Preventive effect of marrow stromal cells on stroke and neurodegenerative disease
| Project/Area Number |
22591589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Ehime University |
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Principal Investigator |
MOGI Masaki 愛媛大学, 大学院・医学系研究科, 准教授 (20363236)
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| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Masashi 愛媛大学, 大学院・医学系研究科, 教授 (40150338)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アンジオテンシンII / 脳梗塞 / 認知症 / 骨髄細胞 / 糖尿病 / 血液脳関門 / 脳卒中 / 認知機能障害 / レニン・アンジオテンシン系 / 血液細胞 / 神経保護効果 / 脳血流改善効果 / 抗炎症効果 / 血管細胞 |
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| Research Abstract |
We investigated the effect of renin-angiotensin system (RAS) on stroke and dementia. RAS in marrow-derived cells regulated stroke size using chimeric mice which were replaced bone marrows by other kinds of mice. Moreover, regulation of RAS prevented diabetes-induced dementia via inhibition of blood-brain barrier using diabetic mice, KKAy.
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Report
(4 results)
Research Products
(29 results)
