The efficacy of blood biomarkers in acute or sub-acute spinal cord injury
| Project/Area Number |
22591649
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | National Rehabilitation Center for Persons with Disabilities |
|---|
Principal Investigator |
TOBIMATSU Yoshiko 国立障害者リハビリテーションセンター(研究所), 研究所 義肢装具技術研究部, 部長 (20172174)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGATA Toru 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 部長 (00392192)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | バイオマーカー / 軸索損傷 / ヒト脊髄損傷 / ELISA |
|---|
| Research Abstract |
To assess the efficacy of plasma pNF-H as a biomarker of axonal injury, we performed a pilot cross-sectional study of patients with acute cervical spinal cord injury (SCI). The pNF-H assay was carried out with a commercially available ELISA kit. Plasma pNF-H was elevated in accordance with the severity of SCI and reflected a greater magnitude of axonal damage. Therefore, pNF-H is a potential biomarker to independently distinguish AIS A patients (complete SCI) from AIS C-E patients (incomplete SCI).
|
Report
(4 results)
Research Products
(16 results)
