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Prediction of response to neoadjuvant chemotherapy in esophageal cancer patients

Research Project

Project/Area Number 22591461
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of the Ryukyus

Principal Investigator

SHIMOJI Hideaki  琉球大学, 大学院・医学研究科, 助教 (30305205)

Co-Investigator(Kenkyū-buntansha) NISHIMAKI Tadashi  琉球大学, 大学院・医学研究科, 教授 (70242427)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords食道外科学 / 食道癌 / 術前化学療法 / 治療効果予測 / 末梢血中循環癌細胞 / 血中メッセンジャーRNA定量
Research Abstract

The aim of this study was to evaluate the prediction of response to neoadjuvant chemotherapy in esophageal cancer patients. Eight patients were enrolled in this study. In these patients, Circulating Tumor Cells were not detected by Cell Search Method. And CEA m-RNA levels were not detected by RT -PCR. SCC m-RNA levels were detected in all patients, but we could not defined the relationship between the expression of SCC m-RNA and effectiveness of the neoadjuvant chemotherapy in esophageal cancer patients.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Presentation (7 results)

  • [Presentation] 予後不良因子を有する食道癌に対する集学的治療の効果と問題点2012

    • Author(s)
      下地 英明
    • Organizer
      日本消化器外科学会第67回
    • Place of Presentation
      富山市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高度進行食道癌に対する集学的治療の意義と問題点2012

    • Author(s)
      下地 英明
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Different outcomes of multi-modality treatment for patients with esophageal cancer associated with unfavorable prognostic factors2012

    • Author(s)
      下地 英明
    • Organizer
      ISDE2012
    • Place of Presentation
      Venice
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食道癌高度リンパ節転移例に対する術前5-FU/ADM/Nedaplatin (FAN)療法の有用性2011

    • Author(s)
      下地英明
    • Organizer
      JDDW2011
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 予後不良因子を有する食道癌に対する術前化学・化学放射線療法の意義2011

    • Author(s)
      下地英明
    • Organizer
      日本消化器外科学会第66回
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 進行食道癌に対する術前化学療法の有効性2010

    • Author(s)
      下地英明
    • Organizer
      ISDE2010
    • Place of Presentation
      鹿児島Castle Park Hotel
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道癌に対する至適な術前治療:化学療法と化学放射線療法の選択基準2010

    • Author(s)
      下地英明
    • Organizer
      日本外科学会第110回
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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