Molecular mechanisms of spinal glia cell activation in chronic pain.
| Project/Area Number |
22591647
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kansai University of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TANIGUCHI Wataru 関西医療大学, 保健医療学部, 准教授 (20453194)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | グリア細胞 / ミクログリア / アストロサイト / D-セリン / L-セリン / 神経障害性疼痛 / 神経根性疼痛 / パッチクランプ法 / パッチクランプ / セリン / 蛍光免疫染色 / NMDA / 疼痛学 / 脳・神経 / 神経科学 / 生理学 / グリア / シグナル伝達 / 脊髄 / 神経伝達物質 |
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| Research Abstract |
D-serine (DS) is known for gliotransmitter releasing from astrocyte in the spinal cord. DS activates not only NMDA receptors but also glycine receptors of spinal dorsal horn neurons. However, in the neuropathic pain model the excitatory action by DS was more sensitive than physiological condition, whereas its inhibitory action was less than naive one. These findings show that DS may play an important role on the development of neuropathic pain. Moreover, it has been suggested that the degree of radiculopathy at the various levels of nerve injury depends on activation of spinal microglia.
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Report
(4 results)
Research Products
(105 results)
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[Journal Article] analysis of dopaminergic antinociceptive actions on substantia gelatinosa neurons in the spinal cord2011
Author(s)
Unezaki S, Sasaki A, Mabuchi T, Matsumura S, Katano T, Nakazawa T, Nishio N, Andoh T, Yamamoto T, Nakatsuka T, Kuraishi Y, Ito S
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Journal Title
Pain
Volume: 152
Pages: 95-105
Related Report
Peer Reviewed
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