Molecular pathogenesis of aortic dissection

• Project/Area Number: 22591543
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: SUZUKI Ryo 山口大学, 医学部附属病院, 助教 (10570319)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Koichi 山口大学, 大学院・医学系研究科, 准教授(特 命) (00322248) ; SATO Masafumi 山口大学, 医学部附属病院, 医員 (20346547)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 大動脈解離

Research Abstract

Acute aortic dissection is a common life-threatening disorder affecting the aorta. The mechanisms underlying the development of aortic dissection remain largely unknown. In this study, we examined the significance of angiotensin II signaling in the development of aortic dissection.

Research Products

• [Journal Article] Important Role of the Angiotensin II Pathway in Producing Matrix Metalloproteinase-9 in Human Thoracic Aortic Aneurysms (2013)
  • Author(s): Nagasawa A, Yoshimura K, Suzuki R, Mikamo A, Yamashita O, Ikeda Y, Tsuchida M, Hamano K
  • Journal Title: Journal of Surgical Research Volume: (in press) Issue: 1 Pages: 472-7
  • DOI: 10.1016/j.jss.2012.12.012
  • Peer Reviewed
• [Journal Article] Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm (2012)
  • Author(s): Yoshimura K, Aoki H
  • Journal Title: International Journal of Vascular Medicine Volume: 2012: 648167 Pages: 648167-648167
  • DOI: 10.1155/2012/648167
  • Peer Reviewed
• [Journal Article] 大動脈解離発生における JNK アイソフォームの役割 (2012)
  • Author(s): 長澤綾子,吉村耕一,濱野公一,土田正則
  • Journal Title: 新潟県医師会報 Volume: 752 Pages: 8-10
• [Journal Article] Validation of the JapanSCORE versus the logistic EuroSCORE for predicting operative mortality of cardiovascular surgery in Yamaguchi University Hospital (2011)
  • Author(s): Kurazumi H, Mikamo A, Fukamitsu G, Kudou T, Sato M, Suzuki R, Ikenaga S, Shirasawa B, Hamano K
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 59(9) Issue: 9 Pages: 599-604
  • DOI: 10.1007/s11748-011-0784-2
  • NAID: 10030549326
  • Peer Reviewed
• [Journal Article] The effects of mechanical stress on the growth, differentiation, and paracrine factor production of cardiac stem cells (2011)
  • Author(s): Kurazumi H, Kubo M, Ohshima M, Yamamoto Y, Takemoto Y, Suzuki R, Ikenaga S, Mikamo A, Udo K, Hamano K, Li TS
  • Journal Title: PLoS One Volume: 6(12) Issue: 12 Pages: e28890-e28890
  • DOI: 10.1371/journal.pone.0028890
  • Peer Reviewed
• [Journal Article] Delayed sternal closure after vacuum-assisted closure therapy for tracheo-innominate artery fistula repair (2011)
  • Author(s): Suzuki R, Mikamo A, Kurazumi H, Hamano K
  • Journal Title: Interact Cardiovasc Thorac Surg Volume: 13(2) Issue: 2 Pages: 229-31
  • DOI: 10.1510/icvts.2011.269985
  • Peer Reviewed
• [Journal Article] Secondary omental and pectoralis major double flap reconstruction following aggressive sternectomy for deep sternal wound infections after cardiac surgery (2011)
  • Author(s): Kobayashi T, Mikamo A, Kurazumi H, Suzuki R, Shirasawa B, Hamano K
  • Journal Title: J Cardiothorac Surg Volume: 18;6 Issue: 1 Pages: 56-56
  • DOI: 10.1186/1749-8090-6-56
  • Peer Reviewed
• [Journal Article] Mitral-valve replacement for a severely calcified mitral annulus: a simple and novel technique (2011)
  • Author(s): Kurazumi H, Mikamo A, Suzuki R, Hamano K
  • Journal Title: Eur J Cardiothorac Surg Volume: 39(3) Issue: 3 Pages: 407-9
  • DOI: 10.1016/j.ejcts.2010.06.017
  • Peer Reviewed
• [Journal Article] Transforming growth factor- β receptor type 1 遺伝子の変異を認めた非 Marfan 症候群の家族性大動脈解離 (2011)
  • Author(s): 鈴木 亮, 美甘章仁, 藏澄宏之, 佐藤正史, 池田宜孝, 白澤文吾, 濱野公一
  • Journal Title: 胸部外科 Volume: 64(2) Pages: 99-104
  • Peer Reviewed
• [Journal Article] Transforming growth factor-β receptor type 1遺伝子の変異を認めた非Marfan症候群の家族性大動脈解離 (2011)
  • Author(s): 鈴木亮, 他
  • Journal Title: 胸部外科 Volume: 64 Pages: 99-104
  • Peer Reviewed
• [Journal Article] Left ventricular free wall rupture detected by multidetector computed tomography after mitral valve replacement (2010)
  • Author(s): Suzuki R, Mikamo A, Kurazumi H, Hamano K
  • Journal Title: J Card Surg Volume: 25(6) Issue: 6 Pages: 699-699
  • DOI: 10.1111/j.1540-8191.2010.01107.x
  • Peer Reviewed
• [Journal Article] Simple geometrical infarct exclusion technique with a single patch for postinfarction ventricular septal perforation (2010)
  • Author(s): Kobayashi T, Mikamo A, Suzuki R, Murakami M, Shirasawa B, Hamano K
  • Journal Title: Ann Thorac Surg Volume: 89(6) Issue: 6 Pages: 2049-52
  • DOI: 10.1016/j.athoracsur.2009.08.013
  • Peer Reviewed
• [Presentation] Molecular Pathogenesis of Abdominal Aortic Aneurysm (2013)
  • Author(s): Yoshimura K
  • Organizer: Seminor in Karolinska institutet
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2013-02-21
• [Presentation] Role of JNK2 in Aortic Aneurysms and Dissections (2013)
  • Author(s): Nagasawa A, Yoshimura K, Yamashita O, Ikeda Y, Aoki H, Hamano K
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜 パシフィコ横浜
• [Presentation] c-Jun N-terminal kinase(JNK)の大動脈解離発症への関与 (2013)
  • Author(s): 長澤綾子,吉村耕一,山下 修, 鈴木 亮, 美甘章仁, 土田正則, 濱野公一
  • Organizer: 第43回日本心臓血管外科学会
  • Place of Presentation: 東京 ホテルグランパシフィック LE DAIBA
• [Presentation] JNK2が大動脈解離発生に関与する (2013)
  • Author(s): 長澤綾子
  • Organizer: 第113回日本外科学会
  • Place of Presentation: 福岡国際会議場（福岡）
• [Presentation] c-Jun N-terminal kinase(JNK)の大動脈解離発症への関与 (2013)
  • Author(s): 長澤綾子
  • Organizer: 第43回日本心臓血管外科学会
  • Place of Presentation: ホテルグランパシフィックLE DAIBA（東京）
• [Presentation] 大動脈瘤・解離における JNK2 の役割 (2012)
  • Author(s): 長澤綾子,吉村耕一,山下 修,濱野公一
  • Organizer: 大動脈瘤・解離における JNK2 の役割.
  • Place of Presentation: 久留米 久留米大学
