敦、緒方杏一、大野哲郎、持木彫人、桑野博行
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 「ワークショップ上部消化器症状と漢方」六君子湯の上部消化管運動に対する作用2012

    • Author(s)
      矢内充洋、森田廣樹、小川敦、緒方杏一、大野哲郎、持木彫人、桑野博行
    • Organizer
      第8回日本消化管学会総会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2012-02-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 「シンポジウム29がん化学療法副作用対策としての漢方療法」抗癌剤治療における六君子湯の有用性-消化管機能の基礎的研究-2010

    • Author(s)
      持木彫人、矢内光洋、小川敦、森田廣樹、豊増嘉高、大野哲郎、桑野博行
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗癌剤治療における六君子湯の有用性-消化管機能の基礎的研究2010

    • Author(s)
      時木彫人、矢内充洋、桑野博行
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「シンポジウムII神経消化器病学と漢方-六君子湯とモティリティを中心に-」消化管機能に対する六君子湯の作用-vivoにおける基礎的検討-2010

    • Author(s)
      持木彫人、矢内充洋、小川敦、森田廣樹、豊増嘉高、大野哲郎、桑野博行
    • Organizer
      第12回日本神経消化器病学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 「ワークショップ8消化器外科領域における漢方の役割」六君子湯の消化管運動に対する作用2010

    • Author(s)
      矢内充洋、小川敦、森田廣樹、豊増嘉高、緒方杏一、田部雄一、安藤裕之、大野哲郎、持木彫人、桑野博行
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 「ワークショップ腹部救急診療における漢方の役割」抗癌剤による嘔吐に対する六君子湯の効果2010

    • Author(s)
      矢内充洋、小川敦、森田廣樹、豊増嘉高、緒方杏一、田部雄一、安藤裕之、大野哲郎、持木彫人、桑野博行
    • Organizer
      第46回日本腹部救急医学会総会
    • Place of Presentation
      富山
    • Year and Date
      2010-03-19
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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