Application of hemoglobin vesicles for lung transplantation

• Project/Area Number: 22591575
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: KOHNO Mitsutomo 慶應義塾大学, 医学部, 講師 (10276272)
• Co-Investigator(Kenkyū-buntansha): HORINOUCHI Hirohisa 慶應義塾大学, 医学部, 准教授 (60173647) ; NOMORI Hiroaki 慶應義塾大学, 医学部, 教授 (90146613) ; IZUMI Yotaro 慶應義塾大学, 医学部, 講師 (90245506)
• Co-Investigator(Renkei-kenkyūsha): SAKAI Hiroshi 早稲田大学, 重点領域研究機構, 教授 (70318830)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 移植・再生医療 / 呼吸器外科

Research Abstract

On a mouse pneumonectomy model, the infusion of hemoglobinvesicles compensated for 40% of blood loss caused by pneumonectomy, without interferingwith the recovery of mice from the operation. On a perfusion circuit with hemoglobinvesicles, donor lungs were

Research Products

• [Journal Article] Mitigation of occult lunginjury by pneumonectomy viaminithoracotomy in mice (2012)
  • Author(s): Kohno M, Watanabe M, Izumi Y,Tasaka S, Kitagawa Y, Maruyama I,Kobayashi K.
  • Journal Title: The Thoracicand cardiovascular surgeon Volume: 60 Pages: 124-130
  • Peer Reviewed
• [Journal Article] Mediansternotomy for double lungtransplantation with cardiopulmonarybypass in seven consecutive patients (2012)
  • Author(s): Kohno M, Steinbruchel DA
  • Journal Title: Surgery today Volume: 42 Pages: 406-409
  • Peer Reviewed
• [Journal Article] An isolated tumorperfusion model in mice (2012)
  • Author(s): Duyverman AM*, Kohno M* (*equalcontribution), Roberge S, Fukumura D,Duda DG, Jain RK
  • Journal Title: Natureprotocols Volume: 7 Pages: 749-755
  • Peer Reviewed
• [Journal Article] A transient parabiosisskin transplantation model in mice. (2012)
  • Author(s): Duyverman AM*, Kohno M* (*equalcontribution), Duda DG, Jain RK,Fukumura D.
  • Journal Title: Nature protocols Volume: 7 Pages: 763770-763770
  • Peer Reviewed
• [Journal Article] 縦隔悪性リンパ腫治療後の続発性間質性肺炎に対する肺移植 (2010)
  • Author(s): 河野光智, 長谷川直樹, 岡本真一郎, 近藤丘, 野守裕明
  • Journal Title: 胸部外科 Volume: 63巻 Pages: 1119-1121
  • NAID: 40017389644
  • Peer Reviewed
• [Journal Article] Isobutylmethylxanthine facilitates compensatory lung growth in adult mice. (2010)
  • Author(s): Takahashi Y, Izumi Y, Kohno M, Kawamura M, Ikeda E, Nomori H.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol. Volume: 300 Pages: 453-461
  • Peer Reviewed
• [Presentation] 術中出血に対するヘモグロビン小胞体投与の効果と安全性 -肺切除+40%交換輸血モデルでの検討- (2011)
  • Author(s): 河野光智、後藤太一郎、大塚崇、安樂真樹、泉陽太郎、渡辺真純、堀之内宏久、小林紘一
  • Organizer: 第64回日本胸部外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-12
• [Presentation] 術中出血に対するヘモグロビン小胞体投与の効果と安全度-肺切除+40%交換輸血モデルでの検討- (2011)
  • Author(s): 河野光智
  • Organizer: 第64回日本胸部外科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-12