Anti-cancer effects and mechanism induced by nanoperticles laoded amino acid for biliary and pancreatic cancer cells

• Project/Area Number: 22591528
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Yokohama City University
• Principal Investigator: MATSUYAMA Ryusei 横浜市立大学, 医学部, 助教 (30464548)
• Co-Investigator(Kenkyū-buntansha): SHIROTAKE Shoichi 横浜市立大学, 医学研究科, 准教授 (20143274) ; ENDO Itaru 横浜市立大学, 医学研究科, 教授 (60211091)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ナノ粒子 / 膵癌細胞 / 増殖抑制効果

Research Abstract

In our study, results usingGly(Shirotake et al. Chem. Perm. Bull. 56(1):137-138, 2008) has been reportedanti-tumor activityis highamong thenanoperticles loaded amino acid likelyhighergrowth inhibitoryeffect onpancreatic cancercell lineMIA-Paca2was suggested.The detailed elucidation of the mechanism of the action mechanism will consider a subject from now on.The possibility as an effective cure for which the anticancer drug treatment to bile duct and pancreatic cancer will be substituted in the future is expected.