| Project/Area Number |
22591556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GAMOH Shuji 九州保健福祉大学, 薬学部, 講師 (20273930)
KANAI Tasuku 九州保健福祉大学, 薬学部, 助教 (20551295)
MATSUO Yasuko 九州保健福祉大学, 薬学部, 助手 (30551296)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 心バイパス手術 / バイパスグラフト / れん縮 / セロトニン / ヒト伏在静脈 / 血管グラフト / 糖尿病 / スパズム / インスリン / ミオシン軽鎖キナーゼ / ミオシン軽鎖脱リン酸化酵素 / 循環器疾患 / バイパス手術 / ミオシン軽鎖リン酸化酵素 |
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| Research Abstract |
The aim of this study is to determine whether diabetes mellitus (DM) is a high risk factor for coronary artery bypass grafting (CABG). In isolated human endothelium-denuded saphenous vein (SV), the constrictions caused by 5-hydroxytryptamine (5-HT) were significantly greater (hyperreactivity) in the DM patients than in the non-DM (NDM) patients. In the study, we demonstrated that the hyperreactivity to 5-HT in the SV smooth muscle of DM patients resulted from not only the enhanced phosphorylation of myosin light chain phosphatase (MLCP) but also the defective protein levels of MLCP. Furthermore, we demonstrated that the relaxant effect of insulin on 5-HT-induced constriction of SV is mediated in part by the internalization of plasma membrane 5-HT2A receptors and the production of nitric oxide via the PI3-K/Akt pathway. In conclusion,we demonstrated that DM is a high risk factor for CABG.
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