Induction of chondrocyte from human induced pluripotent stem cells
| Project/Area Number |
22591693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kinki University |
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Principal Investigator |
FUKUDA Kanji 近畿大学, 医学部, 教授 (50201744)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIO Kazuto 近畿大学, 医学部, 教授 (10208134)
TERAMURA Takeshi 近畿大学, 医学部, 講師 (40460901)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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|---|
| Keywords | 軟骨 / iPs細胞 / 分化誘導 / 再生医療 / iPS細胞 |
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| Research Abstract |
Induction of chondrocyte from iPS cells is an important to treat osteoarticular disorders. We performed 1) induction of the chondrocyte from iPS cells via MSC production from iPS cells; 2) detailed characterization of the MSCs; 3) observation of cellular responses to mechanical stresses. These experiments elucidated that 1) hypoxic treatment during in vitro differentiation is a positive factor for induction of the MSCs, 2) induced MSCs possess typical MSC characteristics and 3) loading of the mechanical stress induce decreasing of the genes controlling undifferenciency of the cells. The present series of studies suggest an effective method to furnish the chondrocyte from iPS cells.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Generation of Embryonic Stem Cell Lines from Immature Rabbit Ovarian Follicles2013
Author(s)
Teramura T, Sugimoto H, Frampton J, Kida Y, Nakano M, Kawakami M, Izumi H, Fukunaga N, Onodera Y, Takehara T, Fukuda K, Hosoi Y
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Journal Title
Stem Cells Dev
Volume: 22(6)
Pages: 928-38
Related Report
Peer Reviewed
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[Journal Article] Induction of Functional Mesenchymal Stem Cells from Rabbit Embryonic Stem Cells by Exposure to Severe Hypoxic Conditions2013
Author(s)
Teramura T, Onodera Y, Takehara T, Frampton J, Matsuoka T, Ito S, Nakagawa K, Miki Y, Hosoi Y, Hamanishi C, Fukuda K
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Journal Title
Cell Transplant
Volume: 22(2)
Pages: 309-29
Related Report
Peer Reviewed
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