2012 Fiscal Year Final Research Report
Development of new refractory cancer treatment by remodelinginduction of cancer stroma
| Project/Area Number |
22591515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
OHTA Tetsuo 金沢大学, 医学系, 教授 (40194170)
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Hirohisa 金沢大学, 医学系, 講師 (80272970)
TAJIMA Hidehiro 金沢大学, 医学系, 助教 (00436825)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癌間質 / 線維化 / アンギオテンシン / トリプシン / 胆管癌 / ARB / PAR2 |
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| Research Abstract |
Angiotensin II (Ang II) receptor AT-1 and receptor of trypsin (PAR-2) were observed in fibroblasts and cancer cells in intrahepatic cholangiocarcinoma (ICC) tissue. In addition, AT-1 receptor expression was detected in ICC and hepatic stellate cell lines. Moreover, Ang II caused proliferative potential of ICC and hepatic stellate cells and Ang II increased activation of hepatic stellate cells. These reactionswere inhibited by the addition of Ang II receptor blocker (ARB). It was suggested thatlocal Ang II production system affect to interstitial fibrosis and proliferation of tumor cells in ICC tissue, and that there are anti-tumor and anti-fibrotic effects in ARB.
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