| Project/Area Number |
22591687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
|
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Keiichiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80284058)
HIROHATA Satoshi 岡山大学, 国際センター, 准教授 (90332791)
|
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| Co-Investigator(Renkei-kenkyūsha) |
NINOMIYA Yoshifumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70126241)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
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| Keywords | 関節軟骨 / ヒアルロン酸 / ADAMTS / アグリカン / メカノセンサー / 医療・福祉 / アグリカナーゼ / 変形性関節症 / 細胞外マトリックス / メカニカルストレス / 遺伝子 |
|---|
| Research Abstract |
Hyaluronan (HA) treatment suppressed cytokine induced cartilage proteolytic enzymes ADAMTS4 and 9 mRNA expression in OUMS-27 size dependently. In addition, intra-articular HA injection protected knee cartilage destruction and aggrecan degradation in a size dependent manner in rat OA model. Our results show HA might be used as drug for early stage osteoarthritis.
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