| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Research Abstract |
We demonstrated that bilateral resection of the facet joints results in intervertebral disc degeneration and segmental instability without spondylolisthesis in the rat. In this animal model, behavioral analysis utilizing CatWalk revealed pain-related behaviors 7 weeks after operation and increase in neurotransmitter related to pain and proinflammatory cytokines were seen in the affected dorsal root ganglia. In addition, we found that the pain-related behaviors were related to nociceptive and neurogenic pain. Further studies are needed to elucidate if the pain-related behaviors result from degenerative process of the intervertebral disc itself influence or irritation of the cauda equina and/or the nerve root secondary to segmental instability in this animal model.
|
