Preventive effect of marrow stromal cells on stroke and neurodegenerative disease

• Project/Area Number: 22591589
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Ehime University
• Principal Investigator: MOGI Masaki 愛媛大学, 大学院・医学系研究科, 准教授 (20363236)
• Co-Investigator(Kenkyū-buntansha): HORIUCHI Masashi 愛媛大学, 大学院・医学系研究科, 教授 (40150338)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: アンジオテンシンII / 脳梗塞 / 認知症 / 骨髄細胞 / 糖尿病 / 血液脳関門 / 脳卒中 / 認知機能障害 / レニン・アンジオテンシン系 / 血液細胞 / 神経保護効果 / 脳血流改善効果 / 抗炎症効果 / 血管細胞

Research Abstract

We investigated the effect of renin-angiotensin system (RAS) on stroke and dementia. RAS in marrow-derived cells regulated stroke size using chimeric mice which were replaced bone marrows by other kinds of mice. Moreover, regulation of RAS prevented diabetes-induced dementia via inhibition of blood-brain barrier using diabetic mice, KKAy.

Research Products

• [Journal Article] Peroxisome proliferator-activated receptor-γ activation with angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice (2012)
  • Author(s): Mogi M, Min LJ,Shudou M, Jing F, Tsukuda K, Ohshima K, Iwanami J, Horiuchi M
  • Journal Title: Hypertension Volume: 59巻 Issue: 5 Pages: 1079-1088
  • DOI: 10.1161/hypertensionaha.112.192401
  • Peer Reviewed
• [Journal Article] Direcy stimulation of angiotensin II type 2 receptor enhances spatial memory (2012)
  • Author(s): Jing F, Mogi M, Sakata A, Iwanami J, Horiuchi M, et al
  • Journal Title: J Cereb Blood Flow Metab. Volume: 32 Issue: 2 Pages: 248-255
  • DOI: 10.1038/jcbfm.2011.133
  • Peer Reviewed
• [Journal Article] Roles of interleukin 17 in angiotensin II type 1 receptor-mediated insulin resistance (2012)
  • Author(s): Ohshima K, Mogi M, et al
  • Journal Title: Hypertension Volume: 59 Issue: 2 Pages: 493-493
  • DOI: 10.1161/hypertensionaha.111.183178
  • Peer Reviewed
• [Journal Article] Angiotensin II type 2 receptor-interacting protein prevents vascular senescence (2012)
  • Author(s): Min LJ, Mogi M, Iwanami J, Jing F, Horiuchi M, et al
  • Journal Title: J Am Soc Hypertens Volume: (in press) Issue: 3 Pages: 179-184
  • DOI: 10.1016/j.jash.2012.01.006
  • Peer Reviewed
• [Journal Article] Effect of angiotensin II type 2 receptor deletion in hematopoietic cells on brain ischemia-reperfusioninjury (2011)
  • Author(s): Iwanami J, Mogi M, Tsukuda K, Min LJ, Sakata A, Jing F, Ohshima K, Horiuchi M
  • Journal Title: Hypertension Volume: 58巻 Issue: 3 Pages: 404-409
  • DOI: 10.1161/hypertensionaha.111.177873
  • Peer Reviewed
• [Journal Article] Angiotensin II and aldosterone-induced neuronal damage in neurons through an astrocyte-dependent mechanism (2011)
  • Author(s): Min LJ, Mogi M, Iwanami J, Sakata A, Jing F, Tsukuda K, Ohshima K, Horiuchi M
  • Journal Title: Hypertens Res Volume: 34巻 Issue: 6 Pages: 773-778
  • DOI: 10.1038/hr.2011.38
  • NAID: 10031163251
  • Peer Reviewed
• [Journal Article] Irbesartan attenuates ischemic brain damage by inhibition of MCP-1/CCR2 signaling pathway beyond AT_1receptor blockade (2011)
  • Author(s): Tsukuda K, Mogi M, Iwanami J, Min LJ, Jing F, Oshima K, Horiuchi M
  • Journal Title: Biochem Biophys Res Commun Volume: 409巻 Issue: 2 Pages: 275-279
  • DOI: 10.1016/j.bbrc.2011.04.142
  • Peer Reviewed
• [Journal Article] 「高血圧治療の未来への展開」【新規開発中の降圧薬とAT_2受容体刺激薬】 (2011)
  • Author(s): 茂木正樹、堀内正嗣
  • Journal Title: 日本内科学会雑誌 Volume: 100 Pages: 432-440
• [Presentation] PPAR-gamma activation with AT1 receptor blockade prevents blood-brain barrier disruption and cognitive impairment in type 2 diabetic mellitus mice (2012)
