Innovative treatment strategy for intractable gastroenterological cancer by control of DNA double strand repair pathway
| Project/Area Number |
22591457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University (2011-2012)
Department of Clinical Research, National Hospital Organization National Kyushu Cancer Center (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKEJI Yoshihiro 神戸大学, 医学部, 教授 (80284488)
MORITA Masaru 九州大学, 大学病院, 講師 (30294937)
YOSHINAGA Keiji 九州大学, 大学病院, 特任助教 (90507790)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 食道外科 / 食道癌 / DNA2重鎖切断修復 / DNA損傷 / 放射線照射 / 抗癌剤感受性 / loss of heterozygosity / SNP-CGH / コピーニュートラルLOH / 染色体不安定性 / 発癌 / 癌抑制遺伝子 / p53 / LOH / 遺伝子変異 / DNA2重鎖切断 |
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| Research Abstract |
Patients and Method. 1) One hundred sixty-eight patients with clinical Stage II-III (cStageII-III) ESCC were classified into two groups consisting of 76 who received NACRT followed by esophagectomy and 92 patients who received surgery alone. The prognosis and incidence of postoperative complications were retrospectively compared between the two groups. The pathological response to NACRT as well as the patientprognosis were also analyzed for the NACRT group patients. 2) The expression of Rad51 was investigated in pretreatment biopsy specimens in 41 ESCC cases who underwent surgery after NACRT, and the findings were compared with the pathological response to NACRT. Results. 1) The 5-year survival rate was 47.7% in the surgery alone group and 56.5% in the NACRT group, and the difference was not a statistically 機関番号：17102研究種目：基盤研究（Ｃ）研究期間：2010～2012課題番号：22591457研究課題名（和文） DNA2重鎖切断修復機構の制御による難治性消化器癌に対する革新的治療戦略研究課題名（英文） Innovative treatment strategy for intractable gastroenterological cancer by control of DNA double strand repair pathway研究代表者佐伯 浩司（SAEKI HIROSHI）九州大学・大学病院・助教研究者番号：80325448significant (P=0.4831). However, the 5-year survival rates of patients in whom NACRT was Grade 3 (markedly effective), was obviously better than that of the other patients (Grade0/1 - ineffective/slightly effective: 36.9%, Grade 2 - moderately effective: 53.8%, Grade 3 - markedly effective: 100%). The incidence of postoperative complications was 31.5% in the surgery alone group and 40.8% in the NACRT group, and the difference was not a statistically significant (P=0.2121). 2) Grade 3 was more frequently observed in Rad51-negative cases (n=13) than Rad51-positive cases (n=28; 71.4% vs. 28.6%, P=0.0239). Conclusions. The pathological complete response of NACRT is critical for improving the survival of patients with cStageII-III ESCC. The Rad51 expression in pretreatment biopsy specimens was therefore suggested to be a useful predictive factor for the response to NACRT.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The treatment outcomes of synchronous and metachronous esophageal squamous cell carcinoma and head and neck squamous cell carcinoma2012
Author(s)
Saeki H, Toh Y, Morita M, Sugiyama M, Morita K, Sakamoto Y, Soejima Y, Minami K, Sakaguchi Y, Higaki Y, Uehara S, Okamura T, Maehara Y
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Journal Title
Esophagus
Volume: 9
Pages: 158-64
NAID
Related Report
Peer Reviewed
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