| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
Angiotensin II (Ang II) receptor AT-1 and receptor of trypsin (PAR-2) were observed in fibroblasts and cancer cells in intrahepatic cholangiocarcinoma (ICC) tissue. In addition, AT-1 receptor expression was detected in ICC and hepatic stellate cell lines. Moreover, Ang II caused proliferative potential of ICC and hepatic stellate cells and Ang II increased activation of hepatic stellate cells. These reactionswere inhibited by the addition of Ang II receptor blocker (ARB). It was suggested thatlocal Ang II production system affect to interstitial fibrosis and proliferation of tumor cells in ICC tissue, and that there are anti-tumor and anti-fibrotic effects in ARB.
|