  • Organizer: International Conference of Alzheimer's Disease 2012
  • Place of Presentation: Vancouver
  • Year and Date: 2012-08-18
• [Presentation] Vascular Dysfunction and Brain Aging-Role of renin-angiotensin system in the brain- (2012)
  • Author(s): 茂木正樹
  • Organizer: 第19回 日本血管生物医学会学術集会 シンポジジウム
  • Place of Presentation: 東京
• [Presentation] Telmisartan prevents cognitive decline in type 2 diabetic mice with improvement of blood-brain barrier disruption partly due to PPAR-gamma activation (2012)
  • Organizer: 24rd Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney
• [Presentation] Vascular Dysfunction and Brain Aging-Role of renin-angiotensin system in the brain- (2011)
  • Author(s): 茂木正樹
  • Organizer: 血管生物医学会
  • Place of Presentation: 東京(招待講演)(シンポジウム)
  • Year and Date: 2011-12-10
• [Presentation] アンチエイジングからみた高血圧研究高血圧治療と脳のアンチエイジング (2011)
  • Author(s): 茂木正樹
  • Organizer: 日本高血圧学会
  • Place of Presentation: 栃木県総合文化センター(宇都宮)(シンポジウム)
  • Year and Date: 2011-10-20
• [Presentation] 脳卒中研究の最前線(将来の脳保護療法を目指して) (2011)
  • Author(s): 茂木正樹
  • Organizer: 日本高血圧学会
  • Place of Presentation: 栃木県総合文化センター(宇都宮)(招待講演)(日本脳卒中学会合同シンポジウム)
  • Year and Date: 2011-10-20
• [Presentation] アンジオテンシンII 2型受容体刺激薬コンパウンド21(C21)の全身投与によるマウス認知機能改善効果 (2011)
  • Author(s): 茂木正樹
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2011-08-01
• [Presentation] 血球細胞におけるアンジオテンシンII2型受容体欠損は脳梗塞巣を拡大する (2011)
  • Author(s): 茂木正樹
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2011-08-01
• [Presentation] 膵臓癌に合併したTrousseau症候群と考えられた1例 (2011)
  • Author(s): 茂木正樹
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2011-08-01
• [Presentation] How Does the Renin-Angiotensin System Affect Cerebrovascular Events? (2011)
  • Author(s): 茂木正樹
  • Organizer: 日本動脈硬化学会
  • Place of Presentation: ロイトン札幌(札幌)(招待講演)(シンポジウム)
  • Year and Date: 2011-07-15
• [Presentation] アンチエイジングからみた高血圧研究 "高血圧治療と脳のアンチエイジング"Antihypertensive Treatment against Brain Aging (2011)
  • Author(s): 茂木正樹
  • Organizer: 第34回 日本高血圧学会学術総会 シンポジウム
  • Place of Presentation: 宇都宮
• [Presentation] 脳卒中基礎研究の今(将来の新しい脳保護療法を目指して) (2011)
  • Author(s): 茂木正樹
  • Organizer: 第34回 日本高血圧学会学術総会 日本脳卒中学会合同シンポジウム
  • Place of Presentation: 宇都宮
• [Presentation] 脳血管イベント発症にレニン・アンジオテンシン系は如何に影響しているのか?How does the Renin-angiotensin System Affect Cerebrovascular Events (2011)
  • Author(s): 茂木正樹
  • Organizer: 第43回 日本動脈硬化学会総会 シンポジジウム
  • Place of Presentation: 札幌
• [Presentation] Spironolactone Improves Cognitive Decline Observed in Female Type 2 Diabetic Mice (2010)
  • Author(s): 茂木正樹
  • Organizer: International Society of Hypertension
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-08-27
• [Presentation] 高血圧 Up-to-Date Renin-Angiotensin-Aldosterone系の新展開 アンジオテンシン受容体
  • Author(s): 茂木正樹
  • Organizer: 日本高血圧学会（招待講演：シンポジウム）
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 脳血管性認知症の原因と治療 レニン・アンジオテンシン系に着目した血管性認知障害に対する治療戦略
  • Author(s): 茂木正樹
  • Organizer: 第3回 血管性認知障害研究会（招待講演：シンポジウム）
  • Place of Presentation: 東京
  • Invited
• [Presentation] レニン・アンジオテンシン系による血管細胞老化とアンチエイジング
  • Author(s): 茂木正樹
  • Organizer: 脳心血管抗加齢研究会2012（招待講演：シンポジウム）
  • Place of Presentation: 大阪
  • Invited
• [Book] 脳保護はどこまで可能か RAS抑制薬の今日的意義 脳のRAS update オーバービュー (2011)
• [Book] 血管生物医学事典(担当稿) (2011)
  • Author(s): 茂木正樹
  • Publisher: 朝倉書店
• [Remarks]
  • URL: http://www.m.ehime-u.ac.jp/school/biochem1/index.html
• [Remarks] 愛媛大学大学院医学系研究科 分子心血管生物・薬理学分野の紹介
  • URL: http://www.m.ehime-u.ac.jp/school/biochem1/index.html