  • Year and Date: 2012-08-30
• [Presentation] Role of Signaling Pathways in Aortic Aneurysms (2012)
  • Author(s): Yoshimura K
  • Organizer: 3rd International Meeting on Aortic Diseases -New insights into an old problem
  • Place of Presentation: Liege, Belgium
• [Presentation] Angiotensin II pathway is critical for MMP-9 production in human thoracic aortic aneurysms (2012)
  • Author(s): Nagasawa A, Yoshimura K, Yamashita O, Tsuchida M, Hamano K
  • Organizer: 3rd International Meeting on Aortic Diseases -New insights into an old problem
  • Place of Presentation: Liege, Belgium
• [Presentation] Increased levels of periostin in abdominal aortic aneurysms (2012)
  • Author(s): Yamashita O, Yoshimura K, Nagasawa A, Morikage N, Hamano K
  • Organizer: 3rd International Meeting on Aortic Diseases -New insights into an old problem
  • Place of Presentation: Liege, Belgium
• [Presentation] Adventitial inversion technique を用いた急性 A 型解離手術 (2012)
  • Author(s): 藏澄宏之, 美甘章仁, 中村玉美, 工藤智明, 鈴木 亮, 池永 茂, 白澤文吾, 濱 野 公 一
  • Organizer: 第40回日本血管外科学会
  • Place of Presentation: 長野 長野ビッグハット
• [Presentation] 外科領域における凝固障害症例の治療戦略を探る A 型急性大動脈解離手術時における術中出血量の予測因子術前因子から凝固障害は予測可能か (2012)
  • Author(s): 鈴木 亮, 美甘章仁, 中村玉美, 工藤智明, 藏澄宏之, 池永 茂, 白澤文吾, 濱野公一
  • Organizer: 第112回日本外科学会
  • Place of Presentation: 千葉 幕張メッセ
• [Presentation] B型大動脈解離に対するTEVAR(Thoracic endovascular aortic repair)後の遠隔期予後 (2012)
  • Author(s): 工藤智明, 美甘章仁, 藏澄宏之, 鈴木亮, 池永 茂, 白澤文吾, 森景則保, 濱野 公 一
  • Organizer: 第112回日本外科学会
  • Place of Presentation: 千葉 幕張メッセ
• [Presentation] 大動脈解離における c-Jun N-terminal kinase(JNK)の役割 (2012)
  • Author(s): 長澤綾子,吉村耕一,鈴木 亮, 藏澄宏之, 池永 茂, 美甘章仁, 濱野公一
  • Organizer: 第112回日本外科学会
  • Place of Presentation: 千葉 幕張メッセ
• [Presentation] 当科における早期血栓閉塞型 Stanford A 型急性大動脈解離に対する治療戦略 (2011)
  • Author(s): 鈴木 亮, 美甘章仁, 深光 岳, 工藤智明, 藏澄宏之, 佐藤正史, 白澤文吾, 濱野公一
  • Organizer: 第39回日本血管外科学会
  • Place of Presentation: 沖縄 沖縄コンベンションセンター
• [Presentation] A 型解離上行置換術後の残存解離拡大に対する左開胸による弓部～下行大動脈置換術 (2011)
  • Author(s): 藏澄宏之, 美甘章仁, 深光 岳, 工藤智明, 佐藤正史, 鈴木 亮, 池永 茂, 白澤文吾, 濱野公一
  • Organizer: 第39回日本血管外科学会
  • Place of Presentation: 沖縄 沖縄コンベンションセンター
• [Presentation] 上行置換術後の慢性大動脈解離に対しarch translocation後、二期的にtotal aortic repairを行った2例 (2010)
  • Author(s): 鈴木亮, 他
  • Organizer: 日本血管外科学会
  • Place of Presentation: さいたま
  • Year and Date: 2010-05-21
• [Presentation] 上行置換術後の慢性大動脈解離に対しarch translocation 後、二期的に total aortic repair を行った 2 例 (2010)
  • Author(s): 鈴木 亮, 美甘章仁, 藏澄宏之, 佐藤正史, 池田宜孝, 白澤文吾, 濱野公一
  • Organizer: 第38回日本血管外科学会
  • Place of Presentation: 埼玉 大宮ソニックシティー
• [Book] 第3 節大動脈瘤モデル. 疾患モデルの作製と利用-循環器疾患 (2010)
  • Author(s): 吉村耕一, 青木浩樹
  • Publisher: エル・アイ・シー
• [Book] 大動脈瘤研究の現状と課題. 循環器疾患のサイエンス(小室一成編) (2010)
  • Author(s): 青木浩樹, 吉村耕一
  • Publisher: 南山堂
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~surg-1/