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Molecular delivery therapy for metastatic liver tumor derived from pancreatic cancer using the nanobubble

Research Project

Project/Area Number 22591513
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

AKADA Masanori  東北大学, 大学院・医学系研究科, 非常勤講師 (20375075)

Co-Investigator(Kenkyū-buntansha) EGAWA Shinichi  東北大学, 大学院・医学系研究科, 教授 (00270679)
KODAMA Tetsuya  東北大学, 大学院・医工学研究科, 教授 (40271986)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords(高周波)超音波検査 / ナノバブル / 抗癌剤 / 膵癌 / 膵島移植 / 肝転移 / (高周波)超音波検査 / 異種移植 / 超音波検査 / 移植モデル
Research Abstract

In this study, we attempted to develop a novel type of nanobubble anticancer agent for treating metastatic liver tumor derived from pancreatic cancer, and to evaluate the effectiveness. We prepared the mice which were received transplantation of tumor cell line, and performed high frequency ultrasonography to the mice using the agent and evaluated the enhancement of the liver in early stage of the transplantation. The enhancement effect was certified and the effect was similar to a microbubble agent used in clinical (SonazoidR).

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (25 results)

  • [Journal Article] Animal models ofdiabetes mellitus for islet transplantation.2012

    • Author(s)
      Sakata N, Yoshimatsu G, Tsuchiya H, Egawa S, Unno M.
    • Journal Title

      Exp Diabetes Res

      Volume: 256707 Pages: 256707-256707

    • DOI

      10.1155/2012/256707

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Encapsulated islets transplantation: Past, presentand future2012

    • Author(s)
      Sakata N, Sumi S, Yoshimatsu G, Goto M, Egawa S, Unno M.
    • Journal Title

      World J Gastrointest Pathophysiol

      Volume: 3 Issue: 1 Pages: 19-26

    • DOI

      10.4291/wjgp.v3.i1.19

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Encapsulated islets transplantation : Past, present and future2012

    • Author(s)
      Sakata N, Sumi S, Yoshimatsu G, Goto M, Egawa S, Unno M
    • Journal Title

      World J Gastrointest Pathophysiol

      Volume: 3 Pages: 19-26

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of co-transplanting mesenchymal stem cells in islet transplantation2011

    • Author(s)
      Sakata N, Goto M, Yoshimatsu G, Egawa S, Unno M.
    • Journal Title

      World J Gastroenterol

      Volume: 17 Issue: 47 Pages: 5150-5155

    • DOI

      10.3748/wjg.v17.i47.5150

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computed tomography reflected endocrine function of the pancreas2011

    • Author(s)
      Sakata N, Egawa S, Rikiyama T, Yoshimatsu G, Masuda K, Ohtsuka H, Ottomo S, Nakagawa K, Hayashi H, Morikawa T, Onogawa T, Yamamoto K, Yoshida H, Akada M, Motoi F, Naitoh T, Katayose Y, Unno M.
    • Journal Title

      J Gastrointest Surg

      Volume: 15 Issue: 3 Pages: 525-532

    • DOI

      10.1007/s11605-010-1406-5

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring transplanted islets by high-frequency ultrasound2011

    • Author(s)
      Sakata N, Kodama T, Chen R, Yoshimatsu G, Goto M, Egawa S, Unno M.
    • Journal Title

      Islets

      Volume: 3 Pages: 259-266

    • URL

      http://dx.doi.org/10.4161/isl.3.5.17058.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring transplanted islets by high-frequency ultrasound2011

    • Author(s)
      Sakata N, Kodama T, Chen R, Yoshimatsu G, Goto M, Egawa S, Unno M
    • Journal Title

      Islets

      Volume: 3 Issue: 5 Pages: 259-66

    • DOI

      10.4161/isl.3.5.17058

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 移植膵島の超音波画像2013

    • Author(s)
      坂田直昭,後藤昌史,小玉哲也,元井冬彦,水間正道,吉松軍平,青木豪,深瀬耕二,大塚英郎,乙供茂,岡田恭穂,中川圭,林洋毅,森川孝則,吉田寛,内藤剛,三浦康,片寄友,里見進,海野倫明
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2013-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ドナー膵の機能評価を予見するためのCT所見に関する検討2013

