Efficient induction and maintenance in vivo of tumor antigen specificCD4+ T cells in cancer immunotherapy
| Project/Area Number |
22591487
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tetsu 神戸大学, 医学部附属病院, 助教 (10403247)
KAMIGAKI Takashi 神戸大学, 医学研究科, 客員教授 (20372641)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 小腸大腸肛門外科学 / 腫瘍免疫 / T細胞 / 大腸癌 / CD4+T細胞 |
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| Research Abstract |
The aim of this study is the establishment of antigen specificCD4+T cell immunotherapy for clinical application. It has been ever pointed out that CD8+ T cells and natural killer cells are occupied tumor infiltrative effecter cells. In particular, CD8+T cells play a central role in antigen-specificity, cytotoxicity, and memory formation of cancer immunotherapy. They have identified tumor-specific antigen in various cancers. Therefore, they tried to induce tumor antigen specific cytotoxic CD8 + T cells by using of tumor peptide vaccines. However, they can't get antigen specific CD8+T cells at present sufficiently for easy induction of cell. Meanwhile, in animal models, it has become already evident that the generation of CD8 + memory T cells needs the interaction with CD4+ T cells, such as CD40-CD40L. The induction in vivoof antigen specific CD4+T cells and maintenance at high concentration in the body would be able to generate and keep tumor antigen specific CD8 + T cells. It is expected this immunological response would get a powerful anti-tumor effect.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Extended survival observed in adoptive activated T lymphocyte immunotherapy for advanced lung cancer: results of a multicenter historical cohort study.2012
Author(s)
Iwai K,Soejima K, Kudoh S, Umezato Y, Kaneko T, Yoshimori K, Tokuda H, Yamaguchi T, Mizoo A, Setoguchi Y, Kamigaki T, Fujimoto K, Goto S
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Journal Title
Cancer Immunol Immunother.
Volume: 61巻10号
Pages: 1781-1790
Related Report
Peer Reviewed
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