Role of astrocytes in cerebral microcirculation -observation with two photon intravital microscope-
Project/Area Number |
22591597
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Jichi Medical University |
Principal Investigator |
ISHIKAWA Mami 自治医科大学, 医学部, 准教授 (60212859)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | アストロサイト / 脳虚血再灌流 / くも膜下出血 / 一酸化炭素 / 硫化水素 / 脳血管 / 脳循環 / 脳梗塞 / 蛍光画像 / 血管透過性 / GFAP |
Research Abstract |
GFP-labeled astrocytes and Qdot-labeled arterioles and capillaries were observed with two photon intravital microscope in GFAP-GFP mice. Penetrating arterioles and precapillary arterioles regulate cerebral microcirculation in mice with an infarct or a sub
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway2012
Author(s)
Morikawa T, Kajimura M, Nakamura T, Hishiki T, Nakanishi T, Yukutake Y, Nagahata Y, Ishikawa M, Hattori K, Takenouchi T, Takahashi T, Ishii I, Matsubara K, Kabe Y, Uchiyama S, Nagata E, Gadalla MM, Snyder SH, Suematsu M
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Journal Title
PNAS
Volume: 109
Pages: 1293-1298
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