    • Author(s)
      坂田直昭,江川新一,力山敏樹,吉松軍平,元井冬彦,三浦康,片寄友,海野倫明
    • Organizer
      第40回日本膵・膵島移植研究会
    • Place of Presentation
      高松
    • Year and Date
      2013-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 当科における慢性膵炎に対する取り組み2013

    • Author(s)
      坂田直昭,元井冬彦,吉田寛,内藤剛,三浦康,廣田衛久,正宗淳,片寄友,江川新一,下瀬川徹,海野倫明
    • Organizer
      第194回日本消化器病学会東北支部例会
    • Place of Presentation
      仙台
    • Year and Date
      2013-02-09
    • Related Report
      2012 Final Research Report
  • [Presentation] ドナー膵の機能評価を予見するためのCT所見に関する検討.2013

    • Author(s)
      坂田直昭,江川新一,力山敏樹,吉松軍平,元井 冬彦,三浦 康,片寄 友,海野倫明
    • Organizer
      第40回日本膵・膵島移植研究会
    • Place of Presentation
      高松
    • Related Report
      2012 Annual Research Report
  • [Presentation] Surgical treatment for chronic pancreatitis, discussion of drainage and total pancreatectomy with islet autotransplantation2012

    • Author(s)
      Sakata N, Yoshimatsu G, Aoki T, Ishida M, Fukase K, Ottomo S, Mizuma M, Okada T, Nakagawa K, Hayashi H, Morikawa T, Yoshida H, Motoi F, Naitoh T, Katayose Y, Miura K, Egawa S, Unno M
    • Organizer
      2012 Joint American Pancreatic Association (APA)/ International Association ofPancreatology (IAP) Annual Meeting
    • Place of Presentation
      Miami、USA
    • Year and Date
      2012-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵動静脈奇形に対する新たな治療戦略2012

    • Author(s)
      坂田直昭,後藤昌史,元井冬彦,林洋毅,中川圭,水間正道,山谷英之,長谷川豊,澤田正二郎,吉松軍平,伊藤経夫,菅野敦,廣田衛久,石垣泰,力山敏樹,江川新一,片桐秀樹,下瀬川徹,里見進,海野倫明
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵動静脈奇形に対する治療戦略としての膵全摘術および自家膵島移植2012

    • Author(s)
      坂田直昭(土屋朗之代演),後藤昌史,元井冬彦,林洋毅,中川圭,水間正道,力山敏樹,江川新一,里見進,海野倫明
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Year and Date
      2012-07-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性膵炎の外科的標準治療法としてのFrey手術と膵全摘および自家膵島移植の正当性2012

    • Author(s)
      坂田直昭,元井冬彦,石田晶玄,深瀬耕二,大塚英郎,乙供茂,水間正道,岡田恭穂,中川圭,林洋毅,森川孝則,小野川徹,吉田寛,力山敏樹,内藤剛,片寄友,江川新一,海野倫明
    • Organizer
      第43回日本膵臓学会大会
    • Place of Presentation
      山形
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 本学で施行した自家膵島移植の3例2012

    • Author(s)
      坂田直昭,後藤昌史,元井冬彦,林洋毅,中川圭,水間正道,吉松軍平,石田晶玄,深瀬耕二,乙供茂,大塚英郎,森川孝則,岡田恭穂,吉田寛,小野川徹,力山敏樹,内藤剛,片寄友,江川新一,里見進,海野倫明
    • Organizer
      第24回日本肝胆膵外科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵島移植医療に有用な各種画像モダリティの使用法の確立に向けて2012

    • Author(s)
      坂田直昭,吉松軍平,EbaHathout,小玉哲也,江川新一,力山敏樹,陳鋭,石田晶玄,土屋郎之,後藤昌史,海野倫明
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-04-12
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 高周波超音波検査による異種膵島の移植後急性期変化2012

    • Author(s)
      坂田直昭,小玉哲也,吉松軍平,石田晶玄,土屋朗之,後藤昌史,海野倫明
    • Organizer
      第39回日本膵・膵島移植研究会
    • Place of Presentation
      旭川
    • Year and Date
      2012-03-10
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Intraoperative ultrasound examination is useful for monitoring transplanted islets.2012

