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Trial of the pulmonary ischemic re-perfusion injury suppression by the suppression of the mitochondrial injury

Research Project

Project/Area Number 22591565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

MINAMI Masato  大阪大学, 医学部附属病院, 准教授 (10240847)

Co-Investigator(Kenkyū-buntansha) OKUMURA Meinoshin  大阪大学, 医学系研究科, 教授 (40252647)
SAWABATA Noriyoshi  大阪大学, 医学系研究科, 准教授 (50403184)
INOUE Masayoshi  大阪大学, 医学系研究科, 講師 (10379232)
KADOTA Yoshihisa  大阪大学, 医学系研究科, 助教 (50464243)
中桐 伴行  大阪大学, 医学(系)研究科(研究院), 助教 (70528710)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords肺移植 / 虚血再灌流障害 / ミトコンドリア障害 / ミトコンドリア / サイクロフィリンD / サイクロフィリン / サイクロスポリン / 虚血再環流障害
Research Abstract

The main factor affecting the outcome of the lung transplantation is chronic resection. It is said that one of the causesis the presence of the ischemia re-perfusion injury after transplantation. An intense mitochondrial injury appears at the time of re-perfusion. Mitochondrial injury (PT: permeability transition) is derived through oxidation stress at the time of re-perfusion, and at that time, a large quantity of mitochondrial protein leaks. Mitochondrial protein outflow was suppressed by the hydrogen inhalation, and a pulmonary ischemia re-perfusion was suppressed.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] Null allele alpha-1 antitrypsin deficiency: case report of the total pleural covering technique for disease-associated pneumothorax2012

    • Author(s)
      Kusu T, Nakagiri T, Minami M, Shintani Y, Kadota Y, Inoue M, Sawabata N, Okumura M.
    • Journal Title

      Gen Thorac Cardiovasc Surg.

      Volume: 60 Pages: 452-5

    • NAID

      10031121138

    • Related Report
      2012 Final Research Report
  • [Journal Article] 肺移植の現状と課題2012

    • Author(s)
      南正人
    • Journal Title

      大阪大学医学部学友会

      Volume: 32 Pages: 107-113

    • Related Report
      2012 Annual Research Report
  • [Journal Article] The effect of donor treatment with hydrogen on lung allograft function in rats.2011

    • Author(s)
      Kawamura T, Huang CS, Peng X, Masutani K, Shigemura N, Billiar TR, Okumura M, Toyoda Y, Nakao A
    • Journal Title

      Surgery.

      Volume: 150 Pages: 240-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] びまん性肺疾患と肺移植の適応2011

    • Author(s)
      南正人
    • Journal Title

      綜合臨牀

      Volume: 60 Pages: 2419-2424

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 肺移植後急性期の血管合併症について2010

    • Author(s)
      南正人、井上匡美、中桐伴行, 他
    • Journal Title

      移植

      Volume: 45 Pages: 345-352

    • NAID

      10027648716

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local IL-17 Production and a Decrease in Peripheral Blood Regulatory T cells in an Animal Model of Bronchiolitis Obliterans2010

    • Author(s)
      Nakagiri T, Inoue M, Morii E, Minami M, Sawabata N, Utsumi T, Kadota Y, Ideguchi K, Tokunaga T, Okumura M
    • Journal Title

      Transplantation

      Volume: 89 Pages: 1312-1319

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Inhalation of hydrogen reduced transplant-induced ischemia/reperfusion lung injury in rat through heme oxygenase-1 induction2012

    • Author(s)
      Kawamura T, Okumura M
    • Organizer
      The 9thlung transplantation conference Fukuoka
    • Year and Date
      2012-10-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺移植2011

    • Author(s)
      南 正人
    • Organizer
      移植医療研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺移植2011

    • Author(s)
      南正人
    • Organizer
      移植医療勉強会(21)
    • Place of Presentation
      大阪
    • Year and Date
      2011-05-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺移植2010

    • Author(s)
      南正人
    • Organizer
      第4回全国PH大会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体肺移植ドナーの保護-肺機能の温存をはかるための肺動脈形成の積極的適応2010

    • Author(s)
      南正人
    • Organizer
      第46回日本移植学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 我が国の肺移植の現状と実践2010

    • Author(s)
      南正人
    • Organizer
      第1回長崎呼吸器疾患と移植再生フォーラム
    • Place of Presentation
      長崎(招待講演)
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胸膜癒着が想定される症例への術式選択・術中管理について2010

    • Author(s)
      南正人
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report
  • [Presentation] リンパ節転移様式を基にした病期IIIA N2非小細胞肺癌(NSCLC)に対する外科治療の検討-今後のTNM分類を見据えて-2010

    • Author(s)
      中桐伴行
    • Organizer
      第110回日本外科学会定期学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] 我が国における肺移植の現状 ‐肺および心肺移植研究会 Registry Report 2013-

    • Author(s)
      南正人
    • Organizer
      第29回日本肺および心肺移植研究会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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