| Project/Area Number |
22591467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WAKABAYASHI Gou 岩手医科大学, 医学部, 教授 (50175064)
NISHIDUKA Satoshi 岩手医科大学, 医学部, 講師 (50453311)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 食道癌 / γH2AX / 化学放射線療法 / 感受性予測 / γH２X / 放射線化学療法 |
|---|
| Research Abstract |
Radiotherapy and chemotherapy play the main roles in the treatment of esophageal cancer, but the effects and adverse events markedly vary among patients. In this study, the time -course of nuclear DNA double-strand breaks (DSBs) in tumor cells was quantitatively analyzed during chemoradiotherapy using a histone protein, γH2AX, as an index in patients with esophageal cancer responding to radiotherapy and chemotherapy to investigate its association with the clinical effect. Esophageal cancer specimens were collected from 10 patients treated with preoperative chemoradiotherapy between 2010 and 2012. Staining and quantitative analysis of γH2AX have now been completed, and the association of the analytical results with the judgments of the clinical and histological effects is being investigated. The analysis will be completed this year.
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