    • Author(s)
      Sakata N, Goto M, Yoshimatsu G, Mizuma M, Motoi F, Satomi S, Unno M
    • Organizer
      XXIV International Cogress of The Transplantation Society
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] 島生着に対する超音波検査の有効性2011

    • Author(s)
      坂田直昭,小玉哲也,陳鋭,吉松軍平,後藤昌史,江川新一,海野倫明、移植膵
    • Organizer
      第47回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 移植膵島生着に対する超音波検査の有効性2011

    • Author(s)
      坂田直昭、小玉哲也、陳鋭, 吉松軍平、後藤昌史、江川新一、海野倫明
    • Organizer
      第47回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 本邦2例目の自家膵島移植を行った急性膵炎合併膵動静脈奇形の1例2011

    • Author(s)
      坂田直昭,後藤昌史,元井冬彦,山口賢,伊藤経夫,林洋毅,山谷英之,岡田恭穂,水間正道,長谷川豊,澤田正二郎,石垣泰,廣田衛久,関口悟,藤盛啓成,江川新一,片桐秀樹,下瀬川徹,里見進,海野倫明
    • Organizer
      第42回日本膵臓学会大会
    • Place of Presentation
      弘前
    • Year and Date
      2011-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵全摘+自家膵島移植を行い,良好な耐糖能を得た急性膵炎合併膵動静脈奇形の1例2011

    • Author(s)
      坂田直昭,後藤昌史,元井冬彦,山口賢,林洋毅,山谷英之,関口悟,江川新一,里見進,海野倫明
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 自家膵島移植後6か月間安定した血糖コントロールが得られた膵動静脈奇形の1例2011

    • Author(s)
      坂田直昭,後藤昌史,元井冬彦,山口賢,伊藤経夫,林洋毅,山谷英之,岡田恭穂,水間正道,長谷川豊,澤田正二郎,石垣泰,廣田衛久,関口悟,藤盛啓成,江川新一,片桐秀樹,下瀬川徹,里見進,海野倫明
    • Organizer
      第191回日本消化器病学会東北支部例会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 画像モダリティによる新しい移植膵島生着の評価法2011

    • Author(s)
      坂田直昭,吉松軍平,元井冬彦,内藤剛,力山敏樹,片寄友,江川新一,海野倫明
    • Organizer
      第23回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Ultrasonography examination can visualize transplanted islets and reveal the function of the islets2011

    • Author(s)
      Sakata N, Kodama T, Chen R, Yoshimatsu G, Goto M, Egawa S, Unno M
    • Organizer
      13th World Congress of IPITA (International Pancreas & Islet Transplant Association)
    • Place of Presentation
      チェコプラハ
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 造影MRIによる移植膵島の生着評価法2011

    • Author(s)
      坂田直昭,Eba Hathout,Andre Obenaus,後藤昌史,江川新一,海野倫明
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 膵線房細胞癌切除例の予後と治療方針2011

    • Author(s)
      赤田昌紀,江川新一,上野達也,佐藤俊,後藤慎一,高橋道長,内藤広郎,元井冬彦,力山敏樹,片寄友,海野倫明
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 超音波検査による移植膵島の機能評価2011

    • Author(s)
      坂田直昭,小玉哲也,陳鋭,吉松軍平,後藤昌史,江川新一,海野倫明
    • Organizer
      第38回日本膵・膵島移植研究会
    • Place of Presentation
      奈良
    • Year and Date
      2011-03-04
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel approach for assessment of transplanted islets using imaging modalities2011

    • Author(s)
      Naoaki Sakata
    • Organizer
      Winter Camp of GCOE (Tohoku University)
    • Place of Presentation
      仙台
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性膵炎をくり返す膵動静脈奇形症例に対し自家膵島移植を施行した自験報告2011

    • Author(s)
      坂田直昭,元井冬彦,林洋毅,江川新一,海野倫明,後藤昌史,里見進,山口賢,岡芳知,廣田衛久,下瀬川徹
    • Organizer
      第45回東北膵臓研究会
    • Place of Presentation
      仙台
    • Year and Date
      2011-02-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Observation for angiogenesis of liver metastases in preclinical models2011

    • Author(s)
      Chen R, Watanabe Y, Li L, Horie S, Mori S, Fukumoto M, Kodama T.
    • Organizer
      The 5th International Symposium on Medical, Bio-and Nano-Electronics.
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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