Distinguishing the Proapoptotic and Antiresorptive Functions of Bisphosphonates inMurine Osteoclasts
| Project/Area Number |
22591679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Sakae 東京大学, 医学部附属病院, 教授 (50282661)
TAKETOMI Shuji 東京大学, 医学部附属病院, 助教 (70570018)
小倉 浩一 東京大学, 医学部附属病院, 助教 (20583115)
増出 和浩 (増田 和浩) 東京大学, 医学部附属病院, 助教 (70407948)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨 / 軟骨代謝学 / 骨・軟骨代謝学 / リセドロネート / 破骨細胞 / 細胞骨格 / Akt |
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| Research Abstract |
Nitrogen-containing bisphosphonates are one of the most successful therapeutics for osteoporosis. The aim of this study was to elucidate the functional mechanism of nitrogencontaining bisphosphonates. This study indicates that the antiresorptive effect of nitrogen-containing bisphosphonates is mainly mediated by the suppression of the bone-resorbing activity of osteoclasts and not by the induction of osteoclast apoptosis.
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Report
(4 results)
Research Products
(8 results)
