| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
D-serine (DS) is known for gliotransmitter releasing from astrocyte in the spinal cord. DS activates not only NMDA receptors but also glycine receptors of spinal dorsal horn neurons. However, in the neuropathic pain model the excitatory action by DS was more sensitive than physiological condition, whereas its inhibitory action was less than naive one. These findings show that DS may play an important role on the development of neuropathic pain. Moreover, it has been suggested that the degree of radiculopathy at the various levels of nerve injury depends on activation of spinal microglia.
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