| Project/Area Number |
22591558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINO Ichiro 千葉大学, 大学院・医学研究院, 教授 (40281547)
SAKAIRI Yuichi 千葉大学, 医学部附属病院, 医員 (30551949)
SUZUKI Hidemi 千葉大学, 医学部附属病院, 助教 (60422226)
IWATA Takekazu 千葉大学, 医学部附属病院, 助教 (30586681)
MIZOBUCHI Teruaki 千葉大学, 医学部附属病院, 講師 (50569861)
CHIYO Masako 千葉大学, 医学部附属病院, 医員 (30375688)
和田 啓伸 千葉大学, 医学部附属病院, 医員 (90514604)
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| Co-Investigator(Renkei-kenkyūsha) |
WADA Hironobu University Health Network, Toronto, Canada, Division of Thoracic Surgery, Latner Thoracic Surgery Research Laboratories, Research Fellow (90514604)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 呼吸器外科学 / 移植・再生 / 肺移植 / II型肺胞上皮 / 再生医療 / 虚血潅流傷害 / 死体ドナー肺 / II型肺胞上皮細胞 / 虚血再潅流傷害 / 代償性肺成長 |
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| Research Abstract |
We established isolation of the type II alveolar epithelial cells (AT-II). We confirmed the engraftment of the transplanted AT-II cells to the right lung after left pneumonectomized rats. Human AT-II cells functions were analyzed and the engraftment of transferred human AT-II cells to immunodeficient rats were confirmed. And we established the ischemia-reperfusion injury lung model in rat. To investigate the potential to regenerate lung injury by transferred AT-II cells in the lung injury model, aimed at indications of cadaveric donor lung.
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