Sphingosine 1-phosphate/S1P receptor axis as a molecular target for therapeutic intervention after spinal cord injury

• Project/Area Number: 22591641
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Jichi Medical University
• Principal Investigator: KIMURA Atsushi 自治医科大学, 医学部, 講師 (20364507)
• Co-Investigator(Kenkyū-buntansha): OHMORI Tsukasa 自治医科大学, 医学部, 講師 (70382843)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脊髄損傷 / 生理活性脂質 / 血管透過性 / アストロサイト / スフィンゴシン1-リン酸 / 2次損傷

Research Abstract

FTY720 is phosphorylated in vivo to produce the active metabolite FTY720-P, which is a nonselective S1P receptor agonist for four of the five known S1P receptors. We examined the therapeutic effects of FTY720 on locomotor recovery after SCI in mice. Oral

Research Products

• [Journal Article] FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms (2012)
  • Author(s): Norimatsu Y, Ohmori T, Kimura A, Madoiwa S, Mimuro J, Seichi A, Yatomi Y, Hoshino Y, Sakata Y.
  • Journal Title: Am J Pathol Volume: 180(4) Issue: 4 Pages: 1625-35
  • DOI: 10.1016/j.ajpath.2011.12.012
  • Peer Reviewed
• [Presentation] FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms (2012)
  • Author(s): Norimatsu Y, Ohmori T, Kimura A, Madoiwa S, Mimuro J, Seichi A, Yatomi Y, Hoshino Y, Sakata Y
  • Organizer: The Orthopaedic Research Society (ORS)
  • Place of Presentation: San Francisco
  • Year and Date: 2012-02-05
• [Presentation] FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms (2012)
  • Author(s): Norimatsu Y, Ohmori T, Kimura A, Madoiwa S, Mimuro J, Seichi A, Yatomi Y, Hoshino Y, Sakata Y
  • Organizer: Orthopaedic Research Society
  • Place of Presentation: San Francisco, USA
• [Presentation] スフィンゴシン 1-リン酸受容体を標的とした新しい脊髄損傷治療法の開発 (2012)
  • Author(s): 乗松 祐佐, 大森 司, 木村 敦, 星地 亜都司, 坂田 洋一, 星野 雄一
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋
• [Presentation] スフィンゴシン1-リン酸受容体アゴニストFTY720は脊髄損傷後の運動機能を早期に改善する (2010)
  • Author(s): 乗松祐佐
  • Organizer: 日本整形外科学会基礎学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2010-10-14
• [Remarks]
  • URL: http://www.jichi.ac.jp/medicine/about/department/clinical/orthopedics/file/graduate_labo.pdf