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The efficacy of blood biomarkers in acute or sub-acute spinal cord injury

Research Project

Project/Area Number 22591649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNational Rehabilitation Center for Persons with Disabilities

Principal Investigator

TOBIMATSU Yoshiko  国立障害者リハビリテーションセンター(研究所), 研究所 義肢装具技術研究部, 部長 (20172174)

Co-Investigator(Kenkyū-buntansha) OGATA Toru  国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 部長 (00392192)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsバイオマーカー / 軸索損傷 / ヒト脊髄損傷 / ELISA
Research Abstract

To assess the efficacy of plasma pNF-H as a biomarker of axonal injury, we performed a pilot cross-sectional study of patients with acute cervical spinal cord injury (SCI). The pNF-H assay was carried out with a commercially available ELISA kit. Plasma pNF-H was elevated in accordance with the severity of SCI and reflected a greater magnitude of axonal damage. Therefore, pNF-H is a potential biomarker to independently distinguish AIS A patients (complete SCI) from AIS C-E patients (incomplete SCI).

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (12 results)

  • [Journal Article] 血中バイオマーカーによる脊髄損傷の重症度評価の試み2012

    • Author(s)
      緒方徹
    • Journal Title

      リハビリテーション医学

      Volume: 49 Pages: 501-503

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated neurofila ment subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients, a pilot study.2012

    • Author(s)
      Hayakawa K., Ueno T., Ogata T., Tobimatsu Y., et al.
    • Journal Title

      Spinal Cord

      Volume: 50(7) Pages: 493-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated neurofilament subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients, a pilot study2012

    • Author(s)
      Hayakawa K, 他
    • Journal Title

      Spinal Cord

      Volume: 50 Issue: 7 Pages: 493

    • DOI

      10.1038/sc.2011.184

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオマーカーによるヒト脊髄損傷の予後予測の試み2011

    • Author(s)
      早川謙太郎,緒方徹
    • Journal Title

      Bone Joint Nerve

      Volume: 1(3) Pages: 495-500

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 血中神経損傷バイオマーカーpNF-Hの臨床利用と限界2012

    • Author(s)
      緒方徹、早川謙太郎ら
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 血中神経損傷バイオマーカーpNF-Hの臨床利用と限界2012

    • Author(s)
      緒方徹
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2012-10-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] pNF-H as a biomarker for evaluating severity of acute spinal cord injury patients2012

    • Author(s)
      Hayakawa K., Ogata T., et al.
    • Organizer
      Neuroscience2012
    • Place of Presentation
      ニューオリンズ(米国)
    • Year and Date
      2012-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] pNF-H as a biomarker for evaluating severity of acute spinal cord injury patients2012

    • Author(s)
      Hayakawa K., Ogata T., et al.
    • Organizer
      第8回ヨーロッパ神経科学フォーラム
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2012-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Phosphorylated Neurofilament subunit NF-H as a biomarker for evaluating severity of acute spinal cord injury.2012

    • Author(s)
      Hayakawa K, Okazaki R, Ishii K, Morioka K, Tanaka S, Ogata T.
    • Organizer
      第8回ヨーロッパ神経科学フォーラム
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2012-07-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evaluation of Severity of Spinal Cord Injury by Blood Biomarkers2012

    • Author(s)
      Ogata T., Hayakawa K., Tobimatsu Y, et al.
    • Organizer
      AOCPRM 2012
    • Place of Presentation
      バリ(インドネシア)
    • Year and Date
      2012-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄再生医療におけるバイオマーカーの役割2011

    • Author(s)
      緒方徹
    • Organizer
      第46回日本脊髄障害医学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血中バイオマーカーによる脊髄損傷の重症度評価の試み2011

    • Author(s)
      早川謙太郎、緒方徹
    • Organizer
      第46回日本脊髄障害医学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 血中バイオマーカーによる脊髄損傷の重症度評価の試み2011

    • Author(s)
      緒方徹、飛松好子、赤居正美
    • Organizer
      第48回日本リハビリテーション医学会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄再生治療における血液バイオマーカーの意義2011

    • Author(s)
      緒方徹、早川謙太郎ら
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-10-21
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] pNF-H as a biomarker for evaluating severity of acute spinal cord injury patients2011

    • Author(s)
      緒方徹、早川謙太郎、飛松好子ら
    • Organizer
      第34回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 血中バイオマーカーによるヒト脊髄損傷の重症度評価の試み2010

    • Author(s)
      石井桂輔、緒方徹ら
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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