echanism of cartilage protection by hyaluronan
| Project/Area Number |
22591687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Keiichiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80284058)
HIROHATA Satoshi 岡山大学, 国際センター, 准教授 (90332791)
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| Co-Investigator(Renkei-kenkyūsha) |
NINOMIYA Yoshifumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70126241)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 関節軟骨 / ヒアルロン酸 / ADAMTS / アグリカン / メカノセンサー / 医療・福祉 / アグリカナーゼ / 変形性関節症 / 細胞外マトリックス / メカニカルストレス / 遺伝子 |
|---|
| Research Abstract |
Hyaluronan (HA) treatment suppressed cytokine induced cartilage proteolytic enzymes ADAMTS4 and 9 mRNA expression in OUMS-27 size dependently. In addition, intra-articular HA injection protected knee cartilage destruction and aggrecan degradation in a size dependent manner in rat OA model. Our results show HA might be used as drug for early stage osteoarthritis.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] The tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis2012
Author(s)
Obika M, Ogawa H, Takahashi K, Li J, Hatipoglu OF, Cilek MZ, Miyoshi T, Inagaki J, Ohtsuki T, Kusachi S, Ninomiya Y, Hirohata S
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Journal Title
Cancer Sci
Volume: 10巻、103号
Pages: 1889-97
NAID
Related Report
Peer Reviewed
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[Journal Article] AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo2011
Author(s)
Zeynel Cilek M, Hirohata S, Faruk Hatipoglu O, Ogawa H, Miyoshi T, Inagaki J, Ohtsuki T, Harada H, Kamikawa S, Kusachi S, Ninomiya Y
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Journal Title
Cell Biol Int
Volume: 35巻、1号
Pages: 1-8
Related Report
Peer Reviewed
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