Molecular delivery therapy for metastatic liver tumor derived from pancreatic cancer using the nanobubble

• Project/Area Number: 22591513
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: AKADA Masanori 東北大学, 大学院・医学系研究科, 非常勤講師 (20375075)
• Co-Investigator(Kenkyū-buntansha): EGAWA Shinichi 東北大学, 大学院・医学系研究科, 教授 (00270679) ; KODAMA Tetsuya 東北大学, 大学院・医工学研究科, 教授 (40271986)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: (高周波)超音波検査 / ナノバブル / 抗癌剤 / 膵癌 / 膵島移植 / 肝転移 / （高周波）超音波検査 / 異種移植 / 超音波検査 / 移植モデル

Research Abstract

In this study, we attempted to develop a novel type of nanobubble anticancer agent for treating metastatic liver tumor derived from pancreatic cancer, and to evaluate the effectiveness. We prepared the mice which were received transplantation of tumor cell line, and performed high frequency ultrasonography to the mice using the agent and evaluated the enhancement of the liver in early stage of the transplantation. The enhancement effect was certified and the effect was similar to a microbubble agent used in clinical (SonazoidR).

Research Products

• [Journal Article] Animal models ofdiabetes mellitus for islet transplantation. (2012)
  • Author(s): Sakata N, Yoshimatsu G, Tsuchiya H, Egawa S, Unno M.
  • Journal Title: Exp Diabetes Res Volume: 256707 Pages: 256707-256707
  • DOI: 10.1155/2012/256707
  • Peer Reviewed
• [Journal Article] Encapsulated islets transplantation: Past, presentand future (2012)
  • Author(s): Sakata N, Sumi S, Yoshimatsu G, Goto M, Egawa S, Unno M.
  • Journal Title: World J Gastrointest Pathophysiol Volume: 3 Issue: 1 Pages: 19-26
  • DOI: 10.4291/wjgp.v3.i1.19
  • Peer Reviewed
• [Journal Article] Encapsulated islets transplantation : Past, present and future (2012)
  • Author(s): Sakata N, Sumi S, Yoshimatsu G, Goto M, Egawa S, Unno M
  • Journal Title: World J Gastrointest Pathophysiol Volume: 3 Pages: 19-26
  • Peer Reviewed
• [Journal Article] Utility of co-transplanting mesenchymal stem cells in islet transplantation (2011)
  • Author(s): Sakata N, Goto M, Yoshimatsu G, Egawa S, Unno M.
  • Journal Title: World J Gastroenterol Volume: 17 Issue: 47 Pages: 5150-5155
  • DOI: 10.3748/wjg.v17.i47.5150
  • Peer Reviewed
• [Journal Article] Computed tomography reflected endocrine function of the pancreas (2011)
  • Author(s): Sakata N, Egawa S, Rikiyama T, Yoshimatsu G, Masuda K, Ohtsuka H, Ottomo S, Nakagawa K, Hayashi H, Morikawa T, Onogawa T, Yamamoto K, Yoshida H, Akada M, Motoi F, Naitoh T, Katayose Y, Unno M.
  • Journal Title: J Gastrointest Surg Volume: 15 Issue: 3 Pages: 525-532
  • DOI: 10.1007/s11605-010-1406-5
  • Peer Reviewed
• [Journal Article] Monitoring transplanted islets by high-frequency ultrasound (2011)
  • Author(s): Sakata N, Kodama T, Chen R, Yoshimatsu G, Goto M, Egawa S, Unno M.
  • Journal Title: Islets Volume: 3 Pages: 259-266
  • URL: http://dx.doi.org/10.4161/isl.3.5.17058.
  • Peer Reviewed
• [Journal Article] Monitoring transplanted islets by high-frequency ultrasound (2011)
  • Author(s): Sakata N, Kodama T, Chen R, Yoshimatsu G, Goto M, Egawa S, Unno M
  • Journal Title: Islets Volume: 3 Issue: 5 Pages: 259-66
  • DOI: 10.4161/isl.3.5.17058
  • Peer Reviewed
• [Presentation] 移植膵島の超音波画像 (2013)
  • Author(s): 坂田直昭,後藤昌史,小玉哲也,元井冬彦,水間正道,吉松軍平,青木豪,深瀬耕二,大塚英郎,乙供茂,岡田恭穂,中川圭,林洋毅,森川孝則,吉田寛,内藤剛,三浦康,片寄友,里見進,海野倫明
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2013-04-13
• [Presentation] ドナー膵の機能評価を予見するためのCT所見に関する検討 (2013)
  • Author(s): 坂田直昭,江川新一,力山敏樹,吉松軍平,元井冬彦,三浦康,片寄友,海野倫明
  • Organizer: 第40回日本膵・膵島移植研究会
  • Place of Presentation: 高松
  • Year and Date: 2013-03-02
• [Presentation] 当科における慢性膵炎に対する取り組み (2013)
  • Author(s): 坂田直昭,元井冬彦,吉田寛,内藤剛,三浦康,廣田衛久,正宗淳,片寄友,江川新一,下瀬川徹,海野倫明
  • Organizer: 第194回日本消化器病学会東北支部例会
  • Place of Presentation: 仙台
  • Year and Date: 2013-02-09
• [Presentation] ドナー膵の機能評価を予見するためのCT所見に関する検討. (2013)
  • Author(s): 坂田直昭，江川新一，力山敏樹，吉松軍平，元井 冬彦，三浦 康，片寄 友,海野倫明
  • Organizer: 第40回日本膵・膵島移植研究会
  • Place of Presentation: 高松
• [Presentation] Surgical treatment for chronic pancreatitis, discussion of drainage and total pancreatectomy with islet autotransplantation (2012)
  • Author(s): Sakata N, Yoshimatsu G, Aoki T, Ishida M, Fukase K, Ottomo S, Mizuma M, Okada T, Nakagawa K, Hayashi H, Morikawa T, Yoshida H, Motoi F, Naitoh T, Katayose Y, Miura K, Egawa S, Unno M
  • Organizer: 2012 Joint American Pancreatic Association (APA)/ International Association ofPancreatology (IAP) Annual Meeting
  • Place of Presentation: Miami、USA
  • Year and Date: 2012-11-01
• [Presentation] 膵動静脈奇形に対する新たな治療戦略 (2012)
  • Author(s): 坂田直昭,後藤昌史,元井冬彦,林洋毅,中川圭,水間正道,山谷英之,長谷川豊,澤田正二郎,吉松軍平,伊藤経夫,菅野敦,廣田衛久,石垣泰,力山敏樹,江川新一,片桐秀樹,下瀬川徹,里見進,海野倫明
  • Organizer: JDDW2012
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-10
• [Presentation] 膵動静脈奇形に対する治療戦略としての膵全摘術および自家膵島移植 (2012)
  • Author(s): 坂田直昭(土屋朗之代演),後藤昌史,元井冬彦,林洋毅,中川圭,水間正道,力山敏樹,江川新一,里見進,海野倫明
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山
  • Year and Date: 2012-07-20
• [Presentation] 慢性膵炎の外科的標準治療法としてのFrey手術と膵全摘および自家膵島移植の正当性 (2012)
  • Author(s): 坂田直昭,元井冬彦,石田晶玄,深瀬耕二,大塚英郎,乙供茂,水間正道,岡田恭穂,中川圭,林洋毅,森川孝則,小野川徹,吉田寛,力山敏樹,内藤剛,片寄友,江川新一,海野倫明
  • Organizer: 第43回日本膵臓学会大会
  • Place of Presentation: 山形
  • Year and Date: 2012-06-28
• [Presentation] 本学で施行した自家膵島移植の3例 (2012)
  • Author(s): 坂田直昭,後藤昌史,元井冬彦,林洋毅,中川圭,水間正道,吉松軍平,石田晶玄,深瀬耕二,乙供茂,大塚英郎,森川孝則,岡田恭穂,吉田寛,小野川徹,力山敏樹,内藤剛,片寄友,江川新一,里見進,海野倫明
  • Organizer: 第24回日本肝胆膵外科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2012-05-30
• [Presentation] 膵島移植医療に有用な各種画像モダリティの使用法の確立に向けて (2012)
  • Author(s): 坂田直昭,吉松軍平,EbaHathout,小玉哲也,江川新一,力山敏樹,陳鋭,石田晶玄,土屋郎之,後藤昌史,海野倫明
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2012-04-12
• [Presentation] 高周波超音波検査による異種膵島の移植後急性期変化 (2012)
  • Author(s): 坂田直昭,小玉哲也,吉松軍平,石田晶玄,土屋朗之,後藤昌史,海野倫明
  • Organizer: 第39回日本膵・膵島移植研究会
  • Place of Presentation: 旭川
  • Year and Date: 2012-03-10
• [Presentation] Intraoperative ultrasound examination is useful for monitoring transplanted islets. (2012)
  • Author(s): Sakata N, Goto M, Yoshimatsu G, Mizuma M, Motoi F, Satomi S, Unno M
  • Organizer: XXIV International Cogress of The Transplantation Society
  • Place of Presentation: Berlin, Germany
• [Presentation] 島生着に対する超音波検査の有効性 (2011)
  • Author(s): 坂田直昭,小玉哲也,陳鋭,吉松軍平,後藤昌史,江川新一,海野倫明、移植膵
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-05
• [Presentation] 移植膵島生着に対する超音波検査の有効性 (2011)
  • Author(s): 坂田直昭、小玉哲也、陳鋭, 吉松軍平、後藤昌史、江川新一、海野倫明
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-05
• [Presentation] 本邦2例目の自家膵島移植を行った急性膵炎合併膵動静脈奇形の1例 (2011)
  • Author(s): 坂田直昭,後藤昌史,元井冬彦,山口賢,伊藤経夫,林洋毅,山谷英之,岡田恭穂,水間正道,長谷川豊,澤田正二郎,石垣泰,廣田衛久,関口悟,藤盛啓成,江川新一,片桐秀樹,下瀬川徹,里見進,海野倫明
  • Organizer: 第42回日本膵臓学会大会
  • Place of Presentation: 弘前
  • Year and Date: 2011-07-29
• [Presentation] 膵全摘+自家膵島移植を行い,良好な耐糖能を得た急性膵炎合併膵動静脈奇形の1例 (2011)
  • Author(s): 坂田直昭,後藤昌史,元井冬彦,山口賢,林洋毅,山谷英之,関口悟,江川新一,里見進,海野倫明
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-15
• [Presentation] 自家膵島移植後6か月間安定した血糖コントロールが得られた膵動静脈奇形の1例 (2011)
  • Author(s): 坂田直昭,後藤昌史,元井冬彦,山口賢,伊藤経夫,林洋毅,山谷英之,岡田恭穂,水間正道,長谷川豊,澤田正二郎,石垣泰,廣田衛久,関口悟,藤盛啓成,江川新一,片桐秀樹,下瀬川徹,里見進,海野倫明
  • Organizer: 第191回日本消化器病学会東北支部例会
  • Place of Presentation: 盛岡
  • Year and Date: 2011-07-08
• [Presentation] 画像モダリティによる新しい移植膵島生着の評価法 (2011)
  • Author(s): 坂田直昭,吉松軍平,元井冬彦,内藤剛,力山敏樹,片寄友,江川新一,海野倫明
  • Organizer: 第23回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-09
• [Presentation] Ultrasonography examination can visualize transplanted islets and reveal the function of the islets (2011)
  • Author(s): Sakata N, Kodama T, Chen R, Yoshimatsu G, Goto M, Egawa S, Unno M
  • Organizer: 13th World Congress of IPITA (International Pancreas & Islet Transplant Association)
  • Place of Presentation: チェコプラハ
  • Year and Date: 2011-06-03
• [Presentation] 造影MRIによる移植膵島の生着評価法 (2011)
  • Author(s): 坂田直昭,Eba Hathout,Andre Obenaus,後藤昌史,江川新一,海野倫明
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-26
• [Presentation] 膵線房細胞癌切除例の予後と治療方針 (2011)
  • Author(s): 赤田昌紀,江川新一,上野達也,佐藤俊,後藤慎一,高橋道長,内藤広郎,元井冬彦,力山敏樹,片寄友,海野倫明
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-26
• [Presentation] 超音波検査による移植膵島の機能評価 (2011)
  • Author(s): 坂田直昭,小玉哲也,陳鋭,吉松軍平,後藤昌史,江川新一,海野倫明
  • Organizer: 第38回日本膵・膵島移植研究会
  • Place of Presentation: 奈良
  • Year and Date: 2011-03-04
• [Presentation] A novel approach for assessment of transplanted islets using imaging modalities (2011)
  • Author(s): Naoaki Sakata
  • Organizer: Winter Camp of GCOE (Tohoku University)
  • Place of Presentation: 仙台
  • Year and Date: 2011-02-05
• [Presentation] 急性膵炎をくり返す膵動静脈奇形症例に対し自家膵島移植を施行した自験報告 (2011)
  • Author(s): 坂田直昭,元井冬彦,林洋毅,江川新一,海野倫明,後藤昌史,里見進,山口賢,岡芳知,廣田衛久,下瀬川徹
  • Organizer: 第45回東北膵臓研究会
  • Place of Presentation: 仙台
  • Year and Date: 2011-02-04
• [Presentation] Observation for angiogenesis of liver metastases in preclinical models (2011)
  • Author(s): Chen R, Watanabe Y, Li L, Horie S, Mori S, Fukumoto M, Kodama T.
  • Organizer: The 5th International Symposium on Medical, Bio-and Nano-Electronics.
  • Place of Presentation: 仙台