| Project/Area Number |
22591524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyushu University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
MIYASAKA Yoshihiro 九州大学, 医学研究院, 共同研究員 (40507795)
MIZUMOTO Kazuhiro 九州大学, 大学病院, 准教授 (90253418)
TSUTSUMI Kohsuke 九州大学, 医学研究院, 共同研究員 (00467937)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 膵癌 / オートファジー / 薬剤耐性 / 遺伝子治療 / ASC |
|---|
| Research Abstract |
Autophagy has been recently identified as a new mechanism to maintain protein degradation, and lots of efforts have been made to clarify this complicated mechanism. The mains of this study were to investigate the roles of autophagy in biological behavior and chemoresistance in pancreatic cancer, and to show the possibility of autophagy for the application of the treatment of pancreatic cancer. Salinomycin decrease cell viability in pancreatic cancer cell lines in dose- and time-dependent manner, and also induced autophagy. Salinomycin decreased expression levels of Akt and mTOR, regulators of tumor progression, and induced apoptosis. Taken together, autophagy would increase chemo-sensitivity and might be applicable for the treatment of pancreatic cancer.
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