Trial of the pulmonary ischemic re-perfusion injury suppression by the suppression of the mitochondrial injury

• Project/Area Number: 22591565
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Osaka University
• Principal Investigator: MINAMI Masato 大阪大学, 医学部附属病院, 准教授 (10240847)
• Co-Investigator(Kenkyū-buntansha): OKUMURA Meinoshin 大阪大学, 医学系研究科, 教授 (40252647) ; SAWABATA Noriyoshi 大阪大学, 医学系研究科, 准教授 (50403184) ; INOUE Masayoshi 大阪大学, 医学系研究科, 講師 (10379232) ; KADOTA Yoshihisa 大阪大学, 医学系研究科, 助教 (50464243) ; 中桐 伴行 大阪大学, 医学(系)研究科(研究院), 助教 (70528710)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 肺移植 / 虚血再灌流障害 / ミトコンドリア障害 / ミトコンドリア / サイクロフィリンＤ / サイクロフィリン / サイクロスポリン / 虚血再環流障害

Research Abstract

The main factor affecting the outcome of the lung transplantation is chronic resection. It is said that one of the causesis the presence of the ischemia re-perfusion injury after transplantation. An intense mitochondrial injury appears at the time of re-perfusion. Mitochondrial injury (PT: permeability transition) is derived through oxidation stress at the time of re-perfusion, and at that time, a large quantity of mitochondrial protein leaks. Mitochondrial protein outflow was suppressed by the hydrogen inhalation, and a pulmonary ischemia re-perfusion was suppressed.

Research Products

• [Journal Article] Null allele alpha-1 antitrypsin deficiency: case report of the total pleural covering technique for disease-associated pneumothorax (2012)
  • Author(s): Kusu T, Nakagiri T, Minami M, Shintani Y, Kadota Y, Inoue M, Sawabata N, Okumura M.
  • Journal Title: Gen Thorac Cardiovasc Surg. Volume: 60 Pages: 452-5
  • NAID: 10031121138
• [Journal Article] 肺移植の現状と課題 (2012)
  • Author(s): 南正人
  • Journal Title: 大阪大学医学部学友会 Volume: 32 Pages: 107-113
• [Journal Article] The effect of donor treatment with hydrogen on lung allograft function in rats. (2011)
  • Author(s): Kawamura T, Huang CS, Peng X, Masutani K, Shigemura N, Billiar TR, Okumura M, Toyoda Y, Nakao A
  • Journal Title: Surgery. Volume: 150 Pages: 240-9
• [Journal Article] びまん性肺疾患と肺移植の適応 (2011)
  • Author(s): 南正人
  • Journal Title: 綜合臨牀 Volume: 60 Pages: 2419-2424
• [Journal Article] 肺移植後急性期の血管合併症について (2010)
  • Author(s): 南正人、井上匡美、中桐伴行, 他
  • Journal Title: 移植 Volume: 45 Pages: 345-352
  • NAID: 10027648716
  • Peer Reviewed
• [Journal Article] Local IL-17 Production and a Decrease in Peripheral Blood Regulatory T cells in an Animal Model of Bronchiolitis Obliterans (2010)
  • Author(s): Nakagiri T, Inoue M, Morii E, Minami M, Sawabata N, Utsumi T, Kadota Y, Ideguchi K, Tokunaga T, Okumura M
  • Journal Title: Transplantation Volume: 89 Pages: 1312-1319
  • Peer Reviewed
• [Presentation] Inhalation of hydrogen reduced transplant-induced ischemia/reperfusion lung injury in rat through heme oxygenase-1 induction (2012)
  • Author(s): Kawamura T, Okumura M
  • Organizer: The 9thlung transplantation conference Fukuoka
  • Year and Date: 2012-10-18
• [Presentation] 肺移植 (2011)
  • Author(s): 南 正人
  • Organizer: 移植医療研究会
  • Place of Presentation: 大阪
  • Year and Date: 2011-05-22
• [Presentation] 肺移植 (2011)
  • Author(s): 南正人
  • Organizer: 移植医療勉強会(21)
  • Place of Presentation: 大阪
  • Year and Date: 2011-05-22
• [Presentation] 肺移植 (2010)
  • Author(s): 南正人
  • Organizer: 第4回全国PH大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-31
• [Presentation] 生体肺移植ドナーの保護-肺機能の温存をはかるための肺動脈形成の積極的適応 (2010)
  • Author(s): 南正人
  • Organizer: 第46回日本移植学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-22
• [Presentation] 我が国の肺移植の現状と実践 (2010)
  • Author(s): 南正人
  • Organizer: 第1回長崎呼吸器疾患と移植再生フォーラム
  • Place of Presentation: 長崎(招待講演)
  • Year and Date: 2010-04-15
• [Presentation] 胸膜癒着が想定される症例への術式選択・術中管理について (2010)
  • Author(s): 南正人
  • Organizer: 第27回日本呼吸器外科学会総会
  • Place of Presentation: 仙台
• [Presentation] リンパ節転移様式を基にした病期IIIA N2非小細胞肺癌(NSCLC)に対する外科治療の検討-今後のTNM分類を見据えて- (2010)
  • Author(s): 中桐伴行
  • Organizer: 第110回日本外科学会定期学術総会
  • Place of Presentation: 名古屋
• [Presentation] 我が国における肺移植の現状 ‐肺および心肺移植研究会 Registry Report 2013-
  • Author(s): 南正人
  • Organizer: 第29回日本肺および心肺移植研究会
  • Place of Presentation: 